Talc (Mg3H2(SiO3)4)

379.26600

377.81700

238-877-9

0329

DTXSID5032109

White to grayish-white, very fine crystalline powder|Apple-green powder; luster pearly or greasy; feel greasy|White powder.|A layered, hydrated magnesium silicate|Mono- or triclinic ... Pale-green to dark-green or greenish-gray; also white, silvery-white, grey, brownish; translucent; pearly, greasy or dull ... Commonly thin tabular crystals, up to 1 cm in width. Usually massive, fine-grained, compact; also as foliated or fibrous masses or in globular stellate groups

3802900090

197.00000

-2.89430

white to almost white micro fine powder

2.7-2.8 g/cm³

900-1000 °C

Index of refraction = 1.58

H2O: Insoluble

0 mmHg (approx)

Noncombustible Solid

Odorless.

Tasteless

Unctuous, and adheres readily to the skin.|Mohs hardness 1-1.5 (may be harder when impure)|Crystals of talc are made up of stacks of ... double-sheet units held together by the weakest of chemical bonds - the Van der Waal's forces. ... they can be separated by slight forces, causing slippage of the individual sheets along a perfect cleavage direction in the basal plane.|Relatively inert and nonreactive with conventional acids and bases. ... talc has Lewis acid sites on its surface and at elevated temperatures is a mild catalyst for oxidation, depolymerization, and cross-liking of polymers. ... Thermally stable up to 930 °C, and loses its crystalline bound water (4.8%) between 930 and 970 °C, leaving an enstatite (dehydrated magnesium silicate residue).|For more Other Experimental Properties (Complete) data for TALC (8 total), please visit the HSDB record page.

Insoluble in water.

Non-Redox-Active Inorganic Compounds

TALC has low reactivity.

Noncombustible Solid

R20

S36

WW2710000

Xn

Keep in a well-ventilated room. Well closed. Cool.

High resistance to acids, alkalies and heat.

P260, P264, P270, P307+P311, P314, P321, P405, P501

H370

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal, aquatic, and plant life; and conformance with environmental and public health regulations.|Landfill

The Approved Drug Products with Therapeutic Equivalence Evaluations List identifies currently marketed prescription drug products, incl talc, approved on the basis of safety and effectiveness by FDA under sections 505 of the Federal Food, Drug, and Cosmetic Act.|Certification of this color additive when used in amounts consistent with good manufacturing practice to color drugs generally is not necessary for the protection of the public health, and therefore batches thereof are exempt from the certification pursuant to section 721(c) of the act.|Substances migrating to food from cotton and cotton fabrics used in dry food packaging that are generally recognized as safe for their intended use, within the meaning of section 409 of the Act. Talc is included on this list.|Substances migrating to food from paper and paperboard products used in food packaging that are generally recognized as safe for their intended use, within the meaning of section 409 of the Act. Talc is included on this list.|Drug products containing certain active ingredients offered over-the-counter (OTC) for certain uses. A number of active ingredients have been present in OTC drug products for various uses, as described below. However, based on evidence currently available, there are inadequate data to establish general recognition of the safety and effectiveness of these ingredients for the specified uses: talc is included in astringent drug products.

KINGLAKE V; SOAP PERFUM COSMET 54 (AUG): 399 (1981). THE SOURCE OF TALC AND ITS USE IN THE FORMULATION OF BABY POWDERS, COSMETIC POWDERS, DRY SHAMPOOS, BLEACHING MASKS AND ANTIPERSPIRANTS ARE DISCUSSED.|DHHS/NTP; Toxicology & Carcinogenesis Studies of Talc in F344/N Rats and B6C3F1 Mice (Inhalation Studies) Technical Report Series No. 421 (1993) NIH Publication No. 93-3152|Merchant JA; Human Epidemiology: A review of Fiber Type and Characteristics in the Development of Malignant and Nonmalignant Disease. Environ Health Perspect 88: 287-93 (1990). Consideration of the human epidemiology of diseases arising from exposure to naturally occurring and man made mineral fibers encompasses the several forms of asbestos (chrysotile, crocidolite, amosite, anthophyllite, tremolite-actinolite), other naturally occurring silicates (talc, sepiolite, erionite, attapulgite, vermiculite, and wollastonite), and man made mineral fibers (glass continuous filament, glass/rock/slag insulation wools, ceramic and other refractory fibers, and glass microfibers).|Dutch Expert Committee for Occupational Standards; Health-based Recommended Occupational Exposure Limit for Talc Dusts. Ministerie van Sociale Zaken en Werkgelegenheid, Directoraat-Generaal van de Arbeid), Postbus 90804, 2509 LV Den Haag, Netherlands, 57. Talc is a hydrous magnesium silicate. Two different groups of talc dust must be distinguished: cosmetic grade talc and industrial grade talc.|Feigin DS; Misconceptions Regarding the Pathogenicity of Silicas and Silicates. J Thoracic Imaging 4 (1): 68-80 (1989). The pathogenicity of silicas and silicates was reviewed, with emphasis on talc. Particular attention was given to the controversies surrounding the results of inhalation of talc and other silicates, with an emphasis on exposures from nonmining settings. One controversy involved the definition of silicates and silicas. Particle shape and size have been important elements in these definitions. Distinctions between fibrous and nonfibrous silicates were not entirely clear.

Literature sources indicate that this chemical is nonflammable. (NTP, 1992)|Not combustible.

Not Classified| |Danger|H370: Causes damage to organs [Danger Specific target organ toxicity, single exposure]|P260, P264, P270, P307+P311, P314, P321, P405, and P501

Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992)|In case of fire in the surroundings, use appropriate extinguishing media.

SMALL SPILLS AND LEAKAGE: If you spill this chemical, you should dampen the solid spill material with water, then transfer the dampened material to a suitable container. Use absorbent paper dampened with water to pick up any remaining material. Seal your contaminated clothing and the absorbent paper in a vapor-tight plastic bag for eventual disposal. Wash all contaminated surfaces with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned. STORAGE PRECAUTIONS: You should store this material at ambient temperatures. (NTP, 1992)

Skin: No recommendation is made specifying the need for personal protective equipment for the body. Eyes: No recommendation is made specifying the need for eye protection. Wash skin: No recommendation is made specifying the need for washing the substance from the skin (either immediately or at the end of the work shift). Remove: No recommendation is made specifying the need for removing clothing that becomes wet or contaminated. Change: No recommendation is made specifying the need for the worker to change clothing after the work shift. (NIOSH, 2016)|Measures for health protection of workers exposed to talc dusts include... use of respiratory protective devices... .|Respirator Recommendations: Up to 10 mg/cu m: (Assigned protection factor = 5) Any dust and mist respirator. /Containing no asbestos and less than 1% quartz/|Respirator Recommendations: Up to 20 mg/cu m: (Assigned protection factor = 10) Any dust and mist respirator except single-use and quarter-mask respirators/(Assigned protection factor = 10) Any supplied-air respirator. /Containing no asbestos and less than 1% quartz/|Respirator Recommendations: Up to 50 mg/cu m: (Assigned protection factor = 25) Any powered, air-purifying respirator with a dust and mist filter/(Assigned protection factor = 25) Any supplied-air respirator operated in a continuous-flow mode. /Containing no asbestos and less than 1% quartz/|For more Personal Protective Equipment (PPE) (Complete) data for TALC (8 total), please visit the HSDB record page.|(See protection codes)

Ventilate area of spill. Collect spilled material in the most convenient and safe manner for reclamation or for disposal in a secured sanitary landfill.

SRP: Local exhaust ventilation should be applied wherever there is an incidence of point source emissions or dispersion of regulated contaminants in the work area. Ventilation control of the contaminant as close to its point of generation is both the most economical and safest method to minimize personnel exposure to airborne contaminants.|SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.|Measures for health protection of workers exposed to talc dusts include wetting in extractive processes, provision of adequate exhaust ventilation ... in milling and packing operations, supplemented by use of respiratory protective devices by workers and periodic medical exam ... including chest x-rays, pulmonary function tests ... and EKG ... .|There is little question but that the dust of nonfibrous talc, consisting almost entirely of platiform talc crystals and containing no asbestos, carries a relatively small respiratory hazard that must be controlled. The degree to which controls should be applied to talc dust should depend upon its asbestos content. /SRP: however, control may be indicated due to the OSHA nuisance dust standard./

Table Z-3 8-Hour Time Weighted Avg: 20 million particles per cubic feet of air (mppcf). /Talc (not containing asbestos) containing less than 1% quartz/

Recommended Exposure Limit: 10 Hr Time Weighted Avg: 2 mg/cu m (resp). /Containing no asbestos and less than 1% quartz/

Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Wash away remainder with plenty of water.

Keep in a well-ventilated room. Well closed. Cool.

A harmful concentration of airborne particles can be reached quickly.

May cause mechanical irritation to the eyes and respiratory tract.

The substance may have effects on the lungs. This may result in pneumoconiosis.

PREVENT DISPERSION OF DUST!

Use local exhaust or breathing protection.

Overalls. Protective gloves.

Wear safety spectacles.

Equal amount of talc mixed with benzo(a)pyrene administered to Syrian Golden hamsters produced papillomas, squamous cell carcinomas and undifferentiated tumors of larynx, trachea and lungs.|Chronic irritation reaction, fibrosis and granuloma formation were observed histologically after a single application of talc and zinc oxide on the wounded skin of rats.|Subcutaneous inflammation induced by magnesium silicate (talc) leads to the suppression of bone elongation, osteoblast insufficiency, and subsequent bone loss in rats. Since bone and immunological changes in talc granulomatosis are similar to those observed in zinc deficiency, the kinetics of zinc tissue distribution and the afects of zinc supplementation on the development of bone loss in rats with talc induced inflammation /were investigated/. Decrease in serum zinc concentration was observed between 5 and 15 hr in rats with talc granulomatosis. It was paralleled by the accumulation of zinc in the liver and rapid disappearance of osteoblasts from the trabecular bone surfaces. However, talc injected rats supplemented parenterally and orally with zinc sulfate exhibited a decrease in osteoblast trabecular surface comparable to that of unsupplemented rats bearing granulomas despite normalized serum zinc concentrations. Zinc supplementation slightly increased osteoblast trabecular surface in all supplemented groups, but this effect was not significant. It was concluded that zinc is the earliest indicator of the acute phase response in rats with talc granulomatosis. Although zinc appears to be important for the normal function of bone cells, there is no causative relationship between acute zinc deficiency and decreased osteoblast number and activity in rats with talc granulomatosis.|Single 20 mg ip injections of talc plus 2 mg of particulate prednisolone acetate in saline into mice induced significant numbers of multinucleated giant cells within 48 hours. Neither compound alone induced this response. The multinucleated cells arose by cell fusion, and the resultant polykarions exhibited severe chromosomal abnormalities. Prednisone in combination with talc also elicited the formation of multinucleated giant cells. Polykarions were not observed when talc was injected in combination with cortexone acetate, cortisone, or testosterone isobutyrate.

... Toxicology and carcinogenicity studies of talc (non-asbestiform, cosmetic grade), a finely powdered hydrous magnesium silicate, were conducted by exposing groups of F344/N rats to aerosols for 6 hr/day, 5 days/wk for up to 113 wk (males) or 122 wk (females). Groups of B6C3Fl mice were exposed similarly for up to 104 wk. LIFETIME STUDY IN RATS: Groups of 49 or 50 male and 50 female rats were exposed to aerosols of 0, 6, or 18 mg/cu m talc until mortality in any exposure group reached 80% (113 wk for males and 122 wk for females). ... These exposure concentrations provided a dose equivalent of 0, 2.8, or 8.4 mg/kg/day for male rats and 0, 3.2, or 9.6 mg/kg/day for female rats. ... The talc aerosols had a median mass aerodynamic diameter of 2.7 um in the 6 mg/cu m chamber and a median diameter of 3.2 um in the 18 mg/cu m chamber, with geometric standard deviations of 1.9 um. However, there was a 7 wk period beginning at study wk 11 during which the chamber concn for the 18 mg/cu m rats varied from approximately 30 to 40 mg/cu 3 because of difficulties with the aerosol concn monitoring system. Further, there was a 12 wk period beginning at approximately wk 70 during which there were difficulties in generating the talc aerosol, and the chamber concn for rats and mice were substantially lower than the target concn. 2-YEAR STUDY IN MICE: Groups of 47 to 49 male and 48 to 50 female mice were exposed to aerosols containing 0, 6, or 18 mg/cu m talc for up to 104 wk. ... These exposure concentrations provide a dose equivalent of 0, 2, or 6 mg/kg/day for male mice and 0, 1.3, or 3.9 mg/kg/day for female mice. ... The talc aerosols had a median mass aerodynamic diameter of 3.3 um with a geometric standard deviation of 1.9 um in the 6 mg/cu m. CONCLUSIONS: Under the conditions of these inhalation studies, there was some evidence of carcinogenic activity of talc in male F344/N rats based on an increased incidence of benign or malignant pheochromocytomas of the adrenal gland. There was clear evidence of carcinogenic activity of talc in female F344/N rats based on increased incidences of alveolar/bronchiolar adenomas and carcinomas of the lung and benign or malignant pheochromocytomas of the adrenal gland. There was no evidence of carcinogenic activity of talc in male or female B6C3F1 mice exposed to 6 or 18 mg/cu m.

NATIVE TALC, CALLED SOAPSTONE OR FRENCH CHALK, IS FOUND IN VARIOUS PARTS OF WORLD ... EXCELLENT QUALITY IS OBTAINED FROM NORTH CAROLINA ... MANCHUKUO (MANCHURIA). NATIVE TALC IS USUALLY ACCOMPANIED BY VARIABLE AMT OF OTHER MINERAL SUBSTANCES.|TALC IS A MINERAL PRODUCT, THE COMPOSITION OF WHICH VARIES WIDELY FROM ONE GEOLOGICAL DEPOSIT TO ANOTHER AND EVEN WITHIN THE SAME DEPOSIT. THE MAIN COMPONENT IS A CRYSTALLINE HYDRATED SILICATE OF MAGNESIUM.|The term talc ... covers a wide range of natural minerals, most of which are high magnesium silicates. It is a hydrous magnesium silicate, Mg3SiO10(OH)2, theoretically 31.7% MgO, 63.5% SiO2, and 4.8% H2O. The mineral talc is usually, although not always, a main constituent of mineral mixtures offered commercially as talc.|Minerals commonly associated with talc are tremolite (CaMg3(SiO3)4), serpentine (2MgO.2SiO2.2HsO), anthophyllite (Mg7.(OH)2.(Si4O11)2), magnesite, mica, and chlorite. The latter is a talclike mineral in which varying proportions of aluminium are substituted for magnesium in the brucite layer. Prochlorite, for example, is 9MgO.3Al2O3.5SiO2.8H2O|For more Natural Pollution Sources (Complete) data for TALC (6 total), please visit the HSDB record page.

... MIGRATES TO FOOD FROM PACKAGING MATERIALS.|Talc milling processes do not usually alter the mineral composition of the talc mixture delivered to the mill, but rather produce a talc with different physical properties dependent on particle size. Exposure to talc dust occurs during mining, crushing, separating, bagging, loading and in end-use facilities, such as rubber dusting and addition of talcs to ceramic clays and glazes. Since industrial talc is a misture of various associated minerals, occupational exposure is to a mixture of mineral dusts.|TO DATE ... NO REPORTS OF SIGNIFICANT RISK OF LUNG CANCER IN WORKERS EXPOSED TO ENOUGH TALC TO CAUSE PULMONARY FIBROSIS. IT MAY BE THAT SUCH NEOPLASTIC EFFECT HAS NOT BEEN NOTED BECAUSE NUMBER OF WORKERS EXPOSED TO ENOUGH TALC IS FAR SMALLER THAN NUMBER EXPOSED TO ASBESTOS.|POTENTIAL OCCUPATIONAL EXPOSURES INCL COSMETIC WORKERS, PAINT MAKERS, PAPER MAKERS, POTTERY MAKERS, RUBBER CABLE COATERS, RUBBER TIRE MAKERS, TALC MILLERS, TALC MINERS, & TALC POWDER MAKERS.|NIOSH (NOES Survey 1981-1983) has statistically estimated that 1,267,384 workers (348,973 of these are female) are potentially exposed to talc in the US(1). The NOES Survey does not include farm workers.

Talc intrapleural aerosol is indicated to prevent recurrence of malignant pleural effusions in symptomatic patients. It is administered during thoracoscopy or open thoracotomy.|...Talc insufflation, either as a poudrage or by using slurry, is recognized as an effective treatment /for spontaneous pneumothorax/.

...The case of a 78 yr-old man /is presented,/ who was treated with talc pleurodesis for recurrent pleural effusion and subsequently developed a massive hemothorax, a rare complication.|/The case of/ ...a young woman with a large, calcified anterior mediastinal mass discovered 18 months following a left talc pleurodesis /is reported/.

Agents that are put on the SKIN to reduce SWEATING or prevent excess sweating (HYPERHIDROSIS). (See all compounds classified as Antiperspirants.)

Foreign body granulomas containing talc fibers are to be found in lung, pleura, diaphragm, pericardium, and gastric wall ... .|...Transmission electron microscopy and energy dispersive X-ray spectroscopy /was used to analyze/ the total fibrous and nonfibrous mineral content of the lungs of a series of 14 male smokers with lung cancer but with no history of occupational dust exposure, and of a series of 14 control men matched by age, smoking history and general occupational class. The average concentration of mineral fibers and nonfiberous particles were 3.8 and 2.0 times higher in the group with cancer. Kaolinite, talc, mica, feldspars and crystalline silica comprised the majority of fibrous and nonfibrous particles in both groups.|Mice that received a sterile sc injection of talc were studied by measuring the incorporation of radioactive leucine and glucosamine into liver and plasma protein and the talc gramuloma at various intervals between 2 and 528 hours after injection. Incorporation into plasma proteins indicated a biphasic response with a marked increased incorporation into the perchloric acid insoluble fraction at 21 hours, a return to normal values at 45 hours, and a similar marked increase into the perchloric acid soluble fraction at 45 hours with a gradual return toward normal values. The response was dependent upon the amount of talc injected.|Using radioactive tracer techniques in rats, mice, guinea pigs, and hamsters, no intestinal absorption or translocation of ingested talc to the liver and kidneys was detected.|For more Absorption, Distribution and Excretion (Complete) data for TALC (7 total), please visit the HSDB record page.

In hamsters, ...the biological half-life of talc deposited in the alveoli was 7-10 days, and the alveolar clearance was basically complete 4 months after exposure.

Impurities: dolomite; calcite; iron oxide; carbon; quartz; and manganese oxide|Tremolite|Commercial talc often contains other mineral contaminants including crystalline silica as well as amphibole and serpentine forms of asbestos... The upstate New York mines are contaminated with tremolite and anthophyllite. Vermont ... mining ore deposits /are/ without significant asbestos and crystalline silica contamination

Exposure Routes: inhalation, skin and/or eye contact Symptoms: Fibrotic pneumoconiosis; irritation eyes Target Organs: Eyes, respiratory system, cardiovascular system (NIOSH, 2016)|Carcinogens

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop. SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment. INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing. INGESTION: DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)|(See procedures)

Fresh air, rest.

Rinse and then wash skin with water and soap.

Rinse with plenty of water (remove contact lenses if easily possible).

Basic treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if needed. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool ... . Cover skin burns with dry sterile dressings after decontamination ... . /Poison A and B/|Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in respiratory arrest. Positive pressure ventilation techniques with a bag valve mask device may be beneficial. Monitor cardiac rhythm and treat arrhythmias as necessary ... . Start an IV with D5W /SRP: "To keep open", minimal flow rate/. Use lactated Ringer's if signs of hypovolemia are present. Watch for signs of fluid overload. Consider drug therapy for pulmonary edema ... . For hypotension with signs of hypovolemia, administer fluid cautiously. Watch for signs of fluid overload ... . Treat seizures with diazepam (Valium) ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Poison A and B/

/EPIDEMIOLOGY STUDIES/ Capsular contracture, constrictive tightening of scar tissue around implants, was historically the primary reason for reoperating breast-implanted women. ...A comparison of 192 explanted women was designed to investigate the role of talc in the induction of capsular contracture. ...Patients were evaluated for the occurrence of capsular contracture and the presence of intracellular talc particles in peri-implant tissues. There was a significant association between talc and capsular contracture (odds ratio =18.0, 95% confidence interval = 5.9-55, P<1 x 10-9).|/HUMAN EXPOSURE STUDIES/ 66 individuals ... had been exposed to dust in 2 mills and mines handling Georgia steatite talc (soapstone) with 10% tremolite content; they found no pneumoconiosis in those who worked at average dust concentration of 17 million parts/cu ft, but severe and disabling cases were ... in groups working at average dust concentrations of 135-300 mppcf. /Georgia steatite talc/|/OTHER TOXICITY INFORMATION/ Although talc is benign substance when applied to intact skin, it can induce severe granulomatous reactions when introduced into wounds or operative field.|/CASE REPORTS/ Cases... arise after many years of exposure to talc used in cable and rubber manufacturing. Through an indolent course, steadily progressing to terminal bouts of respiratory and/or cardiac failure. Talc bodies- very like asbestos bodies- may be found in sputum as evidence of exposure.|For more Human Toxicity Excerpts (Complete) data for TALC (40 total), please visit the HSDB record page.

Talc

Exposure mainly occurs via inhalation.|inhalation, skin and/or eye contact

Fibrotic pneumoconiosis, irritation eyes

Cough.

No acute symptoms expected.

Redness. Pain.

Eyes, respiratory system, cardiovascular system

(Including soapstone and pyrophyllite): 20% as additive in ceramic manufacture; 15% as filler or pigment for paints; 7% as additive in paper coatings; 5% as carrier or diluent for insecticides; 4% as additive for roofing materials; 3% as additive for toilet preparations; 2% as filler for elastomers; and 44% for other uses in plastics, stucco, floor tile, foundry facings, rice polishing, crayons, art sculpture, refractories, asphalt, textiles, bricks, enamel coating, fertilizer, insulated wire and cable, joint cement (1975)|Ceramics, 37%; Paints, 19%; Paper, 10%; Roofing, 9%; Plastics, 7%; Cosmetics, 5%; Rubber, 3%; insecticides, 1%; & other, 9% (1985)|Domestically produced ground talc was used in paint, 32%; ceramics, 28%; paper, 18%; roofing, 6%; plastics, 6%; rubber, 4%; cosmetics, 3%; and other, 3%.

Grades: crude; washed; air-floated; USP; fibrous (99.5%, 99.95%).|Talc, when it is isolated as a pure mineral, has a composition of 63.6% SiO2, 21.89% MgO, and 4.75% H2O. However, as an industrial commodity, talc rarely approaches theoretical purity.|When the ultra fine grinds are used (Mistron grades), they contribute to large surface areas, are non-reactive with sensitive toxicants and can be used in wettable powders.

Adhesive manufacturing|Talc (Mg3H2(SiO3)4): ACTIVE|Natural hydrous magnesium silicate. Compact, massive varieties may be called steatite in distinction from the foliated varieties, which are called talc. Soapstone is an impure variety of steatite.|Talc is nonadsorbent to materials in solution and is chemically inert medium for filtering any liquid, provided it has been purified for this purpose and it is not impalpably fine variety which will pass through filter paper.|Slowly disappearing as popular powder vehicle for major wound therapeutic ingredients.|Talc should never be used as dusting powder for surgical gloves.|For more General Manufacturing Information (Complete) data for TALC (10 total), please visit the HSDB record page.

SEVERAL BATCHES OF TALC FROM DIFFERENT GEOGRAPHICAL REGIONS WERE ANALYZED BY ATOMIC ABSORPTION SPECTROSCOPY AND THE ACID-SOLUBLE AND ACID-INSOLUBLE CATION CONTENT DETERMINED.|Talc determination by IR spectrography.

Health Hazards -> Carcinogens|Cosmetics -> Absorbent; Bulking

Food Additives -> ANTICAKING_AGENT; BULKING_AGENT; CHEWING_GUM_BASE_COMPOUND; FILTERING_AID; GLAZING_AGENT; THICKENER;