Tricalcium citrate
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Tricalcium citrate
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CAS No:
813-94-5
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Formula:
C6H8O7.3/2Ca
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Chemical Name:
Tricalcium citrate
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Synonyms:
1,2,3-Propanetricarboxylic acid,2-hydroxy-,calcium salt (2:3);Citric acid,calcium salt (2:3);Calcium citrate (Ca3(O7C6H5)2);Tricalcium citrate;Tribasic calcium citrate;Acicontral;Citrical;Tricalcium dicitrate;Citracal;12405-04-8
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CAS No:
Description
white powder or white to colourless crystals
Fine white powder
Calcium citrate is a salt typically used as a source of calcium in a variety of over the counter supplements.|A colorless crystalline or white powdery organic, tricarboxylic acid occurring in plants, especially citrus fruits, and used as a flavoring agent, as an antioxidant in foods, and as a sequestrating agent. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Tricalcium citrate Basic Attributes
498.43
497.894836
212-391-7
86117BWO7P
DTXSID7061148
A - Alimentary tract and metabolism
2918150000
Characteristics
281
-10.50520
white powder or white to colourless crystals
1.63 g/cm3
120ºC (loses water)
309.6ºC at 760 mmHg
155.2ºC
H2O: 0.1 M HCl: 0.01 M at 20 °C, clear, colorless
White powder /Tetrahydrate/
Safety Information
1
Stable. Incompatible with strong oxidizing agents.
SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.
Toxicity
Patients taking more than 4g of calcium a day are at risk of hypercalcemia and metabolic alkalosis. Chronic intake of calcium supplements is associated with adverse gastrointestinal symptoms such as constipation and flatulence.
About 46.4% of calcium is bound to plasma proteins.
Drug Information
For use as an over the counter calcium supplement.|FDA Label
Increases plasma calcium levels leading to a decrease in calcium flux and increase in calcium deposition into bone
Substances used in the processing or storage of foods or animal feed including ANTIOXIDANTS; FOOD PRESERVATIVES; FOOD COLORING AGENTS; FLAVORING AGENTS; ANTI-INFECTIVE AGENTS; EXCIPIENTS and other similarly used substances. Many of the same substances are used as PHARMACEUTIC AIDS. (See all compounds classified as Food Additives.)
The percentage of calcium absorbed varies inversely with intake. Tmax of about 3.5-5h varying with formulation.|Cleared via the kidneys but largely reabsorbed (98-99%) under normal conditions.
Calcium citrate increases plasma calcium levels. This reduces calcium flux from osteocyte activity by reducing the secretion of parathyroid hormone (PTH). Calcium does this by stimulating a G-protein coupled calcium receptor on the surface of parathyroid cells. The reduction in calcium flux increases the amount of calcium deposited in bone resulting in an increase in bone mineral density. The reduction in PTH secretion also reduces the amount of vitamin D metabolized to its active form, calcidiol. Since calcidiol increases the expression of calcium dependent ATPases and transient receptor potential cation channel subfamily V member 6 (TRPV6) both of which are involved in calcium uptake from the gut, a reduction in calcidiol results in less calcium absorption. Additionally, TRPV5, the channel responsible for calcium reabsorption in the kidney, is downregulated when PTH secretion is reduced thus increasing calcium excretion via the kidneys. Another hormone, calitonin, is likely involved in the reduction of bone resorption during periods of high plasma calcium.
Calcium Citrate
Tricalcium citrate Use and Manufacturing
... from citrus fruit: Cole, US patent 2,389,766 (1945 to California Fruit Growers Exchange). Review: Rudy, Pharmazie 4: 393 (1949).|A BY-PRODUCT IN THE MFR OF CITRIC ACID. /TETRAHYDRATE/
Calcium citrate is the calcium salt of citric acid. It is commonly used as a food additive (E333), usually as a preservative, but sometimes for flavor. In this sense, it is similar to sodium citrate. Calcium citrate is also found in some dietary calcium supplements (e.g. Citracal). Calcium makes up 24.1% of calcium citrate (anhydrous) and 21.1% of calcium citrate (tetrahydrate) by mass. The tetrahydrate occurs in nature as the mineral Earlandite.
Grades: reagent; technical; FCC. /Tetrahydrate/
1,2,3-Propanetricarboxylic acid, 2-hydroxy-, calcium salt (2:3): ACTIVE
EPA Safer Chemical Functional Use Classes -> Processing Aids and Additives|Safer Chemical Classes -> Green circle - The chemical has been verified to be of low concern|Food additives|Food Additives -> ACIDITY_REGULATOR; FIRMING_AGENT; SEQUESTRANT; -> JECFA Functional Classes|Cosmetics -> Buffering
Food Additives -> ACIDITY_REGULATOR; FIRMING_AGENT; SEQUESTRANT;
Computed Properties
Molecular Weight:498.4
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:14
Rotatable Bond Count:4
Exact Mass:497.8948275
Monoisotopic Mass:497.8948275
Topological Polar Surface Area:281
Heavy Atom Count:29
Complexity:211
Covalently-Bonded Unit Count:5
Compound Is Canonicalized:Yes
Drug Function and Efficacy
Not yet clear
Registered Holders
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ANMOL CHEMICALS PRIVATE LTD
Active
United States
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INDIA PHOSPHATE AND ALLIED INDUSTRIES PRIVATE LTD
Active
United States
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VASA PHARMACHEM PVT LTD
Active
United States
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