Dibutyltin diacetate

351.01800

351.03

213-928-8|241-521-5

BC9AZH1UZG

8786

2788

DTXSID3020419

COLORLESS LIQUID|Clear, yellow liquid

29310095

52.60000

3.15500

clear yellow liquid.

1.31 g/cm³ @ Temp: 25 °C

10 °C

130 °C @ Press: 2 Torr

143ºC

n20/D 1.471(lit.)

H2O: insoluble

Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Do not store

1.3 mm Hg ( 25 °C)

12 (vs air)

Slight acetic acid

Freezing point 5-10 °C

Forms white precipitate in water. Insoluble in water.

Salts, Basic

DIBUTYLTIN DIACETATE is stable under normal laboratory conditions. This compound may react with oxidizers. (NTP, 1992). Strongly reactive with many other groups. Incompatible with acids and bases. Organometallics are good reducing agents and therefore incompatible with oxidizing agents.

II

6.1

UN 2922 8/PG 2

3

R25; R36/38

S26-S28-S37/39-S45

WH6880000

T

Stable at room temperature in closed containers under normal storage and handling conditions.

P201-P260-P273-P280-P305 + P351 + P338-P310

H314-H317-H341-H360-H370-H372-H410

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

This chemical is combustible. (NTP, 1992)

|Danger|H300 (12.34%): Fatal if swallowed [Danger Acute toxicity, oral]|P201, P202, P260, P261, P264, P270, P272, P273, P280, P281, P301+P310, P301+P330+P331, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P307+P311, P308+P313, P310, P314, P321, P330, P333+P313, P363, P391, P405, and P501|Aggregated GHS information provided by 627 companies from 37 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|H300: Fatal if swallowed [Danger Acute toxicity, oral]|P201, P202, P260, P264, P270, P273, P281, P301+P310, P308+P313, P314, P321, P330, P391, P405, and P501

Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]: As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids. SPILL: Increase, in the downwind direction, as necessary, the isolation distance shown above. FIRE: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2016)

SMALL SPILLS AND LEAKAGE: If you spill this chemical, use absorbent paper to pick up all liquid spill material. Your contaminated clothing and absorbent paper should be sealed in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with alcohol followed by washing with a strong soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned. STORAGE PRECAUTIONS: You should store this material in a refrigerator. (NTP, 1992)

MINIMUM PROTECTIVE CLOTHING: If Tyvek-type disposable protective clothing is not worn during handling of this chemical, wear disposable Tyvek-type sleeves taped to your gloves. RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter. (NTP, 1992)|Employees should be provided with & required to use impervious clothing, gloves, face shields (8 inch minimum), & other appropriate protective clothing necessary to prevent repeated or prolonged skin contact with ... solid or liquid dibutyltin diacetate. ... Employees should be provided with & required to use dust- & splash-proof safety goggles where solid or liquid dibutyltin diacetate ... may contact the eyes.

Combustible when exposed to heat or flame; can react with oxidizing materials.

To fight fire use water, foam, carbon dioxide, dry chemical.

Clothing contaminated with ... dibutyltin diacetate ... should be placed in closed containers for storage until it can be discarded or until provision is made for the removal of contaminant from the clothing. If the clothing is to be laundered or otherwise cleaned to remove the contaminant, the person performing the operation should be informed of contaminant's hazard properties. ... Non-impervious clothing which becomes contaminated with ... dibutyltin diacetate ... should be removed promptly & not reworn until the contaminant is removed.|Skin that becomes contaminated with ... dibutyltin diacetate ... should be promptly washed or showered with soap or mild detergent & water to remove any contaminant. ... Eating & smoking should not be permitted in areas where ... dibutyltin diacetate ... is handled, processed, or stored.

LD50 Rat oral 32 mg/kg|LD50 Mouse oral 46 mg/kg|LD50 Mouse intravenous 18 mg/kg|LD50 MOUSE ORAL 109.7 MG/KG

A bioassay for the possible carcinogenicity of dibutyltin diacetate was conducted using Fischer 344 rats and B6C3F1 mice. Dibutyltin diacetate was admin in the feed, at either of two concn, to groups of 50 male and 50 female animals of each species. Twenty animals of each sex and species were placed on test as controls. The high and low time weighted avg dietary concn of dibutyltin diacetate were, respectively, 133 and 66.5 ppm for rats and 152 and 76 ppm for mice. The cmpd was admin for 78 wk to rats and mice, followed by a period of no cmpd admin of 26 wk for rats and 14 wk for mice. ... Under the conditions of this bioassay, there was no ... evidence of carcinogenicity for dibutyltin diacetate in male Fischer 344 rats or B6C3F1 mice of either sex. The loss of tissues taken from high dose female rats /reduced the sensitivity in this/ bioassay ... for female Fischer 344 rats. Levels of Evidence of Carcinogenicity: Male Rats: Negative; Female Rats: Inadequate Study; Male Mice: Negative; Female Mice: Negative.

DIBUTYLTIN DIACETATE UNDERGOES MONOOXYGENASE OR NONENZYMATIC CLEAVAGE TO BUTYLTIN DERIVATIVES. SEVERAL OF METABOLITES FORMED IN MICROSOMAL MONOOXYGENASE SYSTEM ARE DETECTED IN LIVER & FECES OF MICE ORALLY ADMIN DIBUTYLTIN DIACETATE.|Dibutyltin diacetate yielded butyltin derivatives under the reaction conditions used. Several of the metabolites that were produced in vitro were also found in the liver or feces of mice exposed to tributyltin acetate or dibutyltin diacetate by gavage. In the isolated rat liver microsome system, other trialkyltin compounds, including the ethyl, propyl, pentyl, hexyl and cyclohexyl derivatives, appeared to undergo analogous monooxygenase reactions.

... IT IS EXTREMELY DIFFICULT TO PREPARE DIALKYLTIN COMPOUNDS AS PURE COMPOUNDS, THERE GENERALLY BEING PRESENT TRACES OF THE CORRESPONDING TRIALKYL DERIVATIVES. /DIALKYLTIN COMPOUNDS/

SYMPTOMS: This compound may cause skin rashes after contact. ACUTE/CHRONIC HAZARDS: This compound can be absorbed through the skin and can cause skin rashes following contact. (NTP, 1992)

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop. SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. IMMEDIATELY call a hospital or poison control center even if no symptoms (such as redness or irritation) develop. IMMEDIATELY transport the victim to a hospital for treatment after washing the affected areas. INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. IMMEDIATELY call a physician and be prepared to transport the victim to a hospital even if no symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing. INGESTION: Some heavy metals are VERY TOXIC POISONS, especially if their salts are very soluble in water (e.g., lead, chromium, mercury, bismuth, osmium, and arsenic). IMMEDIATELY call a hospital or poison control center and locate activated charcoal, egg whites, or milk in case the medical advisor recommends administering one of them. Also locate Ipecac syrup or a glass of salt water in case the medical advisor recommends inducing vomiting. Usually, this is NOT RECOMMENDED outside of a physician's care. If advice from a physician is not readily available and the victim is conscious and not convulsing, give the victim a glass of activated charcoal slurry in water or, if this is not available, a glass of milk, or beaten egg whites and IMMEDIATELY transport victim to a hospital. If the victim is convulsing or unconscious, do not give anything by mouth, assure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)

dibutyltin diacetate

The use of organotin compounds to stabilize polymers and copolymers of vinyl chloride results from research performed in the 1930s. However, it was not until 1946 that organotins were made generally available. For approximately the next 7 years, the family of compounds proliferated rapidly and were used in all type of vinyl processing situations. In the early 1950s, mixed-metal stabilizer combinations displaced organotins in almost all processing operations employing plasticized vinyl compounds. Mixed-metal stabilizer combinations have not been able to compete successfully with organotin mercaptides in applications involving unplasticized polyvinyl chloride.

Adhesive manufacturing|Acetic acid, 1,1'-(dibutylstannylene) ester: ACTIVE|Organotin stabilizers are all derivatives of tetravalent tin. ... The organic groups bonded to tin are either alkyl or, substituted alkyl. Aryltin compounds have been shown to be poor stabilizers for polyvinyl chloride. /Organotin cmpd/|With regard to heat stabilizing efficacy, it is generally accepted that the dialkyltin compounds containing 2 anionic substituents are better than either the monoalkyl- or trialkyltin derivatives. /Dialkyltin compounds/