Genz-123346
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Genz-123346
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CAS No:
491833-30-8
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Formula:
C24H38N2O4
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Chemical Name:
Genz-123346
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Synonyms:
(2-(2",3"-dihydrobenzo(1,4)dioxin-6"-yl)-2-hydroxy-1-pyrrolidin-1-ylmethylethyl)nonanoic acid amide;Genz 123346;Genz-123346;Genz123346;Genz-123346 free base;Genz-123346 (free base);N-[(1R,2R)-1-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl]nonanamide;N-((1R,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)nonanamide;Genz-123346(freebase)
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CAS No:
Description
Genz-123346 (free base) is an inhibitor of GL1 synthase that blocks the conversion of ceramide to GL1; inhibits GM1 with IC50 value of 14 nM.
Drug Information
(2-(2',3'-dihydrobenzo(1,4)dioxin-6'-yl)-2-hydroxy-1-pyrrolidin-1-ylmethylethyl)nonanoic acid amide
Computed Properties
Molecular Weight:418.6
XLogP3:4.2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:12
Exact Mass:418.28315770
Monoisotopic Mass:418.28315770
Topological Polar Surface Area:71
Heavy Atom Count:30
Complexity:498
Defined Atom Stereocenter Count:2
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
