4-(3-Piperidinyl)benzenamine

(20.0 g), methanol (180 mL) and 0.1 m hydrochloric acid are added to a hydrogenation reaction, and the reaction is carried out in the same manner as in the literature (Org. Process Res. Dev.2011, 15, 831-840). Specifically, 3- (4-nitrophenyl) Kettle, then add PtOCompound 3 (36.0 g, 0.19 mol) was dissolved in 190 mL of methylene chloride under a nitrogen atmosphere, Diisopropylethylamine (27.0 g, 0.21 mol) was added and the temperature was lowered to -60 ° C. Trifluoromethanesulfonic anhydride (59.2 g, 0.21 mol) was added and reacted at this temperature. After the reaction, water was added, the temperature was raised to room temperature, the mixture was extracted with ethyl acetate, and saturated sodium bicarbonateAfter washing and drying of the organic phase, the solvent was distilled off under reduced pressure to give 44.5 g of compound 3 as a light yellow solid.

Molecular Weight:176.26
XLogP3:1.4
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:176.131348519
Monoisotopic Mass:176.131348519
Topological Polar Surface Area:38
Heavy Atom Count:13
Complexity:150
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes