GDC-0810
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GDC-0810
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CAS No:
1365888-06-7
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Formula:
C26H20ClFN2O2
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Chemical Name:
GDC-0810
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Synonyms:
GDC-0810(ARN-810);GDC-0810;ARN-810;Brilanestrant);(E)-3-[4-[(E)-2-(2-Chloro-4-fluorophenyl)-1-(1H-indazol-5-yl)but-1-en-1-yl]phenyl]-2-propenoic acid;GDC-0810 (Brilanestrant)
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CAS No:
Description
ARN-810 has been used in trials studying the basic science and treatment of Breast Cancer.|Brilanestrant is an orally available, nonsteroidal selective estrogen receptor degrader (SERD), with potential antineoplastic activity. Upon oral administration, brilanestrant binds to the estrogen receptor and induces a conformational change that results in the degradation of the receptor. This may inhibit the growth and survival of ER-expressing cancer cells.
Drug Information
3-(4-(2-(2-chloro-4-fluorophenyl)-1-(1H-indazol-5-yl)but-1-en-1-yl)phenyl)acrylic acid
Computed Properties
Molecular Weight:446.9
XLogP3:7.4
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:6
Exact Mass:446.1197337
Monoisotopic Mass:446.1197337
Topological Polar Surface Area:66
Heavy Atom Count:32
Complexity:719
Defined Bond Stereocenter Count:2
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes