Butyl chloride

92.56730

92.57

203-696-6

ZP7R667SGD

0703

8419

1127

DTXSID8020206

COLORLESS LIQ

2903299090

0

2.02530

Butyl chloride appears as a water white liquid with a sharp odor. Flash point 20°F. Boiling point 77-78°C (173°F). Density 7.5 lb / gal. Slightly soluble in water. Vapors are heavier than air. Used in the manufacture of a variety of organic chemicals.

0.88648 g/cm³ @ Temp: 20 °C

-123.1 °C

78.5 °C @ Press: 760 Torr

-12ºC

1.4014-1.4034

water: soluble 0.11g/L at 20°C

2-8ºC

103mmHg at 25°C

Relative vapour density (air = 1): 3.2

LD50 orally in rats: 2.67 g/kg (Smyth)

LOWER FLAMMABLE LIMIT 1.8 % BY VOLUME; UPPER FLAMMABLE LIMIT 10.1 % BY VOLUME

vol% in air: 1.80.1

Unpleasant

1.50e-12 cm3/molecule*sec

0.02 atm-m3/mole

1 GAL WEIGHS 7.35 LB; DIPOLE MOMENT: 1.95

Highly flammable. May react with atmospheric moisture over prolonged periods of exposure. Slightly soluble in water.

Halogenated Organic Compounds

Highly Flammable

BUTYL CHLORIDE is incompatible with oxidizing agents and strong bases. Reacts with aluminum powder, magnesium, liquid oxygen, potassium and sodium (NTP, 1992). Emits phosgene gas when heated to decomposition. May be sensitive to heat.

860 °F (USCG, 1999)|860 °F (460 °C)|245 °C

LOWER FLAMMABLE LIMIT 1.8 % BY VOLUME; UPPER FLAMMABLE LIMIT 10.1 % BY VOLUME

The vapour is heavier than air and may travel along the ground; distant ignition possible. As a result of flow, agitation, etc., electrostatic charges can be generated.

30.39 KJ/mol

Critical temperature: 269 °C

II

3

UN 1127

2

R11

S16-S29-S9

EJ6300000

F

Fireproof. Separated from incompatible materials. See Chemical Dangers. Well closed.

Stable. Highly flammable. Note low flash point and wide explosion limit range. Incompatible with strong oxidizing agents, strong bases.

P210-P273-P301 + P310-P331-P403 + P235

H225-H304-H412

Specification and dosage requirements for n-butyl chloride are given in detail for the removal of ascarids and hookworms in dogs, puppies, cats, and kittens.

DHHS/NTP; Toxicology & Carcinogenesis Studies of n-Butyl Chloride in F344/N Rats and B6C3F1 Mice Technical Report Series No. 312 (1986) NIH Publication No. 86-2568

Special Hazards of Combustion Products: May produce phosgene gas in fire (USCG, 1999)|Highly flammable. Gives off irritating or toxic fumes (or gases) in a fire. Vapour/air mixtures are explosive.|Flammable - 3rd degree

|Danger|H225: Highly Flammable liquid and vapor [Danger Flammable liquids]|P210, P233, P240, P241, P242, P243, P280, P303+P361+P353, P370+P378, P403+P235, and P501|P201, P202, P210, P233, P240, P241, P242, P243, P264, P280, P281, P302+P352, P303+P361+P353, P305+P351+P338, P308+P313, P321, P332+P313, P337+P313, P362, P370+P378, P403+P235, P405, and P501

Excerpt from ERG Guide 130 [Flammable Liquids (Water-Immiscible / Noxious)]: As an immediate precautionary measure, isolate spill or leak area for at least 50 meters (150 feet) in all directions. LARGE SPILL: Consider initial downwind evacuation for at least 300 meters (1000 feet). FIRE: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2016)

Excerpt from ERG Guide 130 [Flammable Liquids (Water-Immiscible / Noxious)]: ELIMINATE all ignition sources (no smoking, flares, sparks or flames in immediate area). All equipment used when handling the product must be grounded. Do not touch or walk through spilled material. Stop leak if you can do it without risk. Prevent entry into waterways, sewers, basements or confined areas. A vapor-suppressing foam may be used to reduce vapors. Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers. Use clean, non-sparking tools to collect absorbed material. LARGE SPILL: Dike far ahead of liquid spill for later disposal. Water spray may reduce vapor, but may not prevent ignition in closed spaces. (ERG, 2016)

Approved respirator, chemical safety goggles, rubber gloves, other protective clothing. (USCG, 1999)

FLAMMABLE, DANGEROUS FIRE RISK.

Lower explosive limit= 1.9%; Upper explosive limit= 10.1%|Moderate, when exposed to flame.|Explosive limits , vol% in air: 1.8-10.1

To fight fire: Foam, carbon dioxide, dry chemical.|If material /is/ on fire or involved in /a/ fire do not extinguish fire unless flow can be stopped. Use water in flooding quantities as fog. Solid streams of water may spread fire. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible. Use foam, dry chemial or carbon dioxide.|If fire becomes uncontrollable or container is exposed to direct flame-consider evacuation of one-third (1/3) mile radius.

If material /is/ not on fire and not involved in /a/ fire keep sparks, flames, and other sources of ignition away. Keep material out of water sources and sewers. Build dikes to contain flow as necessary. Attempt to stop leak if without undue personnel hazard. Use water spray to knock-down vapors.|Avoid breathing vapors. Keep upwind. Do not handle broken packages unless wearing appropriate personal protective equipment. Wash away any material which may have contacted the body with copious amounts of water or soap and water.|If material leaking (not on fire) consider evacuation from downwind area based on amount of material spilled, location and weather conditions.|SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.

/GUIDE 130: FLAMMABLE LIQUIDS (Non-Polar/Water-Immiscible/Noxious)/ Fire or Explosion: HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Those substances designated with a (P) may polymerize explosively when heated or involved in a fire. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.|/GUIDE 130: FLAMMABLE LIQUIDS (Non-Polar/Water-Immiscible/Noxious)/ Health: May cause toxic effects if inhaled or absorbed through skin. Inhalation or contact with material may irritate or burn skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution.|/GUIDE 130: FLAMMABLE LIQUIDS (Non-Polar/Water-Immiscible/Noxious)/ Public Safety: CALL Emergency Response Telephone Number on Shipping Paper first. If Shipping Paper not available or no answer, refer to appropriate telephone number listed on the inside back cover. As an immediate precautionary measure, isolate spill or leak area for at least 50 meters (150 feet) in all directions. Keep unauthorized personnel away. Stay upwind. Keep out of low areas. Ventilate closed spaces before entering.|/GUIDE 130: FLAMMABLE LIQUIDS (Non-Polar/Water-Immiscible/Noxious)/ Protective Clothing: Wear positive pressure self-contained breathing apparatus (SCBA). Structural firefighters' protective clothing will only provide limited protection.|For more DOT Emergency Guidelines (Complete) data for N-BUTYL CHLORIDE (8 total), please visit the HSDB record page.

No person may /transport,/ offer or accept a hazardous material for transportation in commerce unless that person is registered in conformance ... and the hazardous material is properly classed, described, packaged, marked, labeled, and in condition for shipment as required or authorized by ... /the hazardous materials regulations (49 CFR 171-177)./|The International Air Transport Association (IATA) Dangerous Goods Regulations are published by the IATA Dangerous Goods Board pursuant to IATA Resolutions 618 and 619 and constitute a manual of industry carrier regulations to be followed by all IATA Member airlines when transporting hazardous materials.|The International Maritime Dangerous Goods Code lays down basic principles for transporting hazardous chemicals. Detailed recommendations for individual substances and a number of recommendations for good practice are included in the classes dealing with such substances. A general index of technical names has also been compiled. This index should always be consulted when attempting to locate the appropriate procedures to be used when shipping any substance or article.

Skin, eye irritant

Personal protection: filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations. Do NOT wash away into sewer. Do NOT let this chemical enter the environment.

Fireproof. Separated from incompatible materials. Well closed. Keep in a well-ventilated room. Store in an area without drain or sewer access. See Chemical Dangers.

A harmful contamination of the air can be reached very quickly on evaporation of this substance at 20 °C , especially on spraying.

The substance is irritating to the eyes, skin and respiratory tract. The substance may cause effects on the nervous system.

NO open flames, NO sparks and NO smoking. Closed system, ventilation, explosion-proof electrical equipment and lighting. Prevent build-up of electrostatic charges (e.g., by grounding). Do NOT use compressed air for filling, discharging, or handling.

PREVENT GENERATION OF MISTS!

Use ventilation, local exhaust or breathing protection.

Protective gloves.

Wear safety spectacles or eye protection in combination with breathing protection.

| 2 - Materials that, under emergency conditions, can cause temporary incapacitation or residual injury.| 3 - Liquids and solids that can be ignited under almost all ambient temperature conditions. Materials produce hazardous atmospheres with air under almost all ambient temperatures or, though unaffected by ambient temperatures, are readily ignited under almost all conditions.| 0 - Materials that in themselves are normally stable, even under fire conditions.

In a study of 63 industrial effluents that discharge into surface waters, chlorobutane was found in one effluent at a concentration of <10 ug/l(1).

SOURCE DOMINATED: n-Butyl chloride was identified, but not quantified, in one of 10 samples of ambient air in the Kanawna Valley, WV(1). Various locations were sampled during three trips.

LD50 Rat oral 2.67 g/kg

... Carcinogenesis studies of n-butyl chloride (greater than 99.5% pure) ... was conducted by exposing groups of F344/N rats and B6C3F1 mice to n-butyl chloride in corn oil by gavage for ... 2 yr. ... The 2 yr toxicology and carcinogenesis studies of n-butyl chloride were conducted by administering doses of 0, 60, or 120 mg/kg in corn oil by gavage to groups of 50 male and 50 female rats and doses of 0, 500, or 1,000 mg/kg to groups of 50 male and 50 female mice. ... Pheochromocytomas of the adrenal gland occurred at a marginally increased incidence in low dose female rats (1/50; 6/50; 1/49). Hyperplasia was observed in 3/50 vehicle controls, 7/50 low dose females, and 4/49 high dose females. The incidence of pheochromocytomas was low, not dose related, and not seen in male rats, and thus it was not considered to be cmpd related. ... An increased incidence of alveolar/bronchiolar adenomas or carcinomas (combined) was observed in the 500 mg/kg/group of female mice (3/50 vs 9/50), but little effect was seen in the 250 mg/kg group (6/50 vs 8/50). ... An increased incidence of hepatocellular adenomas or carcinomas (combined) was observed in the 500 mg/kg group of female mice (3/50 vs 8/50) but not in the 250 mg/kg (9/50 vs 7/50). ... Under the conditions of these 2 yr gavage studies, there was no evidence of carcinogenicity of n-butyl chloride for male and female F344/N rats at daily doses of 60 or 120 mg/kg, for male B6C3F1 mice at doses of 250, 500, or 1,000 mg/kg, or for female B6C3F1 mice at doses of 250 or 500 mg/kg. Chemical-induced toxicity in high dose rats (primarily females) reduced the sensitivity of the study for determining carcinogenicity.

n-Butyl chloride is used as a solvent, an alkylating agent, and an antihelmintic medicine(2). It may be released to the environment in emissions or wastewater related to its manufacture and these uses. n-Butyl chloride was formed during the chlorination of leachate obtained from a simulated landfill used to study the codisposal of metal plating sludge with municipal solid waste(1).

TERRESTRIAL FATE: n-Butyl chloride has a very high vapor pressure, 100 mm Hg at 25 °C(1), indicating that volatilization from soil will be rapid and a primary removal process. It has an estimated low adsorptivity to soil (Koc = 93-102)(1-2) and therefore would be mobile in soil. Biodegradation in soil is unknown(SRC).|AQUATIC FATE: If released in water, n-butyl chloride will be lost rapidly by volatilization. Its estimated volatilization half-life in a model river and pond are 2.9 hr(1-2) and 34 hr(3), respectively. In groundwater, where volatilization may not occur, n-butyl chloride may be lost by hydrolysis. Based upon hydrolysis rates for alkyl chlorides, the half-life is estimated to be between 6 hr and 38 days at neutral pH(4). The half-life at higher pHs will be shorter. Photodegradation, adsorption to sediment, and bioconcentration in fish are not important aquatic fate processes(SRC).|ATMOSPHERIC FATE: n-Butyl chloride will degrade via reaction with photochemically produced hydroxyl radicals in the atmosphere. The half-life of n-butyl chloride in the atmosphere is estimated to be 7.0 days(1). n-Butyl chloride does not absorb radiation >290 nm and therefore it will not directly photolyze(2). Due to its water solubility, 1100 mg/l(3), washout by rain should occur. However, n-butyl chloride removed in this manner will revolatilize into the atmosphere(SRC).|Maximum permissible concentrations in open waters are 0.004 mg/l.

Alkyl halides hydrolyze in water by neutral and base catalyzed reactions to give the corresponding alcohols; no acid catalyzed processes have been reported(2). No rate for neutral hydrolysis of n-butyl chloride is available. Based on extrapolations of hydrolysis rates of analogous compounds determined at higher temperatures and generalizations concerning the relative reactivity of analogs, the hydrolysis half-life of n-butyl chloride at 25 °C is estimated to lie in the range of 6 hr to 38 days(2). In the atmosphere, n-butyl chloride will react with photchemically produced hydroxyl radicals by H-atom extraction. The estimated rate of reaction is 2.29X10-12 cu cm/molec-sec(3). Assuming a hydroxyl radical concentration of 5X10+5 per cu cm, the half-life of n-butyl chloride in the atmosphere is 7.0 days. n-Butyl chloride does not absorb radiation >290 nm and therefore it will not directly photolyze(4). The half-life of n-butyl chloride in an eutrophic lake due to the photochemical production of hydroxyl radicals in full summer noon sunlight is 1000 hr(1). Therefore, this reaction would not be a significant degradation route for n-butyl chloride in surface waters(SRC).

16.98|Using the log octanol/water partition coefficient for n-butyl chloride, 2.64(1), one estimates a BCF of 60 using a recommended regression equation(2,SRC). Therefore, n-butyl chloride will not bioconcentrate in fish and aquatic organisms(2)

Using the water solubility for n-butyl chloride, 1100 mg/l(1), the Koc can be estimated to be 93 and 102 using two recommended regression equations(2,SRC). These estimates indicate that n-butyl chloride will have high mobility in soil(3).

Based on a Henry's Law constant of 0.0167 atm-cu m/mol(1), the volatilization of n-butyl chloride from a model river 1 m deep, flowing at 1 m/sec with a 3 m/sec wind is 2.9 hr(2). The volatilization half-life from a model pond is 34 hr(3). Due to its high vapor pressure and Henry's Law constant and low adsorptivity to soil, n-butyl chloride should volatilize rapidly from dry and moist soils(SRC).

Exposure to n-butyl chloride is primarily in the workplace. Probable routes occupational exposure are inhalation and dermal contact. (SRC)|NIOSH (NOES Survey 1981-1983) has statistically estimated that 3,201 workers are exposed to n-butyl chloride in the USA(1).

MEDICATION (VET): ANTHELMINTIC FOR TREATMENT OF ROUND- & TAPEWORMS IN DOGS ...|MEDICATION (VET): Anthelmintic

0.35 Days

Mildly irritating to the skin and eyes, liquid may cause rash due to removal of skin oils. Ingestion or skin absorbtion may cause intestinal upset, cramping, and central nervous system depression. (USCG, 1999)

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop. SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment. INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing. INGESTION: DO NOT INDUCE VOMITING. Volatile chemicals have a high risk of being aspirated into the victim's lungs during vomiting which increases the medical problems. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. IMMEDIATELY transport the victim to a hospital. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)

Fresh air, rest. Refer for medical attention.

Remove contaminated clothes. Rinse and then wash skin with water and soap.

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

TOXIC ON PROLONGED INHALATION.|WEAKER CENTRAL NERVOUS DEPRESSANT ACTIONS THAN ETHYL CHLORIDE.

1-chlorobutane

The substance can be absorbed into the body by inhalation of its vapour and by ingestion.

Cough. Sore throat. Drowsiness.

Redness. Dry skin.

Redness.

GRADES: NF; TECHNICAL.

All other basic organic chemical manufacturing|Butane, 1-chloro-: ACTIVE

The alternating current plasma detector for gas chromatography was shown to be a useful detector for selective organochlorine detection. A standard solution of n-butylchloride (NBC) was chromatographed at an oven temp of 85 °C and a calibration curve was constructed from the response data. The detection limit was determined to be 1.12 ng/sec and the correlation coefficient was 0.998.

Animal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients|Fire Hazards -> Flammable - 3rd degree