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2-[[4-[1-Methyl-4-(4-pyridinyl)-1H-pyrazol-3-yl]phenoxy]methyl]quinoline

2-[[4-[1-Methyl-4-(4-pyridinyl)-1H-pyrazol-3-yl]phenoxy]methyl]quinoline structure

CAS No:
898562-94-2
Formula:
C25H20N4O
Chemical Name:
2-[[4-[1-Methyl-4-(4-pyridinyl)-1H-pyrazol-3-yl]phenoxy]methyl]quinoline
Synonyms:
Quinoline,2-[[4-[1-methyl-4-(4-pyridinyl)-1H-pyrazol-3-yl]phenoxy]methyl]-;2-[[4-[1-Methyl-4-(4-pyridinyl)-1H-pyrazol-3-yl]phenoxy]methyl]quinoline;2-[(4-(1-Methyl-4-(pyridin-4-yl)-1H-pyrazol-3-yl)phenoxy)methyl]quinoline;MP 10;PF 2545920;Mardepodect;PF 02545920
Categories:
Pharmaceutical Intermediates > CNS Agents

Description

PF-2545920 is a potent and selective PDE10A inhibitor with IC50 of 0.37 nM, with >1000-fold selectivity over the PDE. IC50 value: 0.37 nM [1]Target: PDE10APDE10A subcutaneously administrated at dose of 1 mg/kg elevates striatal cGMP about 3 fold in male CD-1 mice, while PDE10A subcutaneously administrated at dose of 3.2 mg/kg displays a maximal elevation of striatal cGMP approximately a 5-fold increase in male CD-1 mice. PDE10A intravenous injected at a dose of 0.1 mg/kg in Sprague-Dawle

2-[[4-[1-Methyl-4-(4-pyridinyl)-1H-pyrazol-3-yl]phenoxy]methyl]quinoline Basic Attributes

Molecular Weight：

392.453

Exact Mass：

392.45

UNII：

R9Y8EY0G42

HScode：

2933990090

Characteristics

PSA：

52.83000

XLogP3：

3.52

Density：

1.2±0.1 g/cm3

Boiling Point：

568.6±50.0 °C at 760 mmHg

Flash Point：

297.7±30.1 °C

Refractive Index：

1.661

Drug Information

MeSH Entry Terms：

((11)C)MP-10

Computed Properties

Molecular Weight:392.5
XLogP3:4.2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:5
Exact Mass:392.16371127
Monoisotopic Mass:392.16371127
Topological Polar Surface Area:52.8
Heavy Atom Count:30
Complexity:531
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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Quinoline, 2-[[4-[1-methyl-4-(4-pyridinyl)-1H-pyrazol-3-yl]phenoxy]methyl]-

CAS No.: 898562-94-2

Content: 99.00%

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Guide of 2-[[4-[1-Methyl-4-(4-pyridinyl)-1H-pyrazol-3-yl]phenoxy]methyl]quinoline

Description
Basic Attributes
Characteristics
Drug Information
Computed Properties
Recommended Suppliers
Latest News
Learn More Other Chemicals

2-[[4-[1-Methyl-4-(4-pyridinyl)-1H-pyrazol-3-yl]phenoxy]methyl]quinoline

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