N-Acetyl-L-carnosine
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N-Acetyl-L-carnosine
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CAS No:
56353-15-2
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Formula:
C11H16N4O4
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Chemical Name:
N-Acetyl-L-carnosine
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Synonyms:
L-Histidine,N-acetyl-β-alanyl-;L-Histidine,N-(N-acetyl-β-alanyl)-;Histidine,N-(N-acetyl-β-alanyl)-,L-;N-Acetyl-β-alanyl-L-histidine;N-Acetylcarnosine;N-(N-Acetyl-β-alanyl)histidine;N-Acetyl-L-carnosine;Can-C;(S)-2-(3-Acetamidopropanamido)-3-(1H-imidazol-4-yl)propanoicacid;13523-80-3
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CAS No:
Description
N-Acetylcarnosine, a natural histidine-containing dipeptide, is a source of pharmacological principal L-carnosine. N-Acetylcarnosine is a potent ophthalmic drug in treatment of human cataracts[1].
Characteristics
124
-1.5
white to off-white powder
1.3±0.1 g/cm3
209-210°C
775.854°C at 760 mmHg
423.0±32.9 °C
1.563
Hygroscopic, -20°C Freezer, Under Inert Atmosphere
N-Acetyl-L-carnosine Use and Manufacturing
In a 500 mL reaction flask, Add anhydrous ethanol 300mL, 80 g of N-acetyl-β-alanine (0.611 mol)86.1 g L-histidine (0.555 mol), 98 g of DMC (0.582 mol), Heating up to 40 , Reaction for 3 hours, Cooling to 5 , Filter, The filter cake was rinsed with 150 mL of anhydrous ethanol, Solid-dried product (IV) 145g, The yield was 97.9percentHPLC purity> 98.8percent.
N-Acetylcarnosine (NAC) is a naturally occurring compound chemically related to the dipeptide carnosine. The NAC molecular structure is identical to carnosine with the exception that it carries an additional acetyl group. The acetylation makes NAC more resistant to degradation by carnosinase, an enzyme that breaks down carnosine to its constituent amino acids, beta-alanine and histidine.
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