Ammonium glycyrrhizinate
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Ammonium glycyrrhizinate
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CAS No:
53956-04-0
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Formula:
C42H62O16.H3N
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Chemical Name:
Ammonium glycyrrhizinate
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Synonyms:
α-D-Glucopyranosiduronic acid,(3β,20β)-20-carboxy-11-oxo-30-norolean-12-en-3-yl 2-O-β-D-glucopyranuronosyl-,ammonium salt (1:1);α-D-Glucopyranosiduronic acid,(3β,20β)-20-carboxy-11-oxo-30-norolean-12-en-3-yl 2-O-β-D-glucopyranuronosyl-,monoammonium salt;30-Noroleanane,α-D-glucopyranosiduronic acid deriv.;Ammonium glycyrrhizinate;Glycyrrhizic acid ammonium salt;Glycyrrhizin ammonium salt;Monoammonium glycyrrhizinate;Glycyrram;Glycamil;18β-Glycyrrhizic acid monoammonium salt;Monoammonium glycyrrhizate;Glycyrrhizin monoammonium salt;Ammonium glycyrrhizate;Glycyrrhizic acid monoammonium salt;Glycymin;NSC 2800;NSC 35348;Magnasweet;(+)-Glycyram;Monoammonium 18β-glycyrrhizinate;Glycyron ammonium salt;Glycyron monoammonium salt;97635-37-5;1407-03-0;42618-06-4;52248-53-0;202522-36-9;1208112-20-2
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CAS No:
Description
Monoammonium glycyrrhizinate hydrate has various pharmacological actions such as anti-inflammatory, antiallergic, antigastriculcer, and antihepatitis activities.
Ammonium glycyrrhizinate Basic Attributes
839.96
839.43033499 g/mol
258-887-7
DTXSID2041204
29389090
Characteristics
272.70000
0.32860
Yellow to yellow-green Powder or Crystals
1.43g/cm3
>200°C(dec.)
996.6°C at 760 mmHg
288.1ºC
49 ° (C=1.5, EtOH)
2-8°C
Safety Information
UN 3077 9 / PGIII
2
LZ6500000
Stable under normal temperatures and pressures.
|Warning|H302 (18.18%): Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P280, P301+P312, P305+P351+P338, P330, P337+P313, and P501|Aggregated GHS information provided by 108 companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Ammonium glycyrrhizinate Use and Manufacturing
pharmaceutical excipient, GRAS, sweetener
.alpha.-D-Glucopyranosiduronic acid, (3.beta.,20.beta.)-20-carboxy-11-oxo-30-norolean-12-en-3-yl 2-O-.beta.-D-glucopyranuronosyl-, ammonium salt (1:1): ACTIVE
Food additives -> Flavoring Agents|Cosmetics -> Skin conditioning
Flavoring Agents
Computed Properties
Molecular Weight:894.0
Hydrogen Bond Donor Count:12
Hydrogen Bond Acceptor Count:20
Rotatable Bond Count:7
Exact Mass:893.46202903
Monoisotopic Mass:893.46202903
Topological Polar Surface Area:271
Heavy Atom Count:62
Complexity:1730
Defined Atom Stereocenter Count:19
Covalently-Bonded Unit Count:5
Compound Is Canonicalized:Yes
Drug Function and Efficacy
It has a strong affinity for steroid metabolic enzymes in the liver, thereby hindering the inactivation of cortisol and aldosterone, showing obvious corticosteroid-like effects, such as anti-inflammatory, anti-allergic and protective membrane structure; promoting monochromatic metabolism, reducing the release of ALT and AST; inducing γ-IFN and interleukin II, increasing NK cell activity and OKT4/OKT8 ratio and activating the reticuloendothelial system; inhibiting the release of histamine from mast cells; inhibiting the formation of cell membrane phospholipase A2 (PL-A2) and prostaglandin E2 (PGE2) and granulomatous reactions; inhibiting the production and formation of free radicals and lipid peroxides, reducing the activity of proline hydroxylase; regulating calcium ion channels, protecting lysosomal membranes and mitochondria
Registered Holders
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Qingdao Keyuan Huigu Biopharmaceutical Co., Ltd.
Active
China
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XinjiangTianshan Pharmaceutical Ind. Co., Ltd.
Active
China
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Qinghai Lake Pharmaceutical Co., Ltd.
Active
China
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