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Romifidine hydrochloride

Romifidine hydrochloride structure

CAS No:
65896-14-2
Formula:
C9H10BrClFN3
Chemical Name:
Romifidine hydrochloride
Synonyms:
1H-Imidazol-2-amine, N-(2-bromo-6-fluorophenyl)-4,5-dihydro-, monohydrochloride;Romifidine Hydrochloride;N-(2-BroMo-6-fluorophenyl)-4,5-dihydro-1H-iMidazol-2-aMine Hydrochloride;Sedivet;STH 2130Cl;Romifidine Hydrochloride, Monohydrochloride;Romifidine HCl;1H-Imidazol-2-amine, N-(2-bromo-6-fluorophenyl)-4,5-dihydro-, hydrochloride (1:1)
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

Description

Romifidine hydrochloride [N-(2-b romifidineo-6-fluoro-phenyl)- 4,5-dihydro-1H-imidazol-2-amine mono-hydrochloride, C9H9BrFN3, MW 258.1; romifidine] is an imidazole derivative with potent a2-adrenoceptor agonist properties. It is commonly used in equine practice to provide sedation, analgesia, and muscle relaxation. A comparative study reported that an intravenous (i.v.) dose of 80 μg/kg romifidine is equipotent to 1 mg/kg xylazine i.v. and 20 μg/kg detomidine i.v.[1]. Typical signs of sedation include muscle relaxation, decreased head height (HH), diminished responsiveness to external stimuli, and postural abnormalities following romifidine administration. Furthermore, romifidine possesses antinociceptive activity. As an analgesic, it reduces anesthetic requirements for isoflurane in horses.

Romifidine hydrochloride Basic Attributes

Molecular Weight：

Exact Mass：

292.97307

EC Number：

202-303-5

UNII：

98LQ6RS0TA

DSSTox ID：

DTXSID80216102

Color/Form：

White

Characteristics

Critical Temperature & Pressure：

Inert atmosphere,Room Temperature

Safety Information

GHS Classification：

|Danger|H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]|P260, P264, P270, P301+P310, P307+P311, P321, P330, P405, and P501|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.

Romifidine hydrochloride Use and Manufacturing

Uses

An α2 agonist use as a sedative and analgesic.

As an α2 agonist used as a sedative and analgesic, RoMifidine Hydrochloride is a drug that is used in veterinary medicine as a sedative mainly in large animals such as horses.

Use Classification：

Animal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients

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