 Home > Encyclopedia > Bz-rA Phosphoramidite

Bz-rA Phosphoramidite

Bz-rA Phosphoramidite structure

CAS No:
104992-55-4
Formula:
C53H66N7O8PSi
Chemical Name:
Bz-rA Phosphoramidite
Synonyms:
Bz-rA Phosphoramidite;DMT-2"O-TBDMS-Ra(Bz) Phosphoramidite;(2R,3R,4R,5R)-5-(6-Benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite;DMT-2"O-TBDMS-rA(bz) amidite;N-[9-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3-[tert-butyl(dimethyl)silyl]oxy-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxyoxolan-2-yl]purin-6-yl]benzamide;DMT-2"O-TBDMS-rA(bz) Pharmadite(R);DMT-2"O-TBDMS-rA(bz) Phosphoramidite, configured for ABI;DMT-2"O-TBDMS-rA(bz) Phosphoramidite, configured for MerMade;N-Benzoyl-5"-O-(4,4-Dimethoxytrityl)-2"-O-[(tert-butyl)dimethylsilyl]adenosine-3"-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite;C53H66N7O8PSi
Categories:
Biochemical Engineering > Nucleoside Drugs

Request for Quotation

Bz-rA Phosphoramidite Basic Attributes

Molecular Weight：

988.19

Exact Mass：

987.447998

DSSTox ID：

DTXSID40463231

Characteristics

PSA：

164

XLogP3：

11.12650

Safety Information

Transport codes：

NONH for all modes of transport

Bz-rA Phosphoramidite Use and Manufacturing

To a solution of 72 (12.0 g, 15.2 mmoi) in DIPEA (15 ml) and DCM (30 niL’) is added DMAP (744 mg, 6.09 rnrnol) and 2cyanoethyl JV.Ndiisopropylchlorophosphoramidite (5.41 g, 22.9 rnmoi) at 25 °C. After stirring for 2 hours, the mixture is purified directly by basic silica gel column chromatography (EAIPE 1/4 toi/1) to give A2 as a white solid (13.0 g. 86percent yield)Examples 12-18; These Examples illustrate the phosphitylation of several protected nucleoside reagents with 2-Cyanoethyl-N, N, N', N'-tetraisopropylphosphordiamidite in the presence of a Huenig's Base-TFA activator according to the present invention. Seven nucleoside reagents of the Formula III (below) were reacted with 2-Cyanoethyl-N, N, N', N'-tetraisopropylphosphordiamidite in the presence of a Huenig's Base-TFA activator according to the General Procedure for Examples 1-11, and the product yield calculated via one of two methods: (1) the resulting product mixture is run through an HPLC column using an appropriate eluent, and the area under the HPLC peaks used to determine the percentyield of product in the mixture; or (2) the resulting product is purified on a short silica gel column using a methylacetate/toluene mixture (the concentration depending on the particular product being purified). The appropriate product fractions are concentrated under reduced pressure and solvent until an approximately 50percent solution of the desired amidite is obtained. This solution is added to about 5 to 25 equivalents of petroleum ether to precipitate the product which is filtered and washed with petroleum ether. The product is then dried, weighed, and the percent yield calculated.

Computed Properties

Molecular Weight:988.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:13
Rotatable Bond Count:22
Exact Mass:987.44797562
Monoisotopic Mass:987.44797562
Topological Polar Surface Area:164
Heavy Atom Count:70
Complexity:1630
Defined Atom Stereocenter Count:4
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Recommended Suppliers of Bz-rA Phosphoramidite

Nanjing Paron Technology Co., Ltd Contact Supplier

CN
6 YRS

Business licensed Certified factory

Manufactory Supplier of chemicals

DM-T-2'-O-TBDMS-A(Bz)-CE-Phosphoramidite high quality

CAS No.: 104992-55-4

Grade: Pharmaceutical Grade

Content: 99%

Inquiry
HANGZHOU LEAP CHEM CO., LTD. Contact Supplier

CN
5 YRS

Business licensed

Trader Supplier of Intermediates,Building blocks,API,Silicones,Peptides,Lab chemicals,Biochemicals,Pharmaceuticals,Screening Compounds,Food Additives

N-Benzoyl-5-O-(4,4-Dimethoxytrityl)-2-O-[(tert-butyl)dimethylsilyl]adenosine-3-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite

CAS No.: 104992-55-4

Content: 99.00%

Inquiry
Wuhu Nuowei Chemistry Technologies Co., Ltd. Contact Supplier

CN
7 YRS

Business licensed Certified factory

Manufactory Supplier of Carbohydrates,Nucleosides & Nucleotides,Ionic liquids

Bz-rA Phosphoramidite First Grade

CAS No.: 104992-55-4

Grade: Guaranteed Reagent

Inquiry

Learn More Other Chemicals

ibu-rG Phosphoramidite

147201-04-5
BIOTIN PHOSPHORAMIDITE FOR ABI

196408-65-8
Ac-rC Phosphoramidite

121058-88-6
N4-(DIMETHYLAMINO)METHYLENE)-5'-O-(DIMETHOXYTRITYL)-2'-DEOXYGUANOSINE-3'-N,N-DIISOPROPYL (CYANOETHYL) PHOSPHORAMIDITE Formula

330628-04-1
3'-TBDMS-ibu-rG Phosphoramidite Formula

1445905-51-0
BIS(2-CYANOETHYL)-N,N-DIISOPROPYL PHOSPHORAMIDITE Formula

102690-88-0
CIS,SYN-THYMIDINE DIMER METHYL PHOSPHORAMIDITE Structure

118187-67-0
6-FAM phosphoramidite [5'-Fluorescein ... Structure

204697-37-0
What is 3'-TBDMS-Bz-rA Phosphoramidite

129451-75-8
What is DNA ligase (ATP)

9015-85-4

Hot Searches: vanadium nitride; sucrose acetate isobutyrate; albendazole; potassium sulphate formula; toluene formula; n2o3 name

Guide of Bz-rA Phosphoramidite

Basic Attributes
Characteristics
Safety Information
Use and Manufacturing
Computed Properties
Recommended Suppliers
Learn More Other Chemicals

Bz-rA Phosphoramidite

SDS

Request for Quotation



Feedback & Suggestions

Send Message

Thank you for your feedback. If you require further assistance, please contact us by email at info@echemi.com or call us at +86-532-55729510.