Acesulfame potassium
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Acesulfame potassium
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CAS No:
55589-62-3
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Formula:
C4H5NO4S.K
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Chemical Name:
Acesulfame potassium
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Synonyms:
1,2,3-Oxathiazin-4(3H)-one,6-methyl-,2,2-dioxide,potassium salt (1:1);1,2,3-Oxathiazin-4(3H)-one,6-methyl-,2,2-dioxide,potassium salt;Acesulfame K;Sunett;Acesulfame potassium;6-Methyl-3,4-dihydro-1,2,3-oxathiazin-4-one 2,2-dioxide potassium salt;Potassium acesulfame;Sunnett;Otizon;E 950;Sweet One;Potassium acesulfamate;Sunett D;Potassium 3,4-dihydro-6-methyl-1,2,3-oxathiazine-4-one-2,2-dioxide;Sunnet Pharma Grade D;124030-40-6;133249-02-2;1017787-12-0
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CAS No:
Description
Acesulfame potassium is an artificial sweetener. Acesulfame potassium (long-term) affects cognitive functions, potentially via altering neuro-metabolic functions in mice[1].
Characteristics
68.82000
0.47680
White, odorless, free flowing crystalline powder
1.512g/cm3
68 °C
332.7ºC at 760 mmHg
155ºC
Very soluble in water, very slightly soluble in ethanol
0-6ºC
LD50 in rats (mg/kg): 7431 orally, 2243 i.p. (Mayer, Kemper)
Safety Information
NONH for all modes of transport
1
R36/37/38
S26
RP4489165
P264, P280, P305+P351+P338, P33, P313
H319
Acesulfame potassium Use and Manufacturing
A 50percent SO3-dichloromethane solution and a 21.7percent intermediate-dichloromethane solution were used.The high-pressure liquid advection pump continuously feeds into the microchannel reactor 1 for the cyclization reaction.The key reaction component of SO3 and the intermediate reaction molar ratio of 6:1, cyclizing agent and the intermediate solution of the feed volume ratio of 1:1.6;The cyclization solution enters the microchannel reactor 2 for hydrolysis, and the amount of water is 5 times the excess SO3.The control temperatures of the cyclization and hydrolysis reactors were 4.5°C and 1.5°C, respectively.The liquefaction hourly space velocity of the cyclization reactor was 1890 h-1.The product flowing from the hydrolysis reactor is phase separated, Dichloromethane extraction, water extraction three times and then neutralized by KOH aqueous solution, taking a little neutralizing solution diluted with water to a certain volume, The ASK concentration was analyzed by liquid chromatography and the ASK yield was calculated.The yield was 56.7percent.
'New generation', heat-stable sweetener that has not been suspected to cause cancer nor be genotoxic. Allelic variation of the Tas1r3 gene affects behavioral taste responses to this molecule, suggesting that it is a T1R3 receptor ligand.
Price Analysis
Drug Function and Efficacy
non-nutritive sweetener
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