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Medetomidine

Medetomidine structure

CAS No:
86347-14-0
Formula:
C13H16N2
Chemical Name:
Medetomidine
Synonyms:
1H-Imidazole,5-[1-(2,3-dimethylphenyl)ethyl]-;1H-Imidazole,4-[1-(2,3-dimethylphenyl)ethyl]-;5-[1-(2,3-Dimethylphenyl)ethyl]-1H-imidazole;Medetomidine;dl-Medetomidine;(±)-Medetomidine;Slectope;Selektope;106807-72-1;2227379-35-1
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

Description

Medetomidine(Domtor) is a potent, highly selective α2-adrenoceptor agonist (Ki values are 1.08 and 1750 nM for α2- and α1-adrenoceptors respectively). IC50 value:Target: α2-adrenoceptorMedetomidine displays greater selectivity over α1-adrenoceptors than clonidine and UK 14,304 (1620-, 220- and 300-fold respectively). Medetomidine inhibits twitch response in electrically stimulated mouse vas deferens (pD2 = 9.0). Active in vivo; displays hypotensive, bradycardic, sedative, anxiolytic, hyp

Medetomidine is a member of imidazoles.|Medetomidine is a synthetic compound used as a surgical anesthetic and analgesic. It is normally found as its hydrochloride salt, medetomidine hydrochloride. Medetomidine is an intravenously available alpha-2 adrenergic agonist. The drug has been developed by Orion Pharma. In the United States, it is currently approved for its veterinary use in dogs and distributed by Pfizer Animal Health. In Canada, medetomidine is distributed by Novartis Animal Health. The marketed product is a racemic mixture of two stereoisomers from which dexmedetomidine is the main active isomer.|An agonist of RECEPTORS, ADRENERGIC ALPHA-2 that is used in veterinary medicine for its analgesic and sedative properties. It is the racemate of DEXMEDETOMIDINE.

Medetomidine Basic Attributes

Molecular Weight：

200.28

Exact Mass：

200.28

DSSTox ID：

DTXSID6048258

HScode：

2933290090

Characteristics

PSA：

28.7

XLogP3：

3.1

Density：

1.1±0.1 g/cm3

Melting Point：

151.5 - 152.5ºC

Boiling Point：

381.9°C at 760 mmHg

Flash Point：

191.3±5.7 °C

Refractive Index：

1.570

Safety Information

GHS Classification：

|Danger|H300: Fatal if swallowed [Danger Acute toxicity, oral]|P260, P261, P264, P270, P271, P273, P284, P301+P310, P304+P340, P307+P311, P310, P312, P314, P320, P321, P330, P391, P403+P233, P405, and P501|H300 (100%): Fatal if swallowed [Danger Acute toxicity, oral]|P260, P264, P270, P271, P273, P284, P301+P310, P304+P340, P310, P320, P321, P330, P391, P403+P233, P405, and P501|Aggregated GHS information provided by 23 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH：

A subclass of analgesic agents that typically do not bind to OPIOID RECEPTORS and are not addictive. Many non-narcotic analgesics are offered as NONPRESCRIPTION DRUGS. (See all compounds classified as Analgesics, Non-Narcotic.)|Compounds that bind to and activate ADRENERGIC ALPHA-2 RECEPTORS. (See all compounds classified as Adrenergic alpha-2 Receptor Agonists.)|Drugs used to induce drowsiness or sleep or to reduce psychological excitement or anxiety. (See all compounds classified as Hypnotics and Sedatives.)

MeSH Entry Terms：

Hydrochloride, Medetomidine

Medetomidine Use and Manufacturing

Uses

Analgesic (veterinary); sedative (veterinary).

Use Classification：

Animal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients

Computed Properties

Molecular Weight:200.28
XLogP3:3.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:2
Exact Mass:200.131348519
Monoisotopic Mass:200.131348519
Topological Polar Surface Area:28.7
Heavy Atom Count:15
Complexity:205
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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