Silymarin
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Silymarin
structure -
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CAS No:
65666-07-1
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Chemical Name:
Silymarin
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Synonyms:
Silymarin;Legalon 70;Legalon;Flavobion;Pluropon;Silirex;Silmar;Silarin;Apihepar;Silymarin Group;Silepar;Laragon;Karsilin;Silistrong;Silystrong;Darsil;Silybon
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CAS No:
Description
Silymarin is an extract of the milk thistle (Silybum marianum). Silymarin can significantly reduce tumor cell proliferation, angiogenesis as well as insulin resistance. Silymarin has the chemopreventive effect on hepatocellular carcinoma (HCC)[1].
Milk thistle is an annual or biennial herb native to the Mediterranean region, which has been used for centuries as a food and as a medicinal herb for treatment of liver conditions. Milk thistle has not been implicated in causing liver injury and is still used widely as a liver tonic in patients with acute and chronic liver diseases.|Milk Thistle is a substance derived from any of several Old World coarse prickly-leaved shrubs and subshrubs including the plant Silybum marianum. Milk thistle's active chemical component is silymarin, which is a combination of flavonoids such as silibinin, dehydrosilibinin, silychristin and silydianin. These compounds are antioxidants and may alter the membrane structure of the liver cell, thereby blocking the absorption of toxins; they may also stimulate the production of new liver cells. In addition, milk thistle may increase cellular adenosine triphosphate (ATP) levels, exhibiting dose-dependent cardiac myocyte cytoprotection against doxorubicin. The silibinin component of milk thistle has been shown to inhibit growth factor receptor-mediated mitogenic and cell survival signaling, thereby inhibiting tumor growth. (NCI04)|The major active component of silymarin flavonoids extracted from seeds of the MILK THISTLE, Silybum marianum; it is used in the treatment of HEPATITIS; LIVER CIRRHOSIS; and CHEMICAL AND DRUG INDUCED LIVER INJURY, and has antineoplastic activity; silybins A and B are diastereomers.
Silymarin Basic Attributes
48244
482.121307
613-830-9
853OHH1429
DTXSID5023580|DTXSID30858697|DTXSID5031971
C29261
A - Alimentary tract and metabolism
3003909090
Characteristics
155.14000
2.59
Yellow and brown powder
1.5±0.1 g/cm3
158 °C
793.0±60.0 °C at 760 mmHg
274.5±26.4 °C
1.684
−20°C
Safety Information
3
22-24/25
|Warning|H361 (100%): Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]|P201, P202, P260, P281, P308+P313, P314, P405, and P501|Aggregated GHS information provided by 2 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Toxicity
Despite its wide spread use in patients with and without liver disease, milk thistle has not been implicated in causing serum enzyme elevations or clinically apparent acute liver injury. While silymarin has effects on cytochrome P450 enzymes and hepatic transporters in vitro, there is little evidence that it causes clinically significant herb-drug interactions.
Drug Information
Milk thistle is an annual or biennial herb native to the Mediterranean region, which has been used for centuries as a food and as a medicinal herb for treatment of liver conditions. Milk thistle has not been implicated in causing liver injury and is still used widely as a liver tonic in patients with acute and chronic liver diseases.
Herbal and Dietary Supplements
Agents obtained from higher plants that have demonstrable cytostatic or antineoplastic activity. (See all compounds classified as Antineoplastic Agents, Phytogenic.)|Synthetic or natural substances which are given to prevent a disease or disorder or are used in the process of treating a disease or injury due to a poisonous agent. (See all compounds classified as Protective Agents.)
2,3 Dehydrosilybin
Computed Properties
Molecular Weight:482.4
XLogP3:2.4
Hydrogen Bond Donor Count:5
Hydrogen Bond Acceptor Count:10
Rotatable Bond Count:4
Exact Mass:482.12129689
Monoisotopic Mass:482.12129689
Topological Polar Surface Area:155
Heavy Atom Count:35
Complexity:750
Defined Atom Stereocenter Count:4
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
Drug Function and Efficacy
It has antitoxic effects on muscimol, α-amanitin, carbon tetrachloride, galactosamine, thioacetamide and hepatovirus FV3
Registered Holders
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Guangshengtang Zhongxing (Jiangsu) Pharmaceutical Co., Ltd.
Active
China
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Beijing Jingfeng Pharmaceutical (Shandong) Co., Ltd.
Active
China
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Liverd PHARMA Co., Ltd.
Active
China
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