Propafenone hydrochloride
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Propafenone hydrochloride
structure -
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CAS No:
34183-22-7
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Formula:
C21H27NO3.ClH
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Chemical Name:
Propafenone hydrochloride
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Synonyms:
1-Propanone,1-[2-[2-hydroxy-3-(propylamino)propoxy]phenyl]-3-phenyl-,hydrochloride (1:1);Propiophenone,2′-[2-hydroxy-3-(propylamino)propoxy]-3-phenyl-,hydrochloride;1-Propanone,1-[2-[2-hydroxy-3-(propylamino)propoxy]phenyl]-3-phenyl-,hydrochloride;Propafenone hydrochloride;Rytmonorm;Rythmol;Arythmol;Pronon;1-[2-[2-Hydroxy-3-(propylamino)propoxy]phenyl]-3-phenylpropan-1-one hydrochloride;163858-56-8
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Categories:
Active Pharmaceutical Ingredients > Circulatory System Drugs
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CAS No:
Description
Propafenone Hydrochloride is a class of anti-arrhythmic medication, which treats illnesses associated with rapid heart beats such as atrial and ventricular arrhythmias.Target: Sodium ChannelPropafenone Hydrochloride is a classic anti-arrhythmic medication, which treats illnesses associated with rapid heartbeats such as atrial and ventricular arrhythmias. According to the Allergic Rhinitis and its Impact on Asthma (ARIA) treatment guidelines, intranasal anti-histamines are recommended for
Propafenone hydrochloride is a hydrochloride that is the monohydrochloride salt of propafenone. It is a class 1C antiarrhythmic drug with local anesthetic effects, and is used in the management of supraventricular and ventricular arrhythmias. It has a role as an anti-arrhythmia drug. It contains a propafenone(1+).|An antiarrhythmia agent that is particularly effective in ventricular arrhythmias. It also has weak beta-blocking activity.
Characteristics
58.6
4.43430
White solid
165-1670C
519.6°C at 760 mmHg
268ºC
>56.7 [ug/mL]
2-8°C
LD50 in rats (mg/kg): 18.8 i.v.; 700 orally (Hapke, Prigge)
177.2 Ų [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]
Safety Information
NONH for all modes of transport
3
46-22
53-36/37/39-45
UH2833000
T,Xn
P301 + P312 + P330
H302
|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P312, P304+P340, P312, P322, P330, P363, and P501|Aggregated GHS information provided by 151 companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Drug Information
Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade. (See all compounds classified as Anti-Arrhythmia Agents.)|A class of drugs that inhibit the activation of VOLTAGE-GATED SODIUM CHANNELS. (See all compounds classified as Voltage-Gated Sodium Channel Blockers.)
Apo-Propafenone
Propafenone hydrochloride Use and Manufacturing
A sodium channel protein inhibitor.
Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients
Drug Function and Efficacy
The specific pharmacological effect is not clear from the above information
Registered Holders
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PHARMAZELL GMBH
Active
France
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Fermion Oy
Active
Finland
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PROCOS S.P.A.
Active
Italy
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