Glycyrrhizic acid ammonium salt
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Glycyrrhizic acid ammonium salt
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CAS No:
53956-04-0
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Formula:
C42H65NO16
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Chemical Name:
Glycyrrhizic acid ammonium salt
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Synonyms:
monoammoniumglycyrrhetat;Monoammoniumglycyrrhetate;monoammoniumglycyrrhizate;(2S,3S,4S,5R,6S)-6-[[(3S,4aS,6aR,6bS,8aR,11S,12aR,14aS,14bS)-11-carboxy-4,4,6a,6b,8a,11,14b-heptamethyl-14-oxo-2,3,4a,5,6,7,8,9,10,12,12a,14a-dodecahydro-1H-picen-3-yl]oxy]-5-[(2R,3R,4S,5S,6S)-6-carboxy-3,4,5-trihydroxy-oxan-2-yl]oxy-3,4-dihydroxyoxane-2-carboxylic acid azane;alpha-D-Glucopyranosiduronic acid, (3-beta,20-beta)-20-carboxy-11-oxo-30-norolean-12-en- 3-yl 2-O-beta-D-glucopyranuronosyl-, ammoniate;20β-Carboxy-11-oxo-30-noroleana-12-ene-3β-yl 2-O-(β-D-glucopyranuronosyl)-α-D-glucopyranosiduronic acid/ammonia,(1:x);Glycyrrhizine ammonium salt;AMMONIUM 10-[6-CARBOXY-3-(6-CARBOXY-3,4,5-TRIHYDROXY-OXAN-2-YL)OXY-4,5-DIHYDROXY-OXAN-2-YL]OXY-2,4A,6A,6B,9,9,12A-HEPTAMETHYL-13-OXO-3,4,5,6,6A,7,8,8A,10,11,12,14B-DODECAHYDRO-1H-PICENE-2-CARBOXYLATE
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CAS No:
Description
Monoammonium glycyrrhizinate hydrate has various pharmacological actions such as anti-inflammatory, antiallergic, antigastriculcer, and antihepatitis activities.
§ 184.1408(a)(1) Licorice (glycyrrhiza) root is the dried and ground rhizome and root portions of Glycyrrhiza glabra or other species of glycyrrhiza. Licorice extract is that portion of the licorice root that is, after maceration, extracted by boiling water. The extract can be further purified by filtration and by treatment with acids and ethyl alcohol. Licorice extract is sold as a liquid paste ("block"), or spraydried powder. (2) Ammoniated glycyrrhizin is prepared from the water extract of licorice root by acid precipitation followed by neutralization with dilute ammonia. Monoammonium glycyrrhizinate (C42H61016NH45H2O ) is prepared from ammoniated glycyrrhizin by solvent extraction and separation techniques.
white to slightly yellow powder
ChEBI: Monoammonium glycyrrhizinate is an organic molecular entity.
Produced and qualified by HWI pharma services GmbH.Exact content by quantitative NMR can be found on the certificate.
Glycyrrhizic acid ammonium salt Basic Attributes
839.97
839.43033499 g/mol
3897076
258-887-7
TSCA listed
DTXSID2041204
Yellow to yellow-green
29389090
Characteristics
272.70000
0.32860
Yellow to yellow-green Powder or Crystals
1.1846 (rough estimate)
>200°C (dec.)
768.56°C (rough estimate)
288.1ºC
49 ° (C=1.5, EtOH)
2-8°C
bland
2-8°C
Safety Information
UN 3077 9 / PGIII
2
LZ6500000
Stable under normal temperatures and pressures.
UN 3077 9 / PGIII
|Warning|H302 (18.18%): Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P280, P301+P312, P305+P351+P338, P330, P337+P313, and P501|Aggregated GHS information provided by 108 companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Glycyrrhizic acid ammonium salt Use and Manufacturing
pharmaceutical excipient, GRAS, sweetener
Ammonium Glycyrrhizinate is used in the synthesis of polyion complex nanocarriers which may act as a template for the design of other negatively charged water-soluble drugs. Particularly for anti-infl ammatory drugs with which Ammonium Glycyrrhizinate is associated.
anti-cancer agent
Glycyrrhizic acid ammonium salt is a flavoring and sweetening agent obtained from licorice flavonoids. It has a slight licorice flavor and an intense and rounded sweetness. It is soluble in water, glycerin, and propylene glycol and has good thermal stability but can degrade under prolonged heating. It is stable over a ph of 3.5–9 but could precipitate below ph of 3.5. It can be used in beverages, desserts, confectionary products, soups, and dressings.
.alpha.-D-Glucopyranosiduronic acid, (3.beta.,20.beta.)-20-carboxy-11-oxo-30-norolean-12-en-3-yl 2-O-.beta.-D-glucopyranuronosyl-, ammonium salt (1:1): ACTIVE
Food additives -> Flavoring Agents|Cosmetics -> Skin conditioning
Flavoring Agents
Computed Properties
Molecular Weight:894.0
Hydrogen Bond Donor Count:12
Hydrogen Bond Acceptor Count:20
Rotatable Bond Count:7
Exact Mass:893.46202903
Monoisotopic Mass:893.46202903
Topological Polar Surface Area:271
Heavy Atom Count:62
Complexity:1730
Defined Atom Stereocenter Count:19
Covalently-Bonded Unit Count:5
Compound Is Canonicalized:Yes
Drug Function and Efficacy
It has a strong affinity for steroid metabolic enzymes in the liver, thereby hindering the inactivation of cortisol and aldosterone, showing obvious corticosteroid-like effects, such as anti-inflammatory, anti-allergic and protective membrane structure; promoting monochromatic metabolism, reducing the release of ALT and AST; inducing γ-IFN and interleukin II, increasing NK cell activity and OKT4/OKT8 ratio and activating the reticuloendothelial system; inhibiting the release of histamine from mast cells; inhibiting the formation of cell membrane phospholipase A2 (PL-A2) and prostaglandin E2 (PGE2) and granulomatous reactions; inhibiting the production and formation of free radicals and lipid peroxides, reducing the activity of proline hydroxylase; regulating calcium ion channels, protecting lysosomal membranes and mitochondria
Registered Holders
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Qingdao Keyuan Huigu Biopharmaceutical Co., Ltd.
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China
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XinjiangTianshan Pharmaceutical Ind. Co., Ltd.
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China
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Qingdao TAI TONG Pharmaceutical Co., Ltd.
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China
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