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Ponazuril

Ponazuril structure

CAS No:
69004-04-2
Formula:
C18H14F3N3O6S
Chemical Name:
Ponazuril
Synonyms:
Toltrazuril sulfone Ponazuril;1-Methyl-3-{3-methyl-4-[4-(trifluoromethylsulfonyl)phenoxy]phenyl}-1,3,5-triazine-2,4,6(1H,3H;Ponazuril;ToltrazurilSulfone;1-Methyl-3-{3-methyl-4-[4-(trifluoromethylsulfonyl)phenoxy]phenyl}-1,3,5-triazine-2,4,6(1H,3H,5H)-trione;Ponazuril [inn];Unii-jpw84as66u;1-methyl-3-[3-methyl-4-[4-(trifluoromethylsulfonyl)phenoxy]phenyl]-1,3,5-triazinane-2,4,6-trione
Categories:
Chemical Reagents > Organic Reagents

Description

Ponazuril, sold by the Bayer Corporation under the trade name Marquis, is a drug currently approved for the treatment of equine protozoal myeloencephalitis in horses, caused by Sarcocystis neurona.

Toltrazuril sulfone is an active metabolite of the coccidiostat toltrazuril . Toltrazuril sulfone is formed from toltrazurilviathe intermediate metabolite toltrazuril sulfoxide by cytochrome P450 (CYP) enzymes, including CYP3A. It inhibitsT. gondiitachyzoite production in African green monkey kidney cells when used at concentrations of 0.1, 1, and 5 μg/ml. Toltrazuril sulfone completely prevents infection withT. gondiitachyzoites in a mouse model of fatal toxoplasmosis when administered at doses of 10 or 20 mg/kg one day prior to, and daily for 10 days following, infection. It also reduces the number of infected mice in the same model when administered at a dose of 10 mg/kg for 11 days starting six days following infection. Formulations containing toltrazuril sulfone have been used in the treatment of equine protozoal myeloencephalitis (EPM) in horses.

Ponazuril Basic Attributes

Molecular Weight：

457.38

Exact Mass：

457.38

EC Number：

629-740-8

UNII：

JPW84AS66U

DSSTox ID：

DTXSID7048958

Color/Form：

White to Off-White

Characteristics

PSA：

122

XLogP3：

3.1

Density：

1.507±0.06 g/cm3(Predicted)

Melting Point：

242°

Refractive Index：

1.572

PKA：

6.46±0.20(Predicted)

Critical Temperature & Pressure：

Refrigerator

Safety Information

wgk germany：

Precautionary statement(s)：

P273, P391, P501

Hazard Statements：

H411

Drug Information

MeSH Entry Terms：

ponazuril

Ponazuril Use and Manufacturing

Uses

Toltrazuril sulfone is antiprotazoal, used to treat Equine Protozoal Myeloencephalitis (EPM).

Use Classification：

Animal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients

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