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Butoconazole nitrate

Butoconazole nitrate structure

CAS No:
64872-77-1
Formula:
C19H17Cl3N2S.HNO3
Chemical Name:
Butoconazole nitrate
Synonyms:
1H-Imidazole,1-[4-(4-chlorophenyl)-2-[(2,6-dichlorophenyl)thio]butyl]-,nitrate (1:1);1H-Imidazole,1-[4-(4-chlorophenyl)-2-[(2,6-dichlorophenyl)thio]butyl]-,(±)-,mononitrate;1H-Imidazole,1-[4-(4-chlorophenyl)-2-[(2,6-dichlorophenyl)thio]butyl]-,mononitrate;Butoconazole nitrate;(±)-Butoconazole nitrate;Gynomyk;RS 35887;Femstat;RS 35887-00-10-3;Butaconazole nitrate;67085-14-7;1427453-81-3
Categories:
Active Pharmaceutical Ingredients > Synthetic Anti-infective Drugs

Description

Butoconazole nitrate is an anti-fungal agent.Target: Antifungalbutoconazole 1-BSR is an effective and safe alternative to longer-term therapy with miconazole nitrate (seven days) for vulvovaginal candidiasis [1]. A sustained-release (SR) bioadhesive vaginal cream (2% butoconazole nitrate) has incorporated VagiSite technology, a topical drug delivery system that allows SR of the drug [2].

Butoconazole nitrate is an organic nitrate salt obtained by reaction of equimolar amounts of butaconazole and nitric acid. An antifungal agent, it is used in gynaecology for treatment of vulvovaginal infections caused by Candida species, particularly Candida albicans. It is an organic nitrate salt, an aryl sulfide, a member of imidazoles, an imidazole antifungal drug and a conazole antifungal drug. It contains a butoconazole(1+).

Butoconazole nitrate Basic Attributes

Molecular Weight：

474.78900

Exact Mass：

473.01300

EC Number：

613-721-6

DSSTox ID：

DTXSID6045452

HScode：

2933290090

Characteristics

PSA：

109.17000

XLogP3：

6.81250

Appearance：

white solid

Melting Point：

162-163 °C

Boiling Point：

566.9ºC at 760 mmHg

Flash Point：

296.7ºC

Storage Conditions：

-20ºC Freezer

Toxicity：

LD50 in mice, male, female rats (mg/kg): >3200, >3200, 1720 orally; >1600, 940, 940 i.p. (Walker)

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

Marks：

Precautionary statement(s)：

P301 + P312 + P330

Hazard Statements：

H302

GHS Classification：

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P301+P312, P330, and P501|Aggregated GHS information provided by 41 companies from 3 notifications to the ECHA C&L Inventory.

Drug Information

MeSH：

Substances that destroy fungi by suppressing their ability to grow or reproduce. They differ from FUNGICIDES, INDUSTRIAL because they defend against fungi present in human or animal tissues. (See all compounds classified as Antifungal Agents.)

MeSH Entry Terms：

1-(4-(4-chlorophenyl)-2-(2,6-dichlorophenylthio)-n-butyl)-1H-imidazole

Butoconazole nitrate Use and Manufacturing

Uses

Buconazole nitrate raw material is an imidazole derivative with antifungal activity, and Buconazole nitrate is an imidazole antifungal drug. Mainly used to treat candidiasis.

Use Classification：

Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients

Computed Properties

Molecular Weight:474.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:7
Exact Mass:473.013446
Monoisotopic Mass:473.013446
Topological Polar Surface Area:109
Heavy Atom Count:29
Complexity:408
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

Drug Function and Efficacy

Extract from the above information

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Butoconazole nitrate
Specifications	－－－－
Manufacturer	Nanjing White Whale Pharmaceutical Co., Ltd.

Butoconazole nitrate vaginal cream
Specifications	5 g: 100 mg

Butoconazole nitrate vaginal cream
Ingredients	Butoconazole nitrate.
Indication	Drug interactions may occur if used with other drugs. Please consult your doctor or pharmacist for details.
Specifications	5g:0.1g
Manufacturer	Dihon Pharmaceutical Group Co., Ltd.

Registered Holders

Nanjing White Whale Pharmaceutical Co., Ltd.

China
Active
Derivados Quimicos sau

United States
Active
QUIMICA SINTETICA SA

Spain
Inactive

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