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7H-Pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid, 9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-, hydrate (2:1), (3S)-

7H-Pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid, 9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-, hydrate (2:1), (3S)- structure

CAS No:
138199-71-0
Formula:
C18H20FN3O4.¹/2H2O
Chemical Name:
7H-Pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid, 9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-, hydrate (2:1), (3S)-
Synonyms:
7H-Pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid,9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-,hydrate (2:1),(3S)-;7H-Pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid,9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-,hydrate (2:1),(S)-;Levofloxacin hydrate;Levofloxacin hemihydrate;Dynaquin;Leeflox
Categories:
Active Pharmaceutical Ingredients > Synthetic Anti-infective Drugs

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Description

Levofloxacin hydrate is an antibacterial agent that inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication.Target: AntibacterialLevofloxacin reduced bacterial load compared with placebo by 4.9-fold (95% confidence interval, 1.4-25.7; P=0.02) at day 7 but had no effect at any point on any marker of neutrophilic airway inflammation. In patients with a baseline bacterial load of more than 10(6) cfu/mL, levofloxacin treatment was associated with a 26.5% (95% conf

7H-Pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid, 9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-, hydrate (2:1), (3S)- Basic Attributes

Molecular Weight：

379.38300

Exact Mass：

379.15400

EC Number：

604-067-2

DSSTox ID：

DTXSID20160534

Characteristics

PSA：

84.24000

Density：

1.48g/cm3

Melting Point：

214-216ºC

Boiling Point：

571.5ºC at 760mmHg

Flash Point：

299.4ºC

Vapor Pressure：

6.7E-14mmHg at 25°C

Safety Information

Transport codes：

NONH for all modes of transport

hazard class code：

50/53

safety instructions：

S24/25

Marks：

Precautionary statement(s)：

P261-P263-P280-P342 + P311

Hazard Statements：

H302-H317-H334-H361d-H362

7H-Pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid, 9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-, hydrate (2:1), (3S)- Use and Manufacturing

S-(-)-Form of Ofloxacin. An antibiotic used against gram-negative organisms

Computed Properties

Molecular Weight:379.4
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:9
Rotatable Bond Count:2
Exact Mass:379.15434897
Monoisotopic Mass:379.15434897
Topological Polar Surface Area:74.3
Heavy Atom Count:27
Complexity:634
Defined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

Material

1-Methylpiperazine

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GMP Manufacture High Quality Levofloxacin Hemihydrate CAS 138199-71-0

CAS No.: 138199-71-0

Content: 99.00%

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Hainan Flying International Trade Co., L Contact Supplier

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CAS No.: 138199-71-0

Grade: Food grade

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high quality Levofloxacin Hemihydrate CAS NO.138199-71-0

CAS No.: 138199-71-0

Grade: Pharmaceutical Grade

Content: 99%

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GMP Manufacture Levofloxacin Hemihydrate CAS 138199-71-0

CAS No.: 138199-71-0

Grade: pharmaceutical grade

Content: 99.9%

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Guide of 7H-Pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid, 9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-, hydrate (2:1), (3S)-

Description
Basic Attributes
Characteristics
Safety Information
Use and Manufacturing
Computed Properties
Material
Recommended Suppliers
Latest News
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7H-Pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid, 9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-, hydrate (2:1), (3S)-

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