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Artemisinin

Artemisinin structure

CAS No:
63968-64-9
Formula:
C15H22O5
Chemical Name:
Artemisinin
Synonyms:
3,12-Epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10(3H)-one,octahydro-3,6,9-trimethyl-,(3R,5aS,6R,8aS,9R,12S,12aR)-;3,12-Epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10(3H)-one,octahydro-3,6,9-trimethyl-,[3R-(3α,5aβ,6β,8aβ,9α,12β,12aR*)]-;(3R,5aS,6R,8aS,9R,12S,12aR)-Octahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10(3H)-one;Qing Hau Sau;Artemisinin;Arteannuin;Qinghaosu;Qing Hau Su;(+)-Artemisinin;Qinghosu;(+)-Arteannuin;(+)-Qinghaosu;Huanghuahaosu;Artemisine;QHS;NSC 369397;Artemef;Artemisinine;HC 101A;ARTIVeda;PulmoHeal;91487-93-3
Categories:
Cosmetic Ingredient > Skin Conditioning

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Description

Artemisinin is an anti-malarial drug isolated from the aerial parts of Artemisia annua L. plants.

Artemisinin Basic Attributes

Molecular Weight：

282.33

Exact Mass：

282.33

EC Number：

1806241-263-5

HScode：

29322985

Characteristics

PSA：

54 Å²

XLogP3：

2.9 (LogP)

Appearance：

Crystalline Solid

Density：

1.300 g/cm³

Melting Point：

156-157 °C

Boiling Point：

389.899°C at 760 mmHg

Flash Point：

172.0±27.9 °C

Refractive Index：

1.533

Water Solubility：

soluble to 100mM in DMSO and to 75mM in ethanol

Storage Conditions：

Store at +4°C

Toxicity：

Abdominal-rat LD50: 2571 mg/kg; Abdominal-mouse LD50: 1558 mg/kg

Flammability characteristics：

Flammable; burning produces irritating fumes

Specific rotation：

76 º (c=0.5,MeOH)

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

safety instructions：

22-24/25

RTECS Number：

KD4170000

Storage features：

Ventilated, low temperature and dry

Stability/Shelf Life：

Stable. Combustible. Incompatible with strong oxidizing agents, acids, acid chlorides, acid anhydrides. May absorb, and react with, carbon dioxide from the air.

Toxicity

Toxicity class：

moderately

Artemisinin Use and Manufacturing

Methods of Manufacturing

It is extracted from the leaves of Artemisia annua (Artemisia annua L). In addition to artemisinin, artemether and artesunate sodium are also produced in my country.

Uses

An antimalarial agent that inhibits VEGF expression and NOS2.Artemisia annua is used as an antimalarial drug. Clinical application has proved that artemisinin and its derivatives have special effects on malaria and falciparum malaria, especially Artemtherin, which is more effective than other artemisinin-killing malaria parasites. The role of asexual cells in cells is stronger. It has the advantages of high efficiency, quick effect, low toxicity and no cross resistance with chloroquine. It can be used not only for treatment but also for emergency treatment. It is suitable for all kinds of malaria, such as falciparum malaria, vivax malaria, chloroquine-resistant malaria and cerebral malaria. Including the dangerous type.

Drug Function and Efficacy

Artemisinin is a sesquiterpene lactone drug with peroxide groups extracted from the traditional Chinese medicine Artemisia annua. Its effect on the ultrastructure of the erythrocytic stage of Plasmodium malariae is mainly the change of the membrane structure of the parasite. The drug first acts on the food vacuole membrane, the surface membrane, mitochondria, and the endoplasmic reticulum. In addition, it also has a certain effect on the chromatin in the nucleus. It suggests that the mode of action of artemisinin is mainly to interfere with the function of the surface membrane-mitochondria. It may be that artemisinin acts on the food vacuole membrane, thereby blocking the earliest stage of nutrient intake, causing the parasite to starve for amino acids more quickly, quickly forming autophagic vacuoles, and continuously excreting them from the parasite, causing the parasite to lose a large amount of cytoplasm and die. The uptake of tritium-labeled isoleucine by Plasmodium falciparum cultured in vitro also shows that its initial mode of action may be to inhibit the synthesis of protozoan proteins.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Artemisinin
Ingredients	Artemisinin
Indication	1. This product must be used in combination with primaquine to cure vivax malaria. 2. It has a synergistic effect when used in combination with trimethoprim and can reduce recent relapse or recurrence.
Manufacturer	KPC Pharmaceuticals, Inc.

Artemisinin
Ingredients	Artemisinin
Indication	1. This product must be used in combination with primaquine to cure vivax malaria. 2. It has a synergistic effect when used in combination with trimethoprim and can reduce recent relapse or recurrence.
Specifications	API

Artemisinin
Ingredients	Artemisinin
Indication	1. This product must be used in combination with primaquine to cure vivax malaria. 2. It has a synergistic effect when used in combination with trimethoprim and can reduce recent relapse or recurrence.
Manufacturer	Guangzhou Hanfang Pharmaceutical Company Limited

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Xiangxi Holley Pharmaceutical Co., Ltd.

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Sichuan Xieli Pharmaceutical Co., Ltd.

China
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