Artemisinin
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Artemisinin
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CAS No:
63968-64-9
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Formula:
C15H22O5
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Chemical Name:
Artemisinin
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Synonyms:
3,12-Epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10(3H)-one,octahydro-3,6,9-trimethyl-,(3R,5aS,6R,8aS,9R,12S,12aR)-;3,12-Epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10(3H)-one,octahydro-3,6,9-trimethyl-,[3R-(3α,5aβ,6β,8aβ,9α,12β,12aR*)]-;(3R,5aS,6R,8aS,9R,12S,12aR)-Octahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10(3H)-one;Qing Hau Sau;Artemisinin;Arteannuin;Qinghaosu;Qing Hau Su;(+)-Artemisinin;Qinghosu;(+)-Arteannuin;(+)-Qinghaosu;Huanghuahaosu;Artemisine;QHS;NSC 369397;Artemef;Artemisinine;HC 101A;ARTIVeda;PulmoHeal;91487-93-3
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CAS No:
Description
Artemisinin is an anti-malarial drug isolated from the aerial parts of Artemisia annua L. plants.
Characteristics
54 Ų
2.9 (LogP)
Crystalline Solid
1.300 g/cm3
156-157 °C
389.899°C at 760 mmHg
172.0±27.9 °C
1.533
soluble to 100mM in DMSO and to 75mM in ethanol
Store at +4°C
Abdominal-rat LD50: 2571 mg/kg; Abdominal-mouse LD50: 1558 mg/kg
Flammable; burning produces irritating fumes
76 º (c=0.5,MeOH)
Safety Information
NONH for all modes of transport
2
22-24/25
KD4170000
Ventilated, low temperature and dry
Stable. Combustible. Incompatible with strong oxidizing agents, acids, acid chlorides, acid anhydrides. May absorb, and react with, carbon dioxide from the air.
Artemisinin Use and Manufacturing
It is extracted from the leaves of Artemisia annua (Artemisia annua L). In addition to artemisinin, artemether and artesunate sodium are also produced in my country.
An antimalarial agent that inhibits VEGF expression and NOS2.Artemisia annua is used as an antimalarial drug. Clinical application has proved that artemisinin and its derivatives have special effects on malaria and falciparum malaria, especially Artemtherin, which is more effective than other artemisinin-killing malaria parasites. The role of asexual cells in cells is stronger. It has the advantages of high efficiency, quick effect, low toxicity and no cross resistance with chloroquine. It can be used not only for treatment but also for emergency treatment. It is suitable for all kinds of malaria, such as falciparum malaria, vivax malaria, chloroquine-resistant malaria and cerebral malaria. Including the dangerous type.
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