Ciprofloxacin hydrochloride monohydrate
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Ciprofloxacin hydrochloride monohydrate
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CAS No:
86393-32-0
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Formula:
C17H18FN3O3.ClH.H2O
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Chemical Name:
Ciprofloxacin hydrochloride monohydrate
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Synonyms:
3-Quinolinecarboxylic acid,1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-,hydrochloride,hydrate (1:1:1);3-Quinolinecarboxylic acid,1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-,monohydrochloride,monohydrate;Ciprofloxacin hydrochloride monohydrate
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CAS No:
Description
Ciprofloxacin hydrochloride is a fluoroquinolone antibiotic, exhibiting potent antibacterial activity.
Ciprofloxacin hydrochloride hydrate is the monohydrate form of ciprofloxacin monohydrochloride. It has a role as an EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor, an antibacterial drug, a topoisomerase IV inhibitor and an antiinfective agent. It contains a ciprofloxacin hydrochloride (anhydrous).|Ciprofloxacin is a second generation fluoroquinolone antibiotic that is widely used in the therapy of mild-to-moderate urinary and respiratory tract infections caused by susceptible organisms. Ciprofloxacin has been linked to rare but convincing instances of liver injury that can be severe and even fatal.|Ciprofloxacin Hydrochloride is the hydrochloride salt form of ciprofloxacin, a fluoroquinolone related to nalidixic acid with antibacterial activity. Ciprofloxacin hydrochloride exerts its bactericidal effect by interfering with the bacterial DNA gyrase, thereby inhibiting the DNA synthesis and preventing bacterial cell growth.|A broad-spectrum antimicrobial carboxyfluoroquinoline.
Ciprofloxacin hydrochloride monohydrate Basic Attributes
385.82
385.120453
1308068-626-2
4BA73M5E37
DTXSID00273974
C47976
2933990090
Characteristics
73.9
2.71480
White or yellowish crystalline powder
318-320 °C
581.8°C at 760 mmHg
305.6ºC
soluble in water (35mg/ml).
0-6°C
2.85X10-13 mm Hg at 25 deg C (est)
Safety Information
IRRITANT
NONH for all modes of transport
3
R36/37/38:Irritating to eyes, respiratory system and skin .
S26-S36/37/39
VB1993800
Xi
The physical and chemical compatibilities of ciprofloxacin lactate infusion with other commonly used iv admin drugs /was investigated/ Ciprofloxacin lactate injection in a commercially available concn of 2 mg/ml was mixed with 15 iv drugs during a simulated Y-site injection. Of the 15 drugs /examined/ , only heparin, furosemide and teicoplanin were found to be incompatible with ciprofloxacin. /Ciprofloxacin lactate/
P264, P273, P280, P302+P352, P305+P351+P338, P321, P332+P313, P337+P313, P362, P501
H315
|Warning|H317 (10.34%): May cause an allergic skin reaction [Warning Sensitization, Skin]|P261, P264, P272, P273, P280, P302+P352, P305+P351+P338, P321, P333+P313, P337+P313, P363, and P501|Aggregated GHS information provided by 173 companies from 22 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Toxicity
Ciprofloxacin like other fluoroquinolones is associated with a low rate (1% to 3%) of serum enzyme elevations during therapy. These abnormalities are generally mild, asymptomatic and transient, resolving even with continuation of therapy. More importantly, ciprofloxacin has been linked to rare, but occasionally severe and even fatal cases of acute liver injury. The time to onset is typically short (2 days to 2 weeks) and the presentation is often abrupt with nausea, fatigue and abdominal pain, followed by dark urine and jaundice. The pattern of serum enzyme elevations can be either hepatocellular or cholestatic; cases with the shorter times to onset usually being more hepatocellular with markedly elevated ALT levels, and occasionally with rapid worsening of prothrombin time and early signs of hepatic failure. The onset of illness also may occur a few days after the medication is stopped. Cases with a cholestatic pattern of enzymes may run a prolonged course, but are usually self-limiting. Nevertheless, chronic cholestasis and vanishing bile duct syndrome have been reported with ciprofloxacin and other fluoroquinolones. Finally, the enzyme pattern can be initially hepatocellular and then evolve during the course of illness from a hepatocellular into a mixed or cholestatic pattern. Many (but not all) cases have had allergic manifestations with fever, rash and eosinophilia. Autoantibodies are usually not present.
Drug Information
Ciprofloxacin is a second generation fluoroquinolone antibiotic that is widely used in the therapy of mild-to-moderate urinary and respiratory tract infections caused by susceptible organisms. Ciprofloxacin has been linked to rare but convincing instances of liver injury that can be severe and even fatal.
Antiinfective Agents
Substances that inhibit the growth or reproduction of BACTERIA. (See all compounds classified as Anti-Bacterial Agents.)|Drugs and compounds which inhibit or antagonize the biosynthesis or actions of CYTOCHROME P-450 CYP1A2. (See all compounds classified as Cytochrome P-450 CYP1A2 Inhibitors.)|Compounds that inhibit the activity of DNA TOPOISOMERASE II. Included in this category are a variety of ANTINEOPLASTIC AGENTS which target the eukaryotic form of topoisomerase II and ANTIBACTERIAL AGENTS which target the prokaryotic form of topoisomerase II. (See all compounds classified as Topoisomerase II Inhibitors.)
Anhydrous, Ciprofloxacin Hydrochloride
Ciprofloxacin hydrochloride monohydrate Use and Manufacturing
The taste is broad-spectrum antibiotics. By inhibiting bacterial DNA gyrase, DNA synthesis and replication are blocked and bacteria die. It has strong antibacterial activity against Escherichia coli, Klebsiella spp. and other Enterobacteriaceae, and has better antibacterial effect against Pseudomonas aeruginosa, Staphylococcus aureus and Streptococcus pneumoniae than norfloxacin and pefloxacin. Used for otitis media, external otitis and periostitis caused by sensitive bacteria. Occasional middle ear pain and itching.
Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients
Computed Properties
Molecular Weight:385.8
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:3
Exact Mass:385.1204620
Monoisotopic Mass:385.1204620
Topological Polar Surface Area:73.9
Heavy Atom Count:26
Complexity:571
Covalently-Bonded Unit Count:3
Compound Is Canonicalized:Yes
Price Analysis
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Ciprofloxacin hydrochloride monohydrate
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