sec-Butyl acetate

116.15800

116.16

203-300-1

0840

8034

1123

DTXSID0047612

Colorless liquid

2915390090

26.30000

1.34800

Watery colorless liquid with a pleasant, fruity odor. Floats on water. Produces irritating vapor. (USCG, 1999)

0.8748 g/cm³ @ Temp: 20 °C

-98.9 °C

112 °C

16ºC

1.388-1.39

H2O: 3 g/100 mL (20 ºC)

Flammables area

21.6mmHg at 25°C

4 (vs air)

Class IB Flammable Liquid: Fl.P. below 73°F and BP at or above 100°F.

vol% in air: 1.7.8

HAS FRUITY ODOR CHARACTERISTIC OF ACETATE ESTERS

5.50e-12 cm3/molecule*sec

Henry's Law constant = 4.2X10-4 atm-cu m/mole at 25 °C (est)

Conversion factors (wt/vol): 4.74 mg/cu m is equivalent to 1 ppm|Specific optical rotation: 25.43 deg at 20 °C/D; bp: 112 °C; density: 0.8758 at 16 °C/4 °C; Index of refraction: 1.3877 at 20 °C/D /d-Form/|Index of refraction: 1.3899 at 18 °C/D; specific optical rotation: -20.2 deg at 19 °C/546 nm (c = 5); bp: 116-7 °C; density 0.87301 at 19 °C/4 °C /l-Form/|Liquid. Specific gravity: 0.865 at 25 °C/4 °C; bp: 112-113 °C0; Index of refraction: 1.3866 at 25 °C/D. Slightly soluble in water, soluble in alcohol, ether. /dl-form/|Liquid; bp: 116-117 °C; specific gravity: 0.873 at 20 °C/4 °C; Index of refraction: 1.3899 at 18 °C/D /d-form/|Wt/gal: 7.21 lb|Softens and dissolves many plastics.|Liquid-water interfacial tension: (est) 58 dynes/cm = 0.058 N/m at 17 °C; Ratio of specific heats of vapor (gas): 1.061|... The odor of sec-butyl acetate is reported as milder than that of the primary isomers.|Azeotrope 77.5 wt% at 87 °C|Hydroxyl radical reaction rate constant = 5.5X10-12 cu cm/molecule-sec at 25 °C

Highly flammable. Water soluble.

Esters, Sulfate Esters, Phosphate Esters, Thiophosphate Esters, and Borate Esters

Highly Flammable

SEC-BUTYL ACETATE is an ester. Esters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides. Dissolves rubber and plastics (USCG, 1999).

-13,100 BTU/lb = -7300 cal/g = -305X10+5 J/kg (est)

9.91 eV

Lower flammable limit: 1.7% by volume; Upper flammable limit: 9.8% by volume|Class IB Flammable Liquid: Fl.P. below 73°F and BP at or above 100°F.

The vapour mixes well with air, explosive mixtures are easily formed.

130 BTU/lb = 74 cal/g = 3.1X10+5 J/kg (est)

Critical temperature: 571.1 K; critical pressure: 3.01 MPa

III

3

UN 1123

3

R11; R66

S16-S23-S25-S29-S33

AF7380000

F

Fireproof. Separated from strong oxidants, strong bases and strong acids.

SOFTENS AT RELATIVELY LOW TEMPERATURES BUT IS RELATIVELY STABLE IN LIGHT AND OXYGEN

P210-P305 + P351 + P338-P370 + P378-P403 + P235

H225-H315-H319

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal and plant life; and conformance with environmental and public health regulations.|/Proposed methods of disposal should be used on statutory requirements of the state where disposal is to occur. The usual methods would be expected to include:/ 1) Absorbing in vermiculite, dry sand, earth or a similar material and disposing in a secured sanitary landfill. 2) Atomizing in a suitable combustion chamber.|SRP: Wastewater from contaminant suppression, cleaning of protective clothing/equipment, or contaminated sites should be contained and evaluated for subject chemical or decomposition product concentrations. Concentrations shall be lower than applicable environmental discharge or disposal criteria. Alternatively, pretreatment and/or discharge to a permitted wastewater treatment facility is acceptable only after review by the governing authority and assurance that "pass through" violations will not occur. Due consideration shall be given to remediation worker exposure (inhalation, dermal and ingestion) as well as fate during treatment, transfer and disposal. If it is not practicable to manage the chemical in this fashion, it must be evaluated in accordance with EPA 40 CFR Part 261, specifically Subpart B, in order to determine the appropriate local, state and federal requirements for disposal.

Contact with nitrates, strong oxidizers, strong alkalies, and strong acids may cause fires and explosions.|Nitrates; strong oxidizers, alkalis and acids.

Excerpt from ERG Guide 129 [Flammable Liquids (Water-Miscible / Noxious)]: HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Those substances designated with a (P) may polymerize explosively when heated or involved in a fire. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water. (ERG, 2016)|Highly flammable. Vapour/air mixtures are explosive.|Flammable - 3rd degree

|Danger|H225 (99.67%): Highly Flammable liquid and vapor [Danger Flammable liquids]|P210, P233, P240, P241, P242, P243, P280, P303+P361+P353, P370+P378, P403+P235, and P501|Aggregated GHS information provided by 321 companies from 7 notifications to the ECHA C&L Inventory.|H225: Highly Flammable liquid and vapor [Danger Flammable liquids]|P210, P233, P240, P241, P242, P243, P261, P264, P271, P280, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P370+P378, P403+P233, P403+P235, P405, and P501|P210, P233, P240, P241, P242, P243, P260, P261, P264, P270, P271, P280, P303+P361+P353, P304+P340, P305+P351+P338, P309+P311, P312, P332+P313, P337+P313, P370+P378, P403+P233, P403+P235, P405, and P501

Excerpt from ERG Guide 129 [Flammable Liquids (Water-Miscible / Noxious)]: As an immediate precautionary measure, isolate spill or leak area for at least 50 meters (150 feet) in all directions. LARGE SPILL: Consider initial downwind evacuation for at least 300 meters (1000 feet). FIRE: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2016)

Excerpt from ERG Guide 129 [Flammable Liquids (Water-Miscible / Noxious)]: ELIMINATE all ignition sources (no smoking, flares, sparks or flames in immediate area). All equipment used when handling the product must be grounded. Do not touch or walk through spilled material. Stop leak if you can do it without risk. Prevent entry into waterways, sewers, basements or confined areas. A vapor-suppressing foam may be used to reduce vapors. Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers. Use clean, non-sparking tools to collect absorbed material. LARGE SPILL: Dike far ahead of liquid spill for later disposal. Water spray may reduce vapor, but may not prevent ignition in closed spaces. (ERG, 2016)

Skin: Wear appropriate personal protective clothing to prevent skin contact. Eyes: Wear appropriate eye protection to prevent eye contact. Wash skin: The worker should immediately wash the skin when it becomes contaminated. Remove: Work clothing that becomes wet should be immediately removed due to its flammability hazard(i.e. for liquids with flash point Change: No recommendation is made specifying the need for the worker to change clothing after the work shift. (NIOSH, 2016)|Organic vapor canister or air-supplied mask; chemical goggles or face splash shield.|If the use of respirators is necessary, the only respirators permitted are those that have been approved by the Mine Safety and Health Administration (formerly Mining Enforcement and Safety Administration) or by the National Institute for Occupational Safety and Health.|Respiratory selection: At 1000 ppm or less: a chemical cartridge respirator with a full facepiece and an organic vapor cartridge; At 5000 ppm or less: A gas mask with a chin-style organic vapor canister; At 10,000 ppm or less: A gas mask with a chin-style or a front-or back- mounted organic vapor canister, any supplied-air respirator with a full facepiece, helmet, or hood, or any self-contained breathing apparatus with a full facepiece; Greater than 10,000 ppm or entry and escape from unknown concn: Self-contained breathing apparatus with a full facepiece operated in pressure-demand or other positive pressure mode, or a combination respirator which includes a type C supplied-air respirator with a full facepiece operated in pressure-demand or other positive pressure or continuous-flow mode and an auxiliary self-contained breathing apparatus operated in pressure-demand or other positive pressure mode; fire fighting: Self-contained breathing apparatus with a full facepiece operated in pressure-demand or other positive pressure mode; Escape: Any gas mask providing protection against organic vapors or any escape self-contained breathing apparatus.|Employees should be provided with and required to use impervious clothing, gloves, face shields (eight-inch minimum), and other appropriate clothing necessary to prevent repeated or prolonged skin contact with liquid sec-butyl acetate.|For more Personal Protective Equipment (PPE) (Complete) data for SEC-BUTYL ACETATE (11 total), please visit the HSDB record page.|(See protection codes)

Flammable liquid.

Vapor may explode if ignited in an enclosed area.|Lower explosive limit: 1.7%; Upper explosive limit: 9.8%|Explosive limits , vol% in air: 1.7-9.8

To fight fire, use alcohol foam, CO2, dry chemical.|If material on fire or involved in a fire: Do not extinguish fire unless flow can be stopped. Use water in flooding quantities as fog. Solid streams of water may spread fire. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible. Use foam, dry chemical, or carbon dioxide. /Butyl acetates/|Water may be ineffective on fire. Cool exposed containers with water.|Fire fighting: Use self-contained breathing apparatus with a full facepiece operated in pressure-demand or other positive pressure mode.

Flashback along vapor trail may occur.

1) Remove all ignition sources. 2) Ventilate area of spill or leak. 3) For small quantities, absorb on paper towels. Evaporate in safe place (such as fume hood). Allow sufficient time for evaporating vapors to completely clear hood ductwork. Burn paper towel in suitable location away from combustible materials. Large quantities may be collected & atomized in suitable combustion chamber. sec-Butyl acetate should not be allowed to enter a confined space, such as sewer, because of possibility of explosion.|/Absorb/ it in vermiculite, dry sand, earth or a similar material.|Environmental considerations: Land spill: Dig a pit, pond, lagoon, or holding area to contain liquid or solid material /SRP: If time permits, pits, ponds, lagoons, soak holes, or holding areas should be sealed with an impermeable flexible membrane liner./ Dike surface flow using soil, sand bags, foamed polyurethane, or foamed concrete. Absorb bulk liquid with fly ash or cement powder. Apply appropriate foam to diminish vapor and fire hazard. /Butyl acetates/|Environmental considerations: Water spill: Use natural barriers or oil spill control booms to limit spill travel. Use surface active agent (eg detergent, soaps, alcohols), if approved by EPA. Inject "universal" gelling agent to solidify encircled spill and increased effectiveness of booms. If dissolved, in region of 10 ppm or greater concentration, apply activated carbon at ten times the spilled amount. Remove trapped material with suction hoses. Use mechanical dredges or lifts to remove immobilized masses of pollutants and precipitates. /Butyl acetates/|Environmental considerations: Air spill: Apply water spray or mist to knock down vapors. /Butyl acetates/

SRP: The scientific literature for the use of contact lenses by industrial workers is inconsistent. The benefits or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.|THE BASIC VENTILATION METHODS ARE LOCAL EXHAUST VENTILATION AND DILUTION OR GENERAL VENTILATION.|Employees should wash promptly when skin is wet or contaminated. Remove clothing immediately if wet or contaminated to avoid flammability hazard.|... A complete respiratory protection program should be instituted which includes regular training, maintenance, inspection, cleaning, and evaluation. ... Clothing wet with liquid sec-butyl acetate should be placed in closed containers for storage until it can be discarded or until provision is made for the removal of sec-butyl acetate from the clothing. If the clothing is to be laundered, or otherwise cleaned to remove the sec-butyl acetate, the person performing the operation should be informed of sec-butyl acetate's hazardous properties.|For more Preventive Measures (Complete) data for SEC-BUTYL ACETATE (10 total), please visit the HSDB record page.

/GUIDE 129: FLAMMABLE LIQUIDS (POLAR/WATER-MISCIBLE/NOXIOUS)/ Fire or Explosion: HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Those substances designated with "P" may polymerize explosively when heated or involved in a fire. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water. /Butyl acetates/|/GUIDE 129: FLAMMABLE LIQUIDS (POLAR/WATER-MISCIBLE/NOXIOUS)/ Health: May cause toxic effects if inhaled or absorbed through skin. Inhalation or contact with material may irritate or burn skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution. /Butyl acetates/|/GUIDE 129: FLAMMABLE LIQUIDS (POLAR/WATER-MISCIBLE/NOXIOUS)/ Public Safety: CALL Emergency Response Telephone Number ... As an immediate precautionary measure, isolate spill or leak area for at least 50 meters (150 feet) in all directions. Keep unauthorized personnel away. Stay upwind. Keep out of low areas. Ventilate closed spaces before entering. /Butyl acetates/|/GUIDE 129: FLAMMABLE LIQUIDS (POLAR/WATER-MISCIBLE/NOXIOUS)/ Protective Clothing: Wear positive pressure self-contained breathing apparatus (SCBA). Structural firefighters' protective clothing will only provide limited protection. /Butyl acetates/|For more DOT Emergency Guidelines (Complete) data for SEC-BUTYL ACETATE (8 total), please visit the HSDB record page.

No person may /transport,/ offer or accept a hazardous material for transportation in commerce unless that person is registered in conformance ... and the hazardous material is properly classed, described, packaged, marked, labeled, and in condition for shipment as required or authorized by ... /the hazardous materials regulations (49 CFR 171-177)./|The International Air Transport Association (IATA) Dangerous Goods Regulations are published by the IATA Dangerous Goods Board pursuant to IATA Resolutions 618 and 619 and constitute a manual of industry carrier regulations to be followed by all IATA Member airlines when transporting hazardous materials.|The International Maritime Dangerous Goods Code lays down basic principles for transporting hazardous chemicals. Detailed recommendations for individual substances and a number of recommendations for good practice are included in the classes dealing with such substances. A general index of technical names has also been compiled. This index should always be consulted when attempting to locate the appropriate procedures to be used when shipping any substance or article.

Vapor is irritating to eyes, nose, & throat. Liquid is irritating to skin & eyes.

Permissible Exposure Limit: Table Z-1 8-hr Time Weighted Avg: 200 ppm (950 mg/cu m).

Recommended Exposure Limit: 10 Hour Time-Weighted Average: 200 ppm (950 mg/cu m).

Remove all ignition sources. Personal protection: filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Ventilation. Collect leaking liquid in sealable containers. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations. Do NOT wash away into sewer.

Fireproof. Separated from strong oxidants, strong bases and strong acids.

A harmful contamination of the air will be reached rather slowly on evaporation of this substance at 20 °C.

The vapour is mildly irritating to the eyes and respiratory tract. The substance may cause effects on the central nervous system. Exposure far above the OEL could cause lowering of consciousness.

The substance defats the skin, which may cause dryness or cracking.

NO open flames, NO sparks and NO smoking. Closed system, ventilation, explosion-proof electrical equipment and lighting. Do NOT use compressed air for filling, discharging, or handling.

Use ventilation, local exhaust or breathing protection.

Protective gloves.

Wear safety spectacles.

| 1 - Materials that, under emergency conditions, can cause significant irritation.| 3 - Liquids and solids that can be ignited under almost all ambient temperature conditions. Materials produce hazardous atmospheres with air under almost all ambient temperatures or, though unaffected by ambient temperatures, are readily ignited under almost all conditions.| 0 - Materials that in themselves are normally stable, even under fire conditions.

Persons in charge of vessels or facilities are required to notify the National Response Center (NRC) immediately, when there is a release of this designated hazardous substance, in an amount equal to or greater than its reportable quantity of 5000 lb or 2270 kg. The toll free number of the NRC is (800) 424-8802. The rule for determining when notification is required is stated in 40 CFR 302.4 (section IV. D.3.b).

INDOOR AIR: sec-Butyl acetate was detected at an average concentration of 2 ug/cu m in West German homes(1).

... Volatiles formed during fringe process and during a continuous process of malt vinegar manufacture /were measured/. ... sec-Butyl acetate ... was detected during the /initial/ alcoholic fermentation.|sec-Butyl acetate's production and use as a solvent for nitrocellulose lacquers, thinners and leather finishes(1) may lead to its release to the environment through various waste streams(SRC).

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 16(SRC), determined from a structure estimation method(2), indicates that sec-butyl acetate is expected to have very high mobility in soil(SRC). Volatilization of sec-butyl acetate from moist soil surfaces is expected to be an important fate process(SRC) given an estimated Henry's Law constant of 4.2X10-4 atm-cu m/mole(SRC), based upon its vapor pressure, 17 mm Hg(3), and water solubility, 6200 mg/L(4). sec-Butyl acetate is expected to volatilize from dry soil surfaces(SRC) based upon its vapor pressure(3). A value of 86% of theoretical BOD using activated sludge in the Japanese MITI test(5) suggests that biodegradation is an important environmental fate process in soil(SRC).|AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 16(SRC), determined from a structure estimation method(2), indicates that sec-butyl acetate is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(3) based upon an estimated Henry's Law constant of 4.2X10-4 atm-cu m/mole(SRC), derived from its vapor pressure, 17 mm Hg(4), and water solubility, 6200 mg/L(5). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 5.4 hours and 5 days, respectively(SRC). According to a classification scheme(6), an estimated BCF of 6(SRC), from its log Kow of 1.72(7) and a regression-derived equation(8), suggests the potential for bioconcentration in aquatic organisms is low(SRC). A value of 86% of theoretical BOD using activated sludge in the Japanese MITI test(9) suggests that biodegradation is an important environmental fate process in water(SRC). Hydrolysis is expected to occur slowly based upon estimated hydrolysis half-lives of 3.5 years and 128 days at pH 7 and 8, respectively(10).|ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), sec-butyl acetate, which has a vapor pressure of 17 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase sec-butyl acetate is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 70 hours(SRC), calculated from its rate constant of 5.5X10-12 cu cm/molecule-sec at 25 °C(3). sec-Butyl acetate does not contain chromophores that absorb at wavelengths >290 nm(4) and therefore is not expected to be susceptible to direct photolysis by sunlight(SRC).

The rate constant for the vapor-phase reaction of sec-butyl acetate with photochemically-produced hydroxyl radicals has been reported as 5.5X10-12 cu cm/molecule-sec at 25 °C(1). This corresponds to an atmospheric half-life of about 70 hours at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1). A base-catalyzed second-order hydrolysis rate constant of 0.06 L/mole-sec(SRC) was estimated using a structure estimation method(2); this corresponds to half-lives of 3.5 years and 128 days at pH values of 7 and 8, respectively(2). sec-Butyl acetate does not contain chromophores that absorb at wavelengths >290 nm(3) and therefore is not expected to be susceptible to direct photolysis by sunlight(SRC).

An estimated BCF of 6 was calculated in fish for sec-butyl acetate(SRC), using a log Kow of 1.72(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

Using a structure estimation method based on molecular connectivity indices(1), the Koc of sec-butyl acetate can be estimated to be 16(SRC). According to a classification scheme(2), this estimated Koc value suggests that sec-butyl acetate is expected to have very high mobility in soil.

The Henry's Law constant for sec-butyl acetate is estimated as 4.2X10-4 atm-cu m/mole(SRC) derived from its vapor pressure, 17 mm Hg(1), and water solubility, 6200 mg/L(2). This Henry's Law constant indicates that sec-butyl acetate is expected to volatilize from water surfaces(3). Based on this Henry's Law constant, the volatilization half-life from a model river (1 m deep, flowing 1 m/sec, wind velocity of 3 m/sec)(3) is estimated as 5.4 hours(SRC). The volatilization half-life from a model lake (1 m deep, flowing 0.05 m/sec, wind velocity of 0.5 m/sec)(3) is estimated as 5 days(SRC). sec-Butyl acetate's estimated Henry's Law constant indicates that volatilization from moist soil surfaces may occur(SRC). The potential for volatilization of sec-butyl acetate from dry soil surfaces may exist(SRC) based upon its vapor pressure(1).

SURFACE WATER: sec-Butyl acetate was identified, not quantified, in 1 of 8 rivers sampled in West Germany(1).

sec-Butyl acetate was identified, not quantified, as a volatile flavor component of baked potatoes(1), Beaufort cheese(2), and Gruyere type cheese made in the French Alps(2).

Inhalation, ingestion, skin, and eye contact.|According to the 2006 TSCA Inventory Update Report, the number of workers reasonably likely to be exposed in the industrial manufacturing, processing, and use for sec-butyl acetate is 1 to 99 persons; the data may be greatly underestimated(1).|Occupational exposure to sec-butyl acetate may occur through inhalation and dermal contact with this compound at workplaces where sec-butyl acetate is produced or used. Monitoring data indicate that the general population may be exposed to sec-butyl acetate via ingestion of food containing this compound. (SRC)

Butyl acetates are readily hydrolyzed to acid and alcohol in blood, liver, small intestines and respiratory passages, and this has been demonstrated in vitro in homogenates. ... /butyl acetates/

Acetic acid up to 0.2%

Headaches, dizziness, nausea, irritation of respiratory passage and eyes. (USCG, 1999)

Eye: If this chemical contacts the eyes, immediately wash the eyes with large amounts of water, occasionally lifting the lower and upper lids. Get medical attention immediately. Contact lenses should not be worn when working with this chemical. Skin: If this chemical contacts the skin, flush the contaminated skin with water promptly. If this chemical penetrates the clothing, immediately remove the clothing and flush the skin with water promptly. If irritation persists after washing, get medical attention. Breathing: If a person breathes large amounts of this chemical, move the exposed person to fresh air at once. If breathing has stopped, perform mouth-to-mouth resuscitation. Keep the affected person warm and at rest. Get medical attention as soon as possible. Swallow: If this chemical has been swallowed, get medical attention immediately. (NIOSH, 2016)|(See procedures)

Fresh air, rest. Refer for medical attention.

Remove contaminated clothes. Rinse and then wash skin with water and soap.

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Esters and related compounds/|Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Provide a low-stimulus environment. Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 mL/kg up to 200 mL of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool ... . Treat frostbite by rapid rewarming ... . /Esters and related compounds/|Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in severe respiratory distress. Positive-pressure ventilation techniques with a bag-valve-mask device may be beneficial. Consider drug therapy for pulmonary edema ... . Monitor cardiac rhythm and treat arrhythmias if necessary ... . Start IV administration of D5W /SRP: "To keep open", minimal flow rate/. Use 0.9% saline (NS) or lactated Ringer's (LR) if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously. Consider vasopressors if patient is hypotensive with a normal fluid volume. Watch for signs of fluid overload ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Esters and related compounds/

/HUMAN EXPOSURE STUDIES/ A study of sensory irritation (nasal pungency) associated with a series of homologous ketones and secondary and tertiary alcohols and esters was conducted. The study group consisted of three men and one woman, 41 to 65 years old, who lacked a sense of smell (anosmics) and three men and one woman 41 to 68 years old, with normal olfaction (normosmics). The subjects were exposed to 2-propanone (67641), 2-pentanone (107879), 2-heptanone (110430), 2-nonanone (821556), 2-propanol (67630), 2-methyl-2-propanol (75650), 2-butanol (78922), 4-heptanol (589559), tert-butyl-acetate (540885), and sec-butyl-acetate (105464) vapors at concentrations of 1x10-2 to 1x10+6 ppm by sniffing bottles containing the solvents. They also sniffed bottles containing a blank (nonodoriferous solvent). The subjects were asked to estimate the concentration of each solvent at which they could first detect the odor and perceive nasal pungency. Attempts were made to correlate the thresholds with the concentration of the saturated vapor at ambient temperature (23 °C). Both the normosmics and anosmics could detect the solvent vapors; however, the normosmics detected the vapors at much lower concentrations. The nasal pungency and odor thresholds of the ketones decreased with increasing carbon chain length, but tended to plateau at 2-heptanone. The odor and pungency thresholds of the alcohols tended to increase when the hydroxy group was changed from a primary to a secondary carbon atom. The odor and pungency thresholds of the esters were similar. When plotted against the logarithm of the saturation vapor concentration, the logarithm of the pungency thresholds of the compounds conformed to a linear function that was approximately parallel to the saturation vapor concentration. No association between odor threshold and saturation vapor concentration was seen. The authors conclude that anosmics as well as normosmics can detect odors of volatile organic compounds, although at different concentrations. The pungency threshold data suggest that physical rather than chemical factors are involved in the interaction of volatile organic compounds with the nasal mucosa.|/SIGNS AND SYMPTOMS/ Overexposure to sec-butyl acetate may cause irritation of the eyes, nose, and throat. Severe overexposure may cause weakness, drowsiness, and unconsciousness. Prolonged overexposure may produce irritation of the skin.|/SIGNS AND SYMPTOMS/ Vapors cause slight smarting of the eyes or resp system if present in high concn. ... If spilled on clothing and allowed to remain may cause smarting and reddening of the skin.|/SIGNS AND SYMPTOMS/ In man, exposure to concentrations of 950 ppm for 30 min causes irritation of the nose and eyes, headaches and weakness. The principal symptoms in cases of occupational exposure are headaches and irritation of the mucous membranes of the nose and of the conjunctiva. Other symptoms mentioned include vertigo, palpitations, gastrointestinal disorders, anaemia, cutaneous lesions, dermatitis and affections of the liver.|For more Human Toxicity Excerpts (Complete) data for SEC-BUTYL ACETATE (6 total), please visit the HSDB record page.

The substance can be absorbed into the body by inhalation of its vapour.|inhalation, ingestion, skin and/or eye contact

irritation eyes; headache; drowsiness; dryness upper respiratory system, skin; narcosis

Cough. Sore throat. Dizziness. Headache.

Dry skin.

Redness.

Eyes, skin, respiratory system, central nervous system

ESSENTIALLY 100% AS A SOLVENT (1976)

Grade or purity: technical and pure

Acetic acid, 1-methylpropyl ester: ACTIVE

Method: NIOSH 1450, Issue 3; Procedure: gas chromatography with flame ionization; Analyte: sec-butyl acetate; Matrix: air; Detection Limit: 0.9 ug/sample.|Method: OSHA 1009; Procedure: gas chromatography with flame ionization detector; Analyte: sec-butyl acetate; Matrix: air; Detection Limit: 27.7 picograms.|A gas chromatographic method for the analysis of n-butyl acetate, consists of a stainless steel column, 3 m x 3 mm, packed with Chromosorb WHP (100/120 mesh) coated with 5% FFAP, with hydrogen-air flame ionization detection, and nitrogen as the carrier gas at a flow rate of 30 mL/min, is a NIOSH approved method. A sample injection volume of 5 uL is suggested, the column temperature is 60 °C and a detector temperature of 250 °C. This method has a detection limit of 0.02 mg/L and a relative standard deviation of 0.02, over a working range of 95-2850 mg/cu m for a 10 liter sample.

Food additives -> Flavoring Agents|Fire Hazards -> Flammable - 3rd degree

Flavoring Agents