2-Hydroxy-1,2,3-propanetricarboxylic acid hydrate (1:1)
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2-Hydroxy-1,2,3-propanetricarboxylic acid hydrate (1:1)
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CAS No:
5949-29-1
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Formula:
C6H8O7.H2O
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Chemical Name:
2-Hydroxy-1,2,3-propanetricarboxylic acid hydrate (1:1)
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Synonyms:
1,2,3-Propanetricarboxylic acid,2-hydroxy-,hydrate (1:1);Citric acid,monohydrate;1,2,3-Propanetricarboxylic acid,2-hydroxy-,monohydrate;2-Hydroxy-1,2,3-propanetricarboxylic acid hydrate (1:1);2-Hydroxy-1,2,3-propanetricarboxylic acid monohydrate;Citronsyra Mono E 33-8-80MLT
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CAS No:
Description
white crystals or powder Citric acid monohydrate occurs as colorless or translucent crystals,or as a white crystalline, efflorescent powder. It is odorless and has astrong acidic taste. The crystal structure is orthorhombic.
SLIGHTLY DELIQUESCENT WHITE CRYSTALS.
Citric acid monohydrate is an organic molecular entity.|Citric Acid Monohydrate is a tricarboxylic acid found in citrus fruits. Citric acid is used as an excipient in pharmaceutical preparations due to its antioxidant properties. It maintains stability of active ingredients and is used as a preservative. It is also used as an acidulant to control pH and acts as an anticoagulant by chelating calcium in blood.|A key intermediate in metabolism. It is an acid compound found in citrus fruits. The salts of citric acid (citrates) can be used as anticoagulants due to their calcium chelating ability.
2-Hydroxy-1,2,3-propanetricarboxylic acid hydrate (1:1) Basic Attributes
210.13900
210.03800
611-842-9
2968PHW8QP
0704
DTXSID7074668
C47452
2918140000
Characteristics
141.36000
-1.3128
White crystals or powder
1.5 g/cm3
135 °C
56 °C760 mm Hg(lit.)
1 °F
n20/D 1.359(lit.)
H2O: 1630 g/L (20 ºC)
Citric acid monohydrate loses water of crystallization in dry air orwhen heated to about 408℃. It is slightly deliquescent in moist air.Dilute aqueous solutions of citric acid may ferment on standing.
184 mm Hg ( 20 °C)
2 (vs air)
LD50 orally in Rabbit: 3000 mg/kg
1010 °C
Dust explosion possible if in powder or granular form, mixed with air.
Safety Information
I; II; III
UN 1090 3/PG 2
1
R36/37/38; R41
S9-S16-S26-S37/39-S36/37/39
AL3150000
Xi
Separated from strong bases and oxidants.
Stable. Incompatible with oxidizing agents, bases, reducing agents, nitrates.
P305 + P351 + P338
H319
Combustible. Finely dispersed particles form explosive mixtures in air.
|Warning|H315 (20.51%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 1041 companies from 21 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P264, P280, P302+P352, P305+P351+P338, P321, P332+P313, P337+P313, and P362|Aggregated GHS information provided by 2 companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]|P264, P280, P305+P351+P338, and P337+P313|Aggregated GHS information provided by 2 companies from 1 notifications to the ECHA C&L Inventory.|H315: Causes skin irritation [Warning Skin corrosion/irritation]
Use water spray, foam, powder, carbon dioxide.
Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Wash away remainder with plenty of water.
Separated from strong bases and oxidants.
No indication can be given about the rate at which a harmful concentration of this substance in the air is reached on evaporation at 20 °C.
The aerosol is irritating to the eyes, skin and respiratory tract.
NO open flames. Closed system, dust explosion-proof electrical equipment and lighting. Prevent deposition of dust.
PREVENT DISPERSION OF DUST!
Use local exhaust or breathing protection.
Protective gloves.
Wear safety spectacles.
Drug Information
Agents that prevent BLOOD CLOTTING. (See all compounds classified as Anticoagulants.)|Substances that bind to and sequester CALCIUM ions. (See all compounds classified as Calcium Chelating Agents.)
Fresh air, rest.
Remove contaminated clothes. Rinse skin with plenty of water or shower.
First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Anhydrous Citric Acid
The substance can be absorbed into the body by inhalation of its aerosol and by ingestion.
Cough. Sore throat.
Redness.
Redness. Pain.
2-Hydroxy-1,2,3-propanetricarboxylic acid hydrate (1:1) Use and Manufacturing
1. Starch or sugar (such as sugar cane molasses) as raw material, relaction by fermentation. Potato powder disinfection and fermentation ↓ Aspergillus niger 26 ℃ Filtered mycelial washing Filtrate heating → lime precipitation → sulfuric acid neutralization → decolorization → resin exchange → crystallization → citric acid
2. First 12% ~ 16% potato taro powder sterilization, and then inoculated with Aspergillus pre-cultured mycelium, for fermentation. Adding ammonia water in the fermentation process, separating the hyphae from the fermentation liquor at 26℃ after 2 or 3 days, and adding the water after the mycelium washing to the fermentation liquor. And then heated to 90℃, the use of lime milk precipitation of citric acid, calcium citrate obtained with a little excess of sulfuric acid decomposition of citric acid, filtration, the filtrate with activated carbon decolorization, and then through the ion exchange resin to remove impurities, vacuum 60 ~ 70℃ concentrated, and cooled to not less than 36.6℃ conversion temperature, adding seeds, crystallization, cold air drying, after can get citric acid.
3 .Sugar solution as raw material, with the black yeast fermentation strains, separation, purification. Or extract from citric acid containing fruits, such as lemon juice (citric acid available 5% to 8%), pineapple waste directly.
4. Starchy raw materials such as potato stem, corn and other fermented by Aspergillus niger, and after separation, purification can be made pure.
5. This product is mainly produced by fermentation, the raw materials can be molasses, sucrose, sweet potatoes and petroleum hydrocarbons and other carbohydrates, the general use of fungi for fermentation production. Fermentation can be divided into surface fermentation and deep fermentation of two categories, the surface fermentation is the early production methods, with some of Penicillium or Aspergillus niger as a strain; deep fermentation of Aspergillus also Aspergillus species, the fermentation process In the formation of small spherical polymer aggregates should avoid the production of long and thin silk body, the fermentation conditions for the ph value of 1.5 to 2.8, while the need to pass through the sterile air and with agitation, after the completion of fermentation to remove filamentous bacteria and Residual solid waste, the filtrate calcium carbonate and calcium citrate, and then concentrated sulfuric acid and citric acid in the crude product, then ion exchange resin purification, concentration and crystallization to be finished.
A natural preservative and is also used to add an acidic, or sour, taste to foods and soft drinks. Citric acid monohydrate is mainly used in the food and beverage industries as a sour agent, flavoring agent, preservative, and preservative. It is also used as antioxidant, plasticizer, detergent in chemical industry, cosmetic industry and washing industry Mainly used as a sour agent for foods, and also for the preparation of medical cooling agents, additives for detergents, etc. Detect bismuth, nitrite, oxygen and water, determine aluminum, copper, mercury, nickel, oxygen and thorium, use it as a sequestrant, remove trace metals, prepare buffer solutions, and determine serum potassium.
EPA Safer Chemical Functional Use Classes -> Processing Aids and Additives|Safer Chemical Classes -> Green circle - The chemical has been verified to be of low concern|Human drugs -> Rare disease (orphan)
Computed Properties
Molecular Weight:210.14
Hydrogen Bond Donor Count:5
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:5
Exact Mass:210.03756727
Monoisotopic Mass:210.03756727
Topological Polar Surface Area:133
Heavy Atom Count:14
Complexity:227
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes
Price Analysis
- Data: 2026-07-29
- Price: 6012.50Yuan/mt
- Change: 0
Drug Function and Efficacy
Pharmacological action not specified
Registered Holders
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ANMOL CHEMICALS PRIVATE LTD
Active
United States
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Tianjin Yongkang Pharmaceutical Co., Ltd.
Active
China
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Sichuan Jinshan Pharmaceutical Co., Ltd.
Active
China
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2-Hydroxy-1,2,3-propanetricarboxylic acid hydrate (1:1)
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