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Monensin sodium

Monensin sodium structure

CAS No:
22373-78-0
Formula:
C36H62O11.Na
Chemical Name:
Monensin sodium
Synonyms:
Monensin,sodium salt (1:1);1,6-Dioxaspiro[4.5]decane-7-butyric acid,2-[5-ethyltetrahydro-5-[tetrahydro-3-methyl-5-[tetrahydro-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyl-2H-pyran-2-yl]-2-furyl]-2-furyl]-9-hydroxy-β-methoxy-α,γ,2,8-tetramethyl-,monosodium salt;Monensin,monosodium salt;Monensin sodium salt;Monensin sodium;Rumensin;Sodium monensin;Coban 45;Coban;Monensin A sodium salt;NSC 343257;CRC Rumensin;Kexxtone;22136-43-2;1174161-37-5;1192220-11-3;1191082-56-0
Categories:
Active Pharmaceutical Ingredients > Antiparasitic Drugs

Description

Monensin sodium salt is an antibiotic secreted by the bacteria Streptomyces cinnamonensis.

An antiprotozoal agent produced by Streptomyces cinnamonensis. It exerts its effect during the development of first-generation trophozoites into first-generation schizonts within the intestinal epithelial cells. It does not interfere with hosts' development of acquired immunity to the majority of coccidial species. Monensin is a sodium and proton selective ionophore and is widely used as such in biochemical studies.

Monensin sodium Basic Attributes

Molecular Weight：

710.86800

Exact Mass：

710.42200

EC Number：

244-941-7

UNII：

1GS872GAFV

DSSTox ID：

DTXSID2045573

HScode：

29419090

Characteristics

PSA：

165.43000

XLogP3：

2.87390

Appearance：

almost white solid.

Melting Point：

267-269 °C

Boiling Point：

766.3ºC at 760 mmHg

Flash Point：

229.2ºC

Storage Conditions：

2-8ºC

Vapor Pressure：

4.13E-27mmHg at 25°C

Safety Information

Packing level：

Hazard category：

6.1(a)

Transport codes：

UN 3462 6.1/PG 2

wgk germany：

hazard class code：

R25

safety instructions：

S45

RTECS Number：

JH2830000

Marks：

Stability/Shelf Life：

Stable under normal temperatures and pressures.

Precautionary statement(s)：

P264-P301 + P310

Hazard Statements：

H300

GHS Classification：

|Danger|H300 (98.99%): Fatal if swallowed [Danger Acute toxicity, oral]|P264, P270, P301+P310, P321, P330, P405, and P501|Aggregated GHS information provided by 198 companies from 3 notifications to the ECHA C&L Inventory.|H300: Fatal if swallowed [Danger Acute toxicity, oral]|P260, P264, P270, P301+P310, P309+P311, P314, P321, P330, P405, and P501|P260, P261, P264, P270, P272, P280, P301+P310, P302+P352, P307+P311, P312, P314, P321, P322, P330, P333+P313, P361, P363, P405, and P501

Drug Information

MeSH：

Substances that destroy fungi by suppressing their ability to grow or reproduce. They differ from FUNGICIDES, INDUSTRIAL because they defend against fungi present in human or animal tissues. (See all compounds classified as Antifungal Agents.)|Substances that are destructive to protozoans. (See all compounds classified as Antiprotozoal Agents.)|Agents useful in the treatment or prevention of COCCIDIOSIS in man or animals. (See all compounds classified as Coccidiostats.)|Chemical agents that increase the permeability of CELL MEMBRANES to PROTONS. (See all compounds classified as Proton Ionophores.)|Chemical agents that increase the permeability of CELL MEMBRANES to SODIUM ions. (See all compounds classified as Sodium Ionophores.)

MeSH Entry Terms：

Coban

Monensin sodium Use and Manufacturing

Uses

1. Poliether antibiotic. Coccidiostat.
2. Antifungal
3. Antibacterial

Use Classification：

Animal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients

Computed Properties

Molecular Weight:692.9
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:11
Rotatable Bond Count:10
Exact Mass:692.41115704
Monoisotopic Mass:692.41115704
Topological Polar Surface Area:156
Heavy Atom Count:48
Complexity:1110
Defined Atom Stereocenter Count:17
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

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