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Diclofenac sodium

Diclofenac sodium structure

CAS No:
15307-79-6
Formula:
C14H11Cl2NO2.Na
Chemical Name:
Diclofenac sodium
Synonyms:
Benzeneacetic acid,2-[(2,6-dichlorophenyl)amino]-,sodium salt (1:1);Acetic acid,[o-(2,6-dichloroanilino)phenyl]-,monosodium salt;Benzeneacetic acid,2-[(2,6-dichlorophenyl)amino]-,monosodium salt;N-(2,6-Dichlorophenyl)-o-aminophenylacetic acid sodium salt;GP 45840;[o-(2,6-Dichloroanilino)phenyl]acetic acid sodium salt;Diclofenac sodium;Voltaren;Diclophenac sodium;Sodium [o-(2,6-dichloroanilino)phenyl]acetate;Sodium diclofenac;Voltarol;Diclofenac sodium salt;Feloran;Orthofen;2-(2,6-Dichloroanilino)phenylacetic acid sodium salt;Orthophen;Hyanalgese D;Inflaban;Naclof;Diklovit;SR 318B;Diclofen SR 100;Sorelmon;Voltaren Ophtha CD;Voltaren Ophtha;Voveran;Voldal;Rhumalgan;Kriplex;Effekton;Duravolten;Dicloreum;Evofenac;Diclo-Puren;Valetan;Neriodin;Dichronic;Novapirina;Dolobasan;Primofenac;Diclord;Diclo-Phlogont;Delphimix;Assaren;Prophenatin;Diclobenin;Xenid;Allvoran;Benfofen;Tsudohmin;Profenac;Fortfen;Diclofenac-Na Emulgel;Diclofenacsodium Emulgel;Dyclo;Diclokalium;Diclorep;Diclodyn;Diacron;Dyloject;Diclobene;Naclofen;Dicloberl Retard;Dicloberl;Dicloran CP;Diclofenac retard;Declophen;Naclofen Duo;diclotard;Refen retard;Refen;Diclon;Dicloflex;Panamor;Modifenac;Abitren;Olfen;Dedolor;Deflamat;Dicloran Plus;Dolaut;Dikloron;Saffrac;Daispas;Bolabomin;Voltral;Diclogesic;2-[2-[(2,6-Dichlorophenyl)amino]phenyl]acetic acid sodium salt;Neurodiclovit;Neurofenac;Phlogin;Diclomol;Dynapar;Voveran Plus;1147187-62-9
Categories:
Active Pharmaceutical Ingredients > Antipyretic Analgesics

Description

Diclofenac Sodium is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 nM, 1.3 nM for human COX-1 and COX-2 in CHO cells, and 5.1, 0.84 μM for ovine COX-1 and COX-2, respectively.

Diclofenac sodium is the sodium salt of diclofenac. It contains a diclofenac(1-).|Diclofenac Sodium is the sodium salt form of diclofenac, a benzene acetic acid derivate and nonsteroidal anti-inflammatory drug (NSAID) with analgesic, antipyretic and anti-inflammatory activity. Diclofenac sodium is a non-selective reversible and competitive inhibitor of cyclooxygenase (COX), subsequently blocking the conversion of arachidonic acid into prostaglandin precursors. This leads to an inhibition of the formation of prostaglandins that are involved in pain, inflammation and fever.|A non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. It is primarily available as the sodium salt.

Diclofenac sodium Basic Attributes

Molecular Weight：

318.13000

Exact Mass：

316.99900

EC Number：

239-346-4

UNII：

QTG126297Q

DSSTox ID：

DTXSID3037208

NCI Thesaurus Code：

C47984

HScode：

2922499990

Characteristics

PSA：

52.16000

XLogP3：

3.10240

Appearance：

white or off-white powder

Density：

0.563 g/cm³

Melting Point：

283-285 °C

Boiling Point：

412ºC at 760 mmHg

Flash Point：

203ºC

Water Solubility：

H2O: 50 mg/mL

Storage Conditions：

Keep tightly closed.

Collision Cross Section：

157.2 Å² [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

Safety Information

Packing level：

III

Hazard category：

6.1(b)

Transport codes：

UN 2811

wgk germany：

hazard class code：

R25

safety instructions：

S22-S36/37-S45

RTECS Number：

AG6330000

Marks：

Stability/Shelf Life：

Stable.

Precautionary statement(s)：

P301 + P310

Hazard Statements：

H301

GHS Classification：

|Danger|H301 (77.32%): Toxic if swallowed [Danger Acute toxicity, oral]|P201, P202, P260, P264, P270, P273, P280, P281, P301+P310, P301+P312, P302+P352, P305+P351+P338, P308+P313, P314, P321, P330, P332+P313, P337+P313, P362, P391, P405, and P501|Aggregated GHS information provided by 291 companies from 38 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

Drug Indication：

Treatment of pain|Treatment of inflammation, Treatment of pain|Treatment of musculoskeletal and connective tissue pain and discomfort|Treatment of musculoskeletal and connective tissue pain|Rheumatoid arthritis, Ankylosing spondylitis, Osteoarthritis

MeSH：

Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions.They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects. (See all compounds classified as Anti-Inflammatory Agents, Non-Steroidal.)|Compounds or agents that combine with cyclooxygenase (PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES) and thereby prevent its substrate-enzyme combination with arachidonic acid and the formation of eicosanoids, prostaglandins, and thromboxanes. (See all compounds classified as Cyclooxygenase Inhibitors.)

MeSH Entry Terms：

Dichlofenal

Diclofenac sodium Use and Manufacturing

Uses

A nonsteroidal anti-inflammatory compound and cyclooxygenase (COX) inhibitor.This product is a powerful antipyretic analgesic and anti-inflammatory drug. Its anti-inflammatory effect is 2-2.5 times that of indomethacin, 26-50 times stronger than acetylsalicylic acid. It is suitable for rheumatoid arthritis, osteoarthropathy, pain relief after surgery and fever caused by various reasons. Used as an anti-inflammatory analgesic, standard NSAID and cyclooxygenase (COX) inhibitor; used as a selective matrix for CYP2C9

Use Classification：

Human Drugs -> EU pediatric investigation plans|Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients|Animal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients

Computed Properties

Molecular Weight:318.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:316.9986282
Monoisotopic Mass:316.9986282
Topological Polar Surface Area:52.2
Heavy Atom Count:20
Complexity:310
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

Material

1-Butanol

2,6-Dichlorophenol

Downstream Products

2,6-Dichlorophenol

Drug Function and Efficacy

Inhibits cyclooxygenase activity, thereby blocking the conversion of arachidonic acid to prostaglandins; promotes the combination of arachidonic acid and triglycerides, reduces the concentration of free arachidonic acid in cells, and indirectly inhibits the synthesis of leukotrienes

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Chlorphenamine yellow sensitive tablets
Ingredients	This product is a compound preparation, and its components per tablet are: diclofenac sodium 15 mg, artificial bezoar 15 mg, and chlorpheniramine maleate 2.5 mg.
Indication	1. When used with aspirin or other salicylic acid drugs, the efficacy does not increase, but the incidence of gastrointestinal adverse reactions and bleeding tendency increases. 2. This product can reduce the effects of insulin and other hypoglycemic drugs, causing blood sugar to rise. 3. Aspirin can reduce the bioavailability of this product. 4. This product can enhance the effects of amantadine, anticholinergic drugs, phenothiazines, and antisympathomimetic drugs. 5. When this product is taken with tricyclic antidepressants, it can enhance the efficacy of the latter.
Specifications	Diclofenac sodium 15mg, artificial bezoar 15mg, chlorpheniramine maleate 2.5mg
Manufacturer	Hainan Asia Pharmaceutical Co., Ltd.

Chlorphenamine yellow sensitive tablets
Ingredients	This product is a compound preparation, and its components per tablet are: diclofenac sodium 15 mg, artificial bezoar 15 mg, and chlorpheniramine maleate 2.5 mg.
Indication	1. When used with aspirin or other salicylic acid drugs, the efficacy does not increase, but the incidence of gastrointestinal adverse reactions and bleeding tendency increases. 2. This product can reduce the effects of insulin and other hypoglycemic drugs, causing blood sugar to rise. 3. Aspirin can reduce the bioavailability of this product. 4. This product can enhance the effects of amantadine, anticholinergic drugs, phenothiazines, and antisympathomimetic drugs. 5. When this product is taken with tricyclic antidepressants, it can enhance the efficacy of the latter.
Specifications	This product is a compound preparation. Each tablet contains 15 mg of diclofenac sodium, 15 mg of artificial bezoar, and 2.5 mg of chlorpheniramine maleate.
Manufacturer	Shandong XinYi Pharmaceutical Co., Ltd.

Diclofenac Sodium Cream
Ingredients	The main ingredient is diclofenac sodium
Indication	If you are using other medicines, please consult your physician or pharmacist before using this product.
Specifications	25g:0.75g

See More Related Drugs

Registered Holders

AMOLI ORGANICS (A DIVISION OF UMEDICA LABORATORIES PVT LTD)

United States
Active
SYN-TECH CHEM AND PHARM CO LTD

United States
Active
MACLEODS PHARMACEUTICALS LTD

India
Active

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