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Omeprazole sodium

Omeprazole sodium structure

CAS No:
95510-70-6
Formula:
C17H19N3O3S.Na
Chemical Name:
Omeprazole sodium
Synonyms:
1H-Benzimidazole,6-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-,sodium salt (1:1);1H-Benzimidazole,5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-,sodium salt;Omeprazole sodium;Omeprazole sodium salt;H 168/68 sodium;Losec Sodium;(±)-Omeprazole sodium salt;5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole sodium salt;5-Methoxy-2-[[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl]-1H-benzimidazole sodium salt;142706-19-2;226903-65-7
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

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Description

White or almost white, hygroscopic powder.

The S-isomer of omeprazole.

Omeprazole sodium Basic Attributes

Molecular Weight：

368.41

Exact Mass：

385.107208

HScode：

2933990090

Characteristics

PSA：

94.68000

XLogP3：

3.48690

Appearance：

Clear in water

Density：

1.37g/cm3

Boiling Point：

600ºC at 760mmHg

Flash Point：

316.7ºC

Safety Information

GHS Classification：

|Warning|H302 (88.89%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P272, P273, P280, P301+P312, P302+P352, P304+P312, P304+P340, P305+P351+P338, P312, P321, P322, P330, P332+P313, P333+P313, P337+P313, P362, P363, P391, P403+P233, P405, and P501|Aggregated GHS information provided by 9 companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|H315 (50%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P272, P273, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P333+P313, P337+P313, P362, P363, P403+P233, P405, and P501|Aggregated GHS information provided by 10 companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

Drug Indication：

Duodenal ulcer, Gastric ulcer, Gastro-oesophageal reflux disease, Peptic ulcer, site unspecified, Zollinger-Ellison syndrome

MeSH：

Various agents with different action mechanisms used to treat or ameliorate PEPTIC ULCER or irritation of the gastrointestinal tract. This has included ANTIBIOTICS to treat HELICOBACTER INFECTIONS; HISTAMINE H2 ANTAGONISTS to reduce GASTRIC ACID secretion; and ANTACIDS for symptomatic relief. (See all compounds classified as Anti-Ulcer Agents.)|Compounds that inhibit H(+)-K(+)-EXCHANGING ATPASE. They are used as ANTI-ULCER AGENTS and sometimes in place of HISTAMINE H2 ANTAGONISTS for GASTROESOPHAGEAL REFLUX. (See all compounds classified as Proton Pump Inhibitors.)

MeSH Entry Terms：

H 168 68|Esomeprazole

Omeprazole sodium Use and Manufacturing

Uses

Anti Ulceratives

Use Classification：

Human Drugs -> EU pediatric investigation plans|Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients

Computed Properties

Molecular Weight:368.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:5
Exact Mass:368.10448193
Monoisotopic Mass:368.10448193
Topological Polar Surface Area:96.3
Heavy Atom Count:25
Complexity:453
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

Drug Function and Efficacy

This product is a proton pump inhibitor of gastric parietal cells. It can specifically inhibit the secretory microtubules and tubular vesicles in the cytoplasm of the parietal cell apical membrane, thereby effectively inhibiting the secretion of gastric acid. Since H, K-ATPase is the last process of acid secretion of parietal cells, this product has a strong acid inhibition ability. It can not only non-competitively inhibit gastric acid secretion caused by gastrin, histamine, choline, food, and stimulation of the vagus nerve, but also inhibit part of the basic gastric acid secretion that is not affected by choline or H2 receptor blockers. It also has a strong and lasting inhibitory effect on gastric acid secretion caused by dibutyl cyclic adenosine monophosphate (DCAMP) stimulation that cannot be inhibited by H2 receptor antagonists. This product also has an inhibitory effect on pepsin secretion, has no obvious change in gastric mucosal blood flow, and does not affect body temperature, gastric cavity temperature, arterial blood pressure, venous hemoglobin, arterial oxygen partial pressure, carbon dioxide partial pressure and arterial blood pH.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Omeprazole Sodium for Injection
Ingredients	Omeprazole sodium.
Indication	Because this product can reduce gastric acidity, the absorption of some drugs may be changed. Therefore, the absorption of ketoconazole and itraconazole will be reduced when treated with omeprazole or other acid inhibitors or antacids. Omeprazole is metabolized in the liver by cytochrome P4502C19 (CYP2C19), which will prolong the clearance of other enzymatic products such as diazepam, warfarin (R warfarin) and phenytoin. This product should be monitored when used in combination with warfarin and phenytoin, and the dose of warfarin or phenytoin should be reduced if necessary. Patients who continue to use phenytoin are given 20 mg of this product once a day, and the blood concentration of phenytoin is not affected. Similarly, patients who continue to use warfarin are given 20 mg of this product once a day, and the clotting time is not changed. When omeprazole is used in combination with clarithromycin, their blood concentrations will increase. However, there is no interaction when used in combination with metronidazole or amoxicillin. These antibiotics combined with omeprazole can eradicate H. pylori.
Specifications	40mg (calculated as omeprazole C17H19N3O3S)
Manufacturer	CSPC OUYI Pharmaceutical Co., Ltd.

Omeprazole sodium
Indication	(1) This product can prolong the efficacy of diazepam, phenytoin sodium and other drugs metabolized by the liver. If this product is used in combination with phenytoin sodium, the condition should be carefully monitored and the dose of phenytoin sodium should be reduced as appropriate. (2) It may interact with drugs metabolized by the cytochrome P450 enzyme system (such as warfarin).
Manufacturer	Zhejiang Huayi Pharmaceutical Co., Ltd.

Omeprazole Sodium for Injection
Ingredients	Omeprazole sodium.
Indication	Because this product can reduce gastric acidity, the absorption of some drugs may be changed. Therefore, the absorption of ketoconazole and itraconazole will be reduced when treated with omeprazole or other acid inhibitors or antacids. Omeprazole is metabolized in the liver by cytochrome P4502C19 (CYP2C19), which will prolong the clearance of other enzymatic products such as diazepam, warfarin (R warfarin) and phenytoin. This product should be monitored when used in combination with warfarin and phenytoin, and the dose of warfarin or phenytoin should be reduced if necessary. Patients who continue to use phenytoin are given 20 mg of this product once a day, and the blood concentration of phenytoin is not affected. Similarly, patients who continue to use warfarin are given 20 mg of this product once a day, and the clotting time is not changed. When omeprazole is used in combination with clarithromycin, their blood concentrations will increase. However, there is no interaction when used in combination with metronidazole or amoxicillin. These antibiotics combined with omeprazole can eradicate H. pylori.
Specifications	(Calculated as C17H19N3O3S) 40mg
Manufacturer	INNER MONGOLIA BAIYI Pharmaceutical Co., Ltd.

See More Related Drugs

Registered Holders

China CHINO PHARMA Ltd

China
Active
Beijing Continent Pharmaceuticals Co., Ltd.

China
Active
AstraZeneca Investment (China) Co., Ltd.

China
Active

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