1-(cyclopropylcarbonyl)-, Monohydrochloride
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1-(cyclopropylcarbonyl)-, Monohydrochloride
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CAS No:
1021298-67-8
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Formula:
C8H15ClN2O
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Chemical Name:
1-(cyclopropylcarbonyl)-, Monohydrochloride
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Synonyms:
1-(cyclopropylcarbonyl)piperazine hydrochloride;Piperazine, 1-(cyclopropylcarbonyl)-, Monohydrochloride;cyclopropyl(piperazin-1-yl)methanone hydrochloride;1-cyclopropanecarbonylpiperazine hydrochloride;CYCLOPROPYL(PIPERAZIN-1-YL)METHANONE HCL;MFCD03428576;1-(Cyclopropylcarbonyl)piperazine HCl;cyclopropylcarboxylic acid-1-piperazineamide hydrochloride;Methanone, cyclopropyl-1-piperazinyl-, hydrochloride (1:1);cyclopropyl piperazinyl ketone, chloride
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CAS No:
Safety Information
|Warning|H228 (96.97%): Flammable solid [Danger Flammable solids]|P210, P240, P241, P261, P264, P270, P272, P280, P301+P312, P302+P352, P305+P351+P338, P321, P330, P332+P313, P333+P313, P337+P313, P362, P363, P370+P378, and P501|Aggregated GHS information provided by 66 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
1-(cyclopropylcarbonyl)-, Monohydrochloride Use and Manufacturing
To a stirred mixture of compound tert-butyl 4-(cyclopropanecarbonyl)piperazine-1-carboxylate (3.7 g, 14.5 mmol) in methanol (15 mL) was added hydrochloride/methanol (15 mL, 3M)) at 0° C. After the addition, the mixture was allowed to stir at room temperature overnight. The mixture was concentrated to give cyclopropyl(piperazin-1-yl)methanone hydrochloride (2.74 g, yield 100percent) as an off-white solid. Example 17BCyclopropyl(piperazin- 1 -yl)methanone hydrochloride[00524] To a stirred mixture of compound ter/-butyl 4-(cyclopropanecarbonyl)piperazine- 1 -carboxylate (3.7 g, 14.5 mmol) in methanol (15 mL) was added hydrochloride/methanol (15 mL, 3M)) at 0 °C. After the addition, the mixture was allowed to stir at room temperature overnight. The mixture was concentrated to give cyclopropyl(piperazin- 1 -yl)methanone hydrochloride (2.74 g, yield 100percent) as an off- white solid. ^-NMR (400 MHz, DMSO-i/6) δ (ppm): 0.71-0.76 (m, 4H), 1.96-2.03 (m, 1H), 3.04-3.16 (m, 4H), 3.69-4.08 (m, 4H), 9.58 (s, 2H); LC-MS (ESI) m/z: 155(M+1)
Computed Properties
Molecular Weight:190.67
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:190.0872908
Monoisotopic Mass:190.0872908
Topological Polar Surface Area:32.3
Heavy Atom Count:12
Complexity:160
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes
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1-(cyclopropylcarbonyl)-, Monohydrochloride
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