Zinc diethyldithiocarbamate

361.93

359.980072

238-270-9

ICW4708Z8G

DTXSID5021463

White powder

29302000

70.66000

2.31750

solid

1.47 g/cm³ @ Temp: 20 °C

172-176 °C

330.6°C (estimate)

204°(400°F)

Insoluble in water. soluble in benzene carbon disulfide and organic liquids.

Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.

1.1mmHg at 25°C

Oral-rat LDL0: 3340 mg/kg; Abdominal cavity-mouse LD50: 142 mg/kg

Flammable; burning produces toxic nitrogen oxides, sulfur oxide fumes; poisoning reaction: strong irritation to eyes, nose, throat

III

6.1

UN 3077 9/PG 3

3

22-36/37/38-43-50/53

24-37-60-61

ZH0350000

Xn,N

Warehouse ventilated, low temperature and dry

Stable under normal temperatures and pressures.

P260, P261, P264, P270, P272, P273, P280, P301+P312, P301+P330+P331, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P310, P314, P321, P330, P333+P313, P363, P391, P405, P501

H302

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal, aquatic, and plant life; and conformance with environmental and public health regulations.

Zinc diethyldithiocarbamate is an indirect food additive for use only as a component of adhesives.

|Warning|H302: Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P272, P273, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P333+P313, P337+P313, P362, P363, P391, P403+P233, P405, and P501|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P260, P261, P264, P270, P271, P272, P273, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P314, P321, P330, P332+P313, P333+P313, P337+P313, P362, P363, P391, P403+P233, P405, and P501|Aggregated GHS information provided by 315 companies from 19 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|H317: May cause an allergic skin reaction [Warning Sensitization, Skin]|P261, P272, P280, P302+P352, P321, P333+P313, P363, and P501

SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.

Strong irritant to eyes & mucous membranes.

Diethyldithiocarbamic acid zinc salt has been identified in rubber household and surgical gloves(1).

moderately toxic

LD50 Rabbit oral 400 mg/kg bw|LD50 Rat oral 3340 mg/kg|LD50 Mouse oral 142 mg/kg

Zinc diethyldithiocarbamate is used as an accelerator in vulcanization of rubber. Dithiocarbamates are frequently present in domestic rubber goods such as gloves, clothing & contraceptive sheaths, that may cause urticaria.

Ditiocarb Zinc is approved for use within allergenic epicutaneous patch tests which are indicated for use as an aid in the diagnosis of allergic contact dermatitis (ACD) in persons 6 years of age and older.

Substances that augment, stimulate, activate, potentiate, or modulate the immune response at either the cellular or humoral level. The classical agents (Freund's adjuvant, BCG, Corynebacterium parvum, et al.) contain bacterial antigens. Some are endogenous (e.g., histamine, interferon, transfer factor, tuftsin, interleukin-1). Their mode of action is either non-specific, resulting in increased immune responsiveness to a wide variety of antigens, or antigen-specific, i.e., affecting a restricted type of immune response to a narrow group of antigens. The therapeutic efficacy of many biological response modifiers is related to their antigen-specific immunoadjuvanticity. (See all compounds classified as Adjuvants, Immunologic.)|Chemicals that bind to and remove ions from solutions. Many chelating agents function through the formation of COORDINATION COMPLEXES with METALS. (See all compounds classified as Chelating Agents.)|Agents used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly. (See all compounds classified as Antiviral Agents.)

Carbon disulfide and its main metabolite 2-thiothiazolidine-4-carboxylic acid are metabolites common to almost all dithiocarbamates. A significant increase in urinary concentration of these compound has been observed for different conditions of exposure and for various dithiocarbamates.

The carbamates alone weakly activated estrogen- or progesterone-responsive reporter genes in breast and endometrial cancer cells. All of the carbamates decreased estradiol- or progesterone-induced reporter gene activity in the breast and endometrial cancer cells. In whole cell competition binding assays, the carbamates demonstrated a limited capacity to displace radiolabeled estrogen or progesterone from /estrogen receptor/ or /progesterone receptor/. /Carbamates/

Basic treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilation if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 mL/kg up to 200 mL of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal ... . /Dithiocarbamates and Related Compounds/|For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport ... . Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious or in severe respiratory distress patient. Hyperventilate if signs of cerebral edema are present. Monitor cardiac rhythm and treat arrhythmias if necessary ... . Start an IV with D5W /SRP: "To keep open", minimal flow rate/. Use lactated Ringer's if signs of hypovolemia are present. Watch for signs of fluid overload. Treat seizures with diazepam ... . For hypotension with signs of hypovolemia, administer fluid cautiously. Consider vasopressors for hypotension with a normal fluid volume. Watch for signs of fluid overload ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Dithiocarbamates and Related Compounds/|Persons who have absorbed any significant amount of thiocarbamates must avoid alcoholic beverages for at least three weeks. Disposition of thiocarbamates is slow, and their inhibitory effects on enzymes are slowly reversible. /Thiocarbamates/

/SIGNS AND SYMPTOMS/ Alcohol intolerance may result from exposure to dithiocarbamates. /Dithiocarbamates/|/SIGNS AND SYMPTOMS/ Strong irritant to eyes and mucous membranes.|/CASE REPORTS/ In Nov 1981 a 19-yr-old woman began work as a kitchen employee. In June 1982 she developed urticaria on wrists every time she washed dishes at work, where she wore cotton & Formi-rubber latex domestic gloves. Whealing began on wrists a few minutes after she began washing, & occasionally she had edema of eyelids. Symptoms lasted 0.5 hr after removal of gloves. Itching was intense, causing excoriations on arms. There were no signs of eczema. She had no history of skin disease or atopy. Immediate reactions were not observed in patch tests. In scratch chamber tests, a small piece of rubber gloves & /zinc diethyldithiocarbamate/ ZDC produced a weal greater than histamine control at 15 min. Patient used different gloves at work when test began & no urticaria appeared. ZDC seemed to be sufficiently absorbed by contact to cause immunologic urticaria & edema of eyelids. Passive transfer did not occur.

Ammonium Salt Ditiocarb

"ETHAZATE" /IS UNIROYAL CHEMICAL/ TRADEMARK FOR ZINC DIETHYLDITHIOCARBAMATE, A RUBBER ACCELERATOR.

All other chemical product and preparation manufacturing|Zinc, bis(N,N-diethylcarbamodithioato-.kappa.S,.kappa.S')-, (T-4)-: ACTIVE|SEED DISINFECTANT, FUNGICIDE.|Formi-rubber latex domestic gloves are made in France. One of ingredients is zinc diethyldithiocarbamate (ZDC) & the inner surface of the glove is cotton.

METHODS FOR CHROMATOGRAPHIC ANALYSIS OF CARBAMATES... FISHBEIN L, ZIELINSKI WL JR; CHROMATOGRAPHY OF CARBAMATES; CHROMAT REV 9: 37-101 (1967). TLC-SPECTROPHOTOFLUORIMETRIC METHOD IS SUITABLE FOR...VARIETY OF METAL DITHIOCARBAMATES; VAN HOOF F, HEYNDRICKX A; GHENT RIJKSUNIV FAC LANDBL MED 38: 911-16 (1973). /CARBAMATES/|The compounds are decomposed with HCL & the carbon disulfide evolved is collected in a soln of (CH2NH2)2 in MeCHOH. The NH2CS2H formed is titrated with KOH in the presence of Me2CO as indicator. Dithiocarbamates can be detected in range of 0.5 to 20 mumol with relative errors of approx 5%. ZDC recoveries on apples were 97%.