1-Methoxy-2-propyl acetate

132.15800

132.16

203-603-9

0800

2207

3271|1993

DTXSID1026796

Colorless liquid at 15 °C and 1 atm

2918199090

35.53000

0.5844

Appearance ：Colorless transparent liquid content：≥99.0%Moisture：≤0.05％distillation：145-152℃acidity：≤0.03％specific gravity（d420）：0.966 flash point：51°C

0.96 g/cm³

-87 °C

146 °C

110 °F

n20/D 1.402

H2O: 19.8 g/L (25 ºC)

Flammables area

Vapour pressure, kPa at 20°C: 0.5

Relative vapour density (air = 1): 4.6

vol% in air: 1.5.0 (at 200°C)

Sweet, ether-like

Henry's Law constant = 3.44X10-6 atm-cu m/mol at 25 °C (est)

Density: 0.962-0.967 g/cu cm at 20-25 °C. VP: 3.6-5.17 hPa at 20 25 °C. logP: 1.2 at 20 eg C, pH 6.8|Specific gravity: 0.966 at 25 °C/25 °C. Dipole moment: 1.8 debye|Hydroxyl radical reaction rate constant = 1.19X10-11 cu-cm/molc sec at 25 °C (est)

No rapid reaction with air No rapid reaction with water

Esters, Sulfate Esters, Phosphate Esters, Thiophosphate Esters, and Borate Esters

PROPYLENE GLYCOL METHYL ETHER ACETATE is an ester. Esters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides. Incompatible with oxidizers.

670 °F (USCG, 1999)|670 °F (354 °C)

(At 392 °F, or 200 °C): Lower- 1.5% by volume, Upper- 7.0% by volume.

III

3

UN 3271 3/PG 3

3

R61; R10; R36

S53; S25; S45

AI8925000

T; Xi

Fireproof. Separated from strong oxidants. Dry.

Stable. Flammable. Incompatible with strong oxidizing agents, acids, bases.

P210-P403 + P235

H226

SRP: Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in air, soil or water; effects on animal, aquatic and plant life; and conformance with environmental and public health regulations. If it is possible or reasonable use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination.|Product: Offer surplus and non-recyclable solutions to a licensed disposal company. Burn in a chemical incinerator equipped with an afterburner and scrubber but exert extra care in igniting as this material is highly flammable; Contaminated packaging: Dispose of as unused product.

Incompatible materials: Strong oxidizing agents.|Reacts with strong oxidants.

Special Hazards of Combustion Products: Carbon dioxide and carbon monoxide may form when heated to decomposition. (USCG, 1999)|Flammable. Above 42 °C explosive vapour/air mixtures may be formed.

|Warning|H226: Flammable liquid and vapor [Warning Flammable liquids]|P210, P233, P240, P241, P242, P243, P280, P303+P361+P353, P370+P378, P403+P235, and P501|H226 (100%): Flammable liquid and vapor [Warning Flammable liquids]|P210, P233, P240, P241, P242, P243, P261, P271, P280, P303+P361+P353, P304+P340, P312, P370+P378, P403+P233, P403+P235, P405, and P501|Aggregated GHS information provided by 3207 companies from 31 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|Danger|P201, P202, P210, P233, P240, P241, P242, P243, P280, P281, P303+P361+P353, P308+P313, P370+P378, P403+P235, P405, and P501|H320: Causes eye irritation [Warning Serious eye damage/eye irritation]|P261, P264, P271, P304+P340, P305+P351+P338, P312, P337+P313, P403+P233, P405, and P501|P210, P233, P240, P241, P242, P243, P261, P264, P271, P280, P303+P361+P353, P304+P340, P305+P351+P338, P312, P337+P313, P370+P378, P403+P233, P403+P235, P405, and P501

Excerpt from ERG Guide 127 [Flammable Liquids (Water-Miscible)]: As an immediate precautionary measure, isolate spill or leak area for at least 50 meters (150 feet) in all directions. LARGE SPILL: Consider initial downwind evacuation for at least 300 meters (1000 feet). FIRE: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2016)

Excerpt from ERG Guide 127 [Flammable Liquids (Water-Miscible)]: ELIMINATE all ignition sources (no smoking, flares, sparks or flames in immediate area). All equipment used when handling the product must be grounded. Do not touch or walk through spilled material. Stop leak if you can do it without risk. Prevent entry into waterways, sewers, basements or confined areas. A vapor-suppressing foam may be used to reduce vapors. Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers. Use clean, non-sparking tools to collect absorbed material. LARGE SPILL: Dike far ahead of liquid spill for later disposal. Water spray may reduce vapor, but may not prevent ignition in closed spaces. (ERG, 2016)

Safety goggles, protective clothing. Use approved respirator when possibility exists of encountering vapor. (USCG, 1999)|Eye/face protection: Face shield and safety glasses. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).|Skin protection: Handle with gloves.|Body Protection: Impervious clothing. Flame retardant antistatic protective clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.|Respiratory protection: Where risk assessment shows air-purifying respirators are appropriate use a full-face respirator with multipurpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).|Protective gloves. Protective clothing. Wear safety spectacles, face shield or eye protection in combination with breathing protection.

Flammable.

Above 42 °C explosive vapor/air mixtures may be formed.|Explosive limits , vol% in air: 1.5-7.0 (at 200 °C)

Suitable extinguishing media: Dry powder, dry sand. Unsuitable extinguishing media: Do NOT use water jet.|Advice for firefighters: Wear self-contained breathing apparatus for firefighting if necessary.|Use water spray to cool unopened containers.|Use alcohol-resistant foam, foam, powder, carbon dioxide. In case of fire: keep drums, etc., cool by spraying with water.|If material on fire or involved in fire: Use water in flooding quantities as fog. Use "alcohol" foam, dry chemical or carbon dioxide. Keep run-off water out of sewers and water sources. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible.

ACCIDENTAL RELEASE MEASURES: Personal precautions, protective equipment and emergency procedures: Use personal protective equipment. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Remove all sources of ignition. Evacuate personnel to safe areas. Beware of vapors accumulating to form explosive concentrations. Vapors can accumulate in low areas. Environmental precautions: Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Methods and materials for containment and cleaning up: Contain spillage, and then collect with non-combustible absorbent material, (e.g. sand, earth, diatomaceous earth, vermiculite) and place in container for disposal according to local/national regulations.|Collect leaking and spilled liquid in sealable containers as far as possible. Wash away remainder with plenty of water.

ACCIDENTAL RELEASE MEASURES: Personal precautions, protective equipment and emergency procedures: Use personal protective equipment. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Remove all sources of ignition. Evacuate personnel to safe areas. Beware of vapors accumulating to form explosive concentrations. Vapors can accumulate in low areas. Environmental precautions: Prevent further leakage or spillage if safe to do so. Do not let product enter drains.|Precautions for safe handling: Avoid inhalation of vapor or mist. Keep away from sources of ignition - No smoking. Take measures to prevent the build up of electrostatic charge.|Appropriate engineering controls: Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.|Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands.|For more Preventive Measures (Complete) data for 1-Methoxy-2-propyl acetate (10 total), please visit the HSDB record page.

The substance is irritating to the eyes and respiratory tract.

Collect leaking and spilled liquid in sealable containers as far as possible. Wash away remainder with plenty of water.

Fireproof. Separated from strong oxidants. Dry.

A harmful contamination of the air will be reached rather slowly on evaporation of this substance at 20 °C.

The substance is irritating to the eyes and respiratory tract. Exposure at high levels could cause depression of the central nervous system.

The substance defats the skin, which may cause dryness or cracking.

NO open flames, NO sparks and NO smoking. Above 42 °C use a closed system, ventilation and explosion-proof electrical equipment.

Use ventilation, local exhaust or breathing protection.

Protective gloves. Protective clothing.

Wear safety spectacles, face shield or eye protection in combination with breathing protection.

| 1 - Materials that, under emergency conditions, can cause significant irritation.| 2 - Materials that must be moderately heated or exposed to relatively high ambient temperatures before ignition can occur. Materials would not under normal conditions form hazardous atmospheres with air, but under high ambient temperatures or under moderate heating could release vapor in sufficient quantities to produce hazardous atmospheres with air.| 0 - Materials that in themselves are normally stable, even under fire conditions.

SOURCE DOMINATED: 1-Methoxy-2-propyl acetate was present as 10 and 27% of total emissions from two of nine large-scale semiconductor manufacturing facilities in Hsin-chu, Taiwan, monitoried from October 2000-September 2001. The total VOC emission factor was estimated to be 0.038 kg/L for semiconductor manufacturing processes(1).

1-Methoxy-2-propyl acetate was detected, not quantified, in coating emissions from 14 of 44 furniture samples in a 20-day chamber test. The average glycol emission concentration was 30.2 ug/cu m (range <1-1153 ug/cu m)(1).

IDENTIFICATION AND USE: 1-Methoxy-2-propyl acetate is used as a solvent in cosmetic formulations, as well as in surface coatings, inks, and cleaners. HUMAN STUDIES: The substance defats the skin, which may cause dryness or cracking. It is irritating to the eyes and respiratory tract. Exposure at high levels could cause depression of the central nervous system. ANIMAL STUDIES: Watery eyes, anorexia, rapid shallow breathing, and excess salivation were observed in rats given a single dose of 4000, 6300, or 10,000 mg/kg 1-methoxy-2-propyl acetate. 1-Methoxy-2-propyl acetate was not a skin irritant in rabbits. 10% 1-methoxy-2-propyl acetate in water was not a sensitizer in a guinea pig maximization test. Some slight changes were observed in the appearance of renal tissues in rats exposed to 3000 ppm 1-methoxy-2-propyl acetate. Slight to moderate degeneration of the olfactory epithelium in the nasal cavities was seen in rats and in mice. 1-Methoxy-2-propyl acetate had no adverse effect on reproductive parameters in rat developmental studies. 1-Methoxy-2-propyl acetate did not induce mutations or toxicity in Salmonella typhimurium strains TA98, TA100, TA1535, or TA1537 or in Escherichia coli WP2 uvrA, with or without metabolic activation.

LD50 Rabbit dermal >5 g/kg|LD50 Mouse ip 750 mg/kg|LD50 Rat (female) oral 8532 mg/kg|LD50 Rat (male) oral >10,000 mg/kg

1-Methoxy-2-propyl acetate's production and use in surface coatings, inks and cleaners(1), and in house paint, home maintenance and in auto finishing products(2) may result in its release to the environment through various waste streams(SRC).

TERRESTRIAL FATE: Based on a classification scheme(1), a measured log Koc of 0.362, corresponding to a Koc of 2.3(2) indicates that 1-methoxy-2-propyl acetate is expected to have very high mobility in soil(SRC). Volatilization of 1-methoxy-2-propyl acetate from moist soil surfaces is expected to be an important fate process(SRC) given an estimated Henry's Law constant of 3.4X10-6 atm-cu m/mole(SRC), based upon its vapor pressure, 3.92 mm Hg(3), and water solubility, 1.98X10+5 mg/L(2). 1-Methoxy-2-propyl acetate is expected to volatilize from dry soil surfaces(SRC) based upon its vapor pressure(2). 50% Biodegradation in less than one day using sandy and sandy loam soils(4) suggests that biodegradation is an important environmental fate process in soil(SRC).|AQUATIC FATE: Based on a classification scheme(1), a measured log Koc of 0.362, corresponding to a Koc of 2.3(2) indicates that 1-methoxy-2-propyl acetate is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(3) based upon an estimated Henry's Law constant of 3.4X10-6 atm-cu m/mole(SRC), derived from its vapor pressure, 3.92 mm Hg(4), and water solubility, 1.2X10+5 mg/L(2). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 12 and 93 days, respectively(SRC). According to a classification scheme(5), an estimated BCF of 3(SRC), from its log Kow of 0.56(2) and a regression-derived equation(6), suggests the potential for bioconcentration in aquatic organisms is low(SRC). 100% Biodegadation in the Zahn-Wellens test(7) indicates that biodegradation is an important environmental fate process in water(SRC).|ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), 1-methoxy-2-propyl acetate, which has a vapor pressure of 3.92 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase 1-methoxy-2-propyl acetate is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 32 hrs(SRC), calculated from its rate constant of 1.2X10-11 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). d(1); this corresponds to half-lives of 2.4 yrs and 88 days at pH values of 7 and 8, respectively(1). Using an atmospheric simulation chamber, no photolysis of 1-methoxy-2-propyl acetate was observed(4); therefore, the compound is not expected to be susceptible to direct photolysis by sunlight(SRC).

The rate constant for the vapor-phase reaction of 1-methoxy-2-propyl acetate with photochemically-produced hydroxyl radicals has been estimated as 1.2X10-11 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1). This corresponds to an atmospheric half-life of about 32 hours at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1). A base-catalyzed second-order hydrolysis rate constant of 9.1X10-2 L/mole-sec(SRC) was estimated using a structure estimation method(1); this corresponds to half-lives of 2.4 yrs and 88 days at pH values of 7 and 8, respectively(1). Using an atmospheric simulation chamber, no photolysis of 1-methoxy-2-propyl acetate was observed(2); therefore, the compound is not expected to be susceptible to direct photolysis by sunlight(SRC).|The rate coefficients for the reactions of OH and Cl with 1-methoxy 2-propyl acetate (MPA) in the gas phase were measured using absolute and relative methods. The kinetic study on the OH reaction was conducted in the temperature (263-373) K and pressure (1-760) Torr ranges using the pulsed laser photolysis-laser-induced fluorescence technique, a low pressure fast flow tube reactor-quadrupole mass spectrometer, and an atmospheric simulation chamber/GC-FID. The derived Arrhenius expression is kMPA+OH(T) = (2.01X10-12 exp[(588/T)] cm3 molecule-1 s-1. The absolute and relative rate coefficients for the reaction of Cl with MPA were measured at room temperature in the flow reactor and the atmospheric simulation chamber, which led to k(Cl+MPA) = (1.98X10-10 cm3 molecule-1 s-1. GC-FID, GC-MS, and FT-IR techniques were used to investigate the reaction mechanism in the presence of NO. The products formed from the reaction of MPA with OH and their yields were methyl formate (80%), acetic acid (50%), and acetic anhydride (22 %), while for Cl reaction, the obtained yields were 60, 41, and 11%, respectively, for the same products. The UV absorption cross section spectrum of MPA was determined in the wavelength range 210-370 nm. The study has shown no photolysis of MPA under atmospheric conditions. The obtained results are used to derive the atmospheric implication.

An estimated BCF of 3 was calculated in fish for 1-methoxy-2-propyl acetate(SRC), using a log Kow of 0.56(1) and a regression-derived equation(1). According to a classification scheme(2), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

2.29 L/kg|A measured log Koc of 0.362, corresponding to a Koc of 2.3, was reported for 1-methoxy-2-propyl acetate(1). According to a classification scheme(2), this estimated Koc value suggests that 1-methoxy-2-propyl acetate is expected to have very high mobility in soil(SRC).

The Henry's Law constant for 1-methoxy-2-propyl acetate is estimated as 3.4X10-6 atm-cu m/mole(SRC) derived from its vapor pressure, 3.92 mm Hg(1), and water solubility, 1.98X10+5 mg/L(2). This Henry's Law constant indicates that 1-methoxy-2-propyl acetate is expected to volatilize from water surfaces(3). Based on this Henry's Law constant, the volatilization half-life from a model river (1 m deep, flowing 1 m/sec, wind velocity of 3 m/sec)(3) is estimated as 12 days(SRC). The volatilization half-life from a model lake (1 m deep, flowing 0.05 m/sec, wind velocity of 0.5 m/sec)(3) is estimated as 93 days(SRC). 1-Methoxy-2-propyl acetate's estimated Henry's Law constant indicates that volatilization from moist soil surfaces may occur(SRC). The potential for volatilization of 1-methoxy-2-propyl acetate from dry soil surfaces may exist(SRC) based upon its vapor pressure(1).

According to the 2016 TSCA Inventory Update Reporting data, 33 reporting facilities estimate the number of persons reasonably likely to be exposed during the manufacturing, processing, or use of 1-methoxy-2-propyl acetate in the United States may be as low as 10 workers and as high as 10,000; the data may be greatly underestimated due to confidential business information (CBI) or unknown values(1).|NIOSH (NOES Survey 1981-1983) has statistically estimated that 345,446 workers (40,133 of these are female) were potentially exposed to 1-methoxy-2-propyl acetate in the US(1). Occupational exposure to 1-methoxy-2-propyl acetate may occur through inhalation and dermal contact with this compound at workplaces where 1-methoxy-2-propyl acetate is produced or used. Use data indicate that the general population may be exposed to 1-methoxy-2-propyl acetate via inhalation of and dermal contact with consumer products containing 1-methoxy-2-propyl acetate(SRC).

At the end of a workweek 23 silkscreen printers gave a urine sample for capillary gas chromatographic analysis for 1,2-propanediol. The mean concentration was 2.52 (S.D. 2.01) mmol mol creatinine(-1) (median=1.76, n=23). The urinary excretion of 1,2-propanediol was linearly dependent on the preceding 1-methoxy-2-propanol exposure measured in the worker's breathing zone [y=0.99+0.28x, n=23, r=0.67, where y is the urinary 1,2-propanediol concentration, in mmol mol creatinine(-1) and x is the concentration, in cm3 m(-3), of 1-methoxy-2-propanol (90.2%), 1-ethoxy-2-propyl acetate (5.8%), 1-methoxy-2-propyl acetate (2.1%) and 1-ethoxy-2-propanol (1.9%) in the air].|Personal air sampling for fluorides and solvents was done at 35 semiconductor fabrication facilities in the United States. Fluoride compounds were used in etching and cleaning operations, and solvents were used in photoresist and developing operations. All personal solvent and fluoride levels were less than 2 percent of current Occupational Safety and Health Administration (OSHA) standards. Statistical models of the exposure determinants for the target agents found production level, as indicated by number of semiconductor wafer cassettes loaded/unloaded from the target machines or baths, was predictive of fluoride, xylene and 1-methoxy-2-propyl acetate exposures. The percent of fresh air ventilation and the percent of xylene in the photoresist were also significant determinants in the statistical model predicting personal xylene exposure levels.

Male rats (number not given) were given a single oral dose of 8.7 mmol/kg [1-(14)C]methoxyisopropyl acetate. Approximately 64% of the administered radioactivity was exhaled as (14)CO2and 24% was excreted in urine within 48 hr of the oral dose. Free methoxyisopropanol and methoxyisopropanol sulfate and glucuronide conjugates were identified in the urine.|... Male F344 rats (number not given) were exposed to 3000 ppm [1-(14)C]methoxyisopropyl acetate in an inhalation chamber for 6 hr. Approximately 53% of the administered radioactivity was exhaled as (14)CO2,and 26% was excreted in urine within 48 hr of the end of the inhalation expo sure period. Methoxyisopropanol and sulfate and glucuronide conjugates were identified in the urine.|... The rate of hydrolysis of methoxyisopropyl acetate by carboxylesterase /were measured/ in the nasal mucosa of mice, rats, rabbits, and dogs. Samples of nasal mucosal tissue from each species were incubated in vials with 1.0 to 23 mM methoxyisopropyl acetate for 10 min, and then centrifuged. The supernatant was removed and analyzed by gas chromatography to measure the methoxyisopropanol content. The apparent Vmax and Km for the hydrolysis of methoxyisopropyl acetate were 0.080 x 10(-3) M/min and 2.67 x 10(-3) M, respectively.|... Male F344 rats /were given/ an intravenous injection of 10 or 100 mg/kg methoxyisopropanol or 14.7 or 147 mg/kg methoxyisopropyl acetate into an indwelling jugular vein cannula (number of animals per treatment not reported). Blood samples from the jugular vein cannulae were collected 5, 10, 15, 30, and 45 min and 1, 2, 4, 6, 8, and 12 hr after injection. The blood time courses of methoxyisopropanol elimination for both doses of both compounds were identical. The /half-life/ values for the low and high doses of methoxyisopropyl acetate were 1.6 and 2.3 min, respectively. The clearance rates of 14.7 and 147 mg/kg methoxyisopropyl acetate were 4 and 11.0 mL/min, respectively.

Male rats (number not given) were given a single oral dose of 8.7 mmol/kg [1-(14)C]methoxyisopropyl acetate. Approximately 64% of the administered radioactivity was exhaled as (14)CO2and 24% was excreted in urine within 48 hr of the oral dose. Free methoxyisopropanol and methoxyisopropanol sulfate and glucuronide conjugates were identified in the urine.|... Male F344 rats (number not given) were exposed to 3000 ppm [1-(14)C]methoxyisopropyl acetate in an inhalation chamber for 6 hr. Approximately 53% of the administered radioactivity was exhaled as (14)CO2,and 26% was excreted in urine within 48 hr of the end of the inhalation expo sure period. Methoxyisopropanol and sulfate and glucuronide conjugates were identified in the urine.|... The rate of hydrolysis of methoxyisopropyl acetate by carboxylesterase /were measured/ in the nasal mucosa of mice, rats, rabbits, and dogs. Samples of nasal mucosal tissue from each species were incubated in vials with 1.0 to 23 mM methoxyisopropyl acetate for 10 min, and then centrifuged. The supernatant was removed and analyzed by gas chromatography to measure the methoxyisopropanol content. The apparent Vmax and Km for the hydrolysis of methoxyisopropyl acetate were 0.080 x 10(-3) M/min and 2.67 x 10(-3) M, respectively.|The similarities between the metabolism and disposition of methoxyisopropyl acetate and those previously observed in methoxyisopropanol indicated that methoxyisopropyl acetate is rapidly hydrolyzed to methoxyisopropanol.|For more Metabolism/Metabolites (Complete) data for 1-Methoxy-2-propyl acetate (6 total), please visit the HSDB record page.

... Male F344 rats /were given/ an intravenous injection of 10 or 100 mg/kg methoxyisopropanol or 14.7 or 147 mg/kg methoxyisopropyl acetate into an indwelling jugular vein cannula (number of animals per treatment not reported). ... The /half-life/ values for the low and high doses of methoxyisopropyl acetate were 1.6 and 2.3 min, respectively.|... Rat blood and liver homogenate /were incubated/ with 5 or 50 ug/mL methoxyisopropyl acetate and ... the in vitro hydrolysis rate of methoxyisopropyl acetate to methoxyisopropanol /was measured/ in each tissue type. The hydrolysis /half-life/ values of methoxyisopropyl acetate in whole rat blood was 16 and 15 min with the 5 and 50 ug/mL concentrations, respectively. The /half-life/ of methoxyisopropyl acetate hydrolysis in rat liver homogenate was 34 min for both concentrations.|... Human whole blood and liver homogenate /was incubated/ with 5 or 50 ug/mL methoxyisopropyl acetate and ... the in vitro hydrolysis rate of methoxyisopropyl acetate to methoxyisopropanol /was measured/ in each tissue type. The hydrolysis half-lives of methoxyisopropyl acetate in whole blood was 36 and 34 min with the 5 and 50 ug/mL concentrations, respectively. The /half-life/, of methoxyisopropyl acetate hydrolysis in human liver homogenate was 27 to 30 min for both concentrations.

Methoxyisopropyl acetate may contain less than 0.5% of the alpha-isomer, 2-methoxy-1-propyl acetate and 0.2% propanol.

No significant adverse effects expected. (USCG, 1999)

Call for medical aid. EYES: Wash with water for 15 min.; call a physician. SKIN: Remove contaminated clothing and wash skin with soap and water. INGESTION: Induce vomiting after drinking two glasses of water. (USCG, 1999)

Fresh air, rest. Refer for medical attention.

Remove contaminated clothes. Rinse skin with plenty of water or shower.

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

/SRP:/ Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Esters and related compounds/|/SRP:/ Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilation if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 mL/kg up to 200 mL of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal ... . /Esters and related compounds/|/SRP:/ Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in severe respiratory distress. Positive-pressure ventilation techniques with a bag-valve-mask device may be beneficial. Consider drug therapy for pulmonary edema ... . Monitor cardiac rhythm and treat arrhythmias if necessary ... . Start IV administration of D5W TKO /SRP: "To keep open", minimal flow rate/. Use 0.9% saline (NS) or lactated Ringer's (LR) if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously. Consider vasopressors if patient is hypotensive with a normal fluid volume. Watch for signs of fluid overload ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Esters and related compounds/

/SIGNS AND SYMPTOMS/ The substance defats the skin, which may cause dryness or cracking.|/SIGNS AND SYMPTOMS/ The substance is irritating to the eyes and respiratory tract. Exposure at high levels could cause depression of the central nervous system.

methoxypropyl acetate

The substance can be absorbed into the body by inhalation of its aerosol or vapour and by ingestion.

Cough. Dizziness. Drowsiness. Headache. Nausea. Sore throat.

Dry skin.

Redness. Pain.

Adhesive manufacturing|2-Propanol, 1-methoxy-, 2-acetate: ACTIVE|PMN - indicates a commenced PMN (Pre-Manufacture Notices) substance.

Method: NIOSH 2554, Issue 1; Procedure: gas chromatography with flame ionization detector; Analyte: 1-Methoxy-2-propyl acetate; Matrix: air; Detection Limit: 0.5 ug.

EPA Safer Chemical Functional Use Classes -> Solvents|Safer Chemical Classes -> Green circle - The chemical has been verified to be of low concern|Cosmetics -> Solvent