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Atorvastatin

Atorvastatin structure

CAS No:
134523-00-5
Formula:
C33H35FN2O5
Chemical Name:
Atorvastatin
Synonyms:
1H-Pyrrole-1-heptanoic acid,2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-,(βR,δR)-;1H-Pyrrole-1-heptanoic acid,2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-,[R-(R*,R*)]-;(βR,δR)-2-(4-Fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid;(βR,δR)-2-(p-Fluorophenyl)-β,δ-dihydroxy-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)pyrrole-1-heptanoic acid;Atorvastatin;Cardyl;(3R,5R)-7-[2-(4-Fluorophenyl)-5-isopropyl-3-phenyl-4-phenylcarbamoylpyrrol-1-yl]-3,5-dihydroxyheptanoic acid;Atorvastatin acid;Lipilou;Ator;Atorfit 20;Atorcor;Atofast;Atorin;Alip;Statofilm;Lipinon;Atorvox;Atoris;Atrox;Atavastatin;1: PN: WO2019129231 SEQID: 2 claimed sequence
Categories:
Active Pharmaceutical Ingredients > Circulatory System Drugs

Description

Atorvastatin is an inhibitor of HMG-CoA reductase used as a cholesterol-lowering medication that blocks the production of cholesterol. Target: HMG-CoA reductaseAtorvastatin is an inhibitor of HMG-CoA reductase used as a cholesterol-lowering medication that blocks the production of cholesterol. 81 patients were randomly assigned to receive either placebo or 2.5, 5, 10, 20, 40, or 80 mg atorvastatin once daily for 6 weeks. Plasma LDL cholesterol reductions from baseline were dose related,

Atorvastatin Basic Attributes

Molecular Weight：

1155.34000

Exact Mass：

558.64

HScode：

2942000000

Characteristics

PSA：

229.24000

XLogP3：

Density：

1.236 g/cm3

Melting Point：

159.1-190.6 °C

Boiling Point：

722.198ºC at 760 mmHg

Flash Point：

390.572ºC

Refractive Index：

1.603

Water Solubility：

Sodium salt soluble in water, 20.4 ug/mL (pH 2.1), 1.23 mg/mL (pH 6.0)

Storage Conditions：

Store at controlled room temperature 20-25 deg C.

Vapor Density：

6.95X10-25 mm Hg at 25 deg C (est)

Safety Information

Packing level：

III

Hazard category：

Transport codes：

UN 3261 8/PG 2

wgk germany：

hazard class code：

R20/21/22; R36/37/38

safety instructions：

S26-S36

Marks：

Stability/Shelf Life：

Stable under recommended storage conditions. /Atorvastatin calcium salt trihydrate/

Precautionary statement(s)：

P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, P501

Hazard Statements：

H315

Atorvastatin Use and Manufacturing

Antihyperlipoproteimic;HMG-CoA reductase inhibition

Computed Properties

Molecular Weight:558.6
XLogP3:5
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:12
Exact Mass:558.25300038
Monoisotopic Mass:558.25300038
Topological Polar Surface Area:112
Heavy Atom Count:41
Complexity:822
Defined Atom Stereocenter Count:2
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Material

Benzaldehyde

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