 Home > Encyclopedia > 2-Methoxybenzylamine

2-Methoxybenzylamine

2-Methoxybenzylamine structure

CAS No:
6850-57-3
Formula:
C8H11NO
Chemical Name:
2-Methoxybenzylamine
Synonyms:
Benzenemethanamine,2-methoxy-;Benzylamine,o-methoxy-;2-Methoxybenzenemethanamine;o-Methoxybenzylamine;2-Methoxybenzylamine;o-Methoxybenzenemethanamine;(o-Anisylmethyl)amine;2-Methoxyphenylmethylamine;(2-Methoxyphenyl)methanamine;1-[2-(Methyloxy)phenyl]methanamine;1-(2-Methoxyphenyl)methanamine;2-(Aminomethyl)anisole;844682-95-7
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

Request for Quotation

Description

Colorless to light yellow liqui

2-Methoxybenzylamine Basic Attributes

Molecular Weight：

137.18

Exact Mass：

137.18

BRN：

1100448

EC Number：

229-941-7

UNII：

2JK6T542T8

DSSTox ID：

DTXSID60218629

HScode：

29221980

Characteristics

PSA：

35.2

XLogP3：

1.85420

Appearance：

Clear colorless to slightly yellow Liquid

Density：

1.0±0.1 g/cm3

Melting Point：

60 °C

Boiling Point：

229 °C

Flash Point：

212 °F

Refractive Index：

1.533

Water Solubility：

H2O: slightly soluble

Storage Conditions：

Store below +30°C.

Safety Information

Packing level：

Ⅱ

Hazard category：

Transport codes：

UN 2735 8/PG 2

wgk germany：

hazard class code：

34-37

safety instructions：

26-36/37/39-45-27

Marks：

C,Xi

Hazard note：

Irritant

Stability/Shelf Life：

Stable under normal temperatures and pressures.

Precautionary statement(s)：

P280-P305 + P351 + P338-P310

Hazard Statements：

H314

GHS Classification：

|Danger|H314 (100%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]|P260, P264, P280, P301+P330+P331, P303+P361+P353, P304+P340, P305+P351+P338, P310, P321, P363, P405, and P501|Aggregated GHS information provided by 46 companies from 5 notifications to the ECHA C&L Inventory.

2-Methoxybenzylamine Use and Manufacturing

Methods of Manufacturing

To the mixture of 2-bromoanisole (0.020 ml, 0.16 mmol) and 1, 4-dioxane (2 ml), water (0.2 ml), cesium carbonate (0.32 g, 0.97 mmol), sodium 1, 3-dioxo-1, 3-dihydro-isoindole-2-ylmethyl trifluoroborate (81 mg, 0.32 mmol), palladium(II) acetate (3.6 mg, 0.016 mmol), and 2-dicyclohexylphosphino-2', 6'-dimethoxybiphenyl (13 mg, 0.032 mmol) were added, and then the obtained reaction mixture was stirred at 95° C. (an outer temperature) overnight. The reaction mixture was cooled to room temperature, and then hydrazine hydrate (0.039 ml, 0.81 mmol) and methanol (2 ml) were added thereto, followed by heating to reflux for 1 hour. The reaction mixture was cooled to room temperature, and then water and ethyl acetate were added to the reaction mixture, followed by filtration with celite. The organic layer of the filtrate was separated and washed with saline. The solvents were evaporated under reduced pressure from the organic layer, and then the obtained residue was purified with NH-silica gel column chromatography (heptane:ethyl acetate=1:4), thereby obtaining the entitled compound (4.1 mg, 19percent) as the mixture with 2'-(dicyclohexyl-phosphinoyl)-2, 6-dimethoxy-biphenyl (6.2 mg).

Uses

2-Methoxybenzylamine is a 2-methoxy derivative of benzylamine. 2-Methoxybenzylamine is one the the metabolites detected in urine after metabolism of dopamine analogues. 2-Methoxybenzylamine is used in the preparation of GABAA receptor ligands as analgesic agents.

Computed Properties

Molecular Weight:137.18
XLogP3:0.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:137.084063974
Monoisotopic Mass:137.084063974
Topological Polar Surface Area:35.2
Heavy Atom Count:10
Complexity:95.3
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Recommended Suppliers of 2-Methoxybenzylamine

HANGZHOU LEAP CHEM CO., LTD. Contact Supplier

CN
5 YRS

Business licensed

Trader Supplier of Intermediates,Building blocks,API,Silicones,Peptides,Lab chemicals,Biochemicals,Pharmaceuticals,Screening Compounds,Food Additives

2-Methoxybenzylamine

CAS No.: 6850-57-3

Content: 99.00%

Inquiry
NANTONG REFORM PETRO-CHEMICAL CO.,LTD Contact Supplier

CN
4 YRS

Business licensed Certified factory

Manufactory Supplier of Flavors & Fragrances,Catalyst & Auxiliary,Intermediates,Dyes & Pigments,Inorganic Chemistry,petro chemicals,Surfactant,Food Additives,Water Treatment Chemicals

2-Methoxybenzylamine

CAS No.: 6850-57-3

Grade: Industrial Grade

Content: 99%

Inquiry