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Ceftiofur hydrochloride

Ceftiofur hydrochloride structure

CAS No:
103980-44-5
Formula:
C19H17N5O7S3.ClH
Chemical Name:
Ceftiofur hydrochloride
Synonyms:
5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid,7-[[(2Z)-2-(2-amino-4-thiazolyl)-2-(methoxyimino)acetyl]amino]-3-[[(2-furanylcarbonyl)thio]methyl]-8-oxo-,hydrochloride (1:1),(6R,7R)-;5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid,7-[[(2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]-3-[[(2-furanylcarbonyl)thio]methyl]-8-oxo-,monohydrochloride,[6R-[6α,7β(Z)]]-;5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid,7-[[(2Z)-(2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]-3-[[(2-furanylcarbonyl)thio]methyl]-8-oxo-,monohydrochloride,(6R,7R)-;Ceftiofur hydrochloride;U 64279A;Excenel;U 67279A;Excenel RTU;Spectramast LC;Aviar;Cefalus
Categories:
Active Pharmaceutical Ingredients > Antibiotics

Description

Ceftiofur hydrochloride is a semisynthetic antibiotic, with activity against various gram-positive and gram-negative, aerobic and anaerobic bacteria encountered by domestic animals[1].

Ceftiofur Hydrochloride is the hydrochloride salt form of ceftiofur, a semisynthetic, beta-lactamase-stable, broad-spectrum, third-generation cephalosporin with antibacterial activity. Ceftiofur binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. PBPs are enzymes involved in the terminal stages of assembling the bacterial cell wall and in reshaping the cell wall during growth and division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis.

Ceftiofur hydrochloride Basic Attributes

Molecular Weight：

560.02

Exact Mass：

559.005676

EC Number：

1312995-182-4

UNII：

6822A07436

NCI Thesaurus Code：

C76174

HScode：

2941905990

Characteristics

PSA：

256 Å²

XLogP3：

2.69300

Appearance：

off-white solid

Melting Point：

>190°C (dec.)

Boiling Point：

814.1°C at 760 mmHg

Flash Point：

446.1ºC

Storage Conditions：

-20°C Freezer

Vapor Pressure：

5.14E-28mmHg at 25°C

Safety Information

Transport codes：

NONH for all modes of transport

GHS Classification：

|Danger|H317 (60.67%): May cause an allergic skin reaction [Warning Sensitization, Skin]|P260, P261, P272, P280, P285, P302+P352, P304+P341, P314, P321, P333+P313, P342+P311, P363, and P501|Aggregated GHS information provided by 90 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH：

Substances that inhibit the growth or reproduction of BACTERIA. (See all compounds classified as Anti-Bacterial Agents.)

MeSH Entry Terms：

ceftiofur

Ceftiofur hydrochloride Use and Manufacturing

Uses

An antibacterial

Use Classification：

Animal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients

Computed Properties

Molecular Weight:560.0
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:13
Rotatable Bond Count:9
Exact Mass:559.0056891
Monoisotopic Mass:559.0056891
Topological Polar Surface Area:256
Heavy Atom Count:35
Complexity:945
Defined Atom Stereocenter Count:2
Defined Bond Stereocenter Count:1
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

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