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Propafenone Hydrochloride

Propafenone Hydrochloride structure

CAS No:
34183-22-7
Formula:
C21H28ClNO3
Chemical Name:
Propafenone Hydrochloride
Synonyms:
1-[2-(2-HYDROXY-3-[PROPYLAMINO]-PROPOXY)PHENYL]-3-PHENYL-1-PROPANONE HYDROCHLORIDE;1-[2-[2-hydroxy-3-(propylamino)propoxy]phenyl]-3-phenylpropan-1-one hydrochloride;PROPAFENONE HCL;rytmonorm;sa79;wz884;Arythmol;Pronon
Categories:
Active Pharmaceutical Ingredients > Circulatory System Drugs

Description

Propafenone Hydrochloride is a class of anti-arrhythmic medication, which treats illnesses associated with rapid heart beats such as atrial and ventricular arrhythmias.Target: Sodium ChannelPropafenone Hydrochloride is a classic anti-arrhythmic medication, which treats illnesses associated with rapid heartbeats such as atrial and ventricular arrhythmias. According to the Allergic Rhinitis and its Impact on Asthma (ARIA) treatment guidelines, intranasal anti-histamines are recommended for

Propafenone hydrochloride is a hydrochloride that is the monohydrochloride salt of propafenone. It is a class 1C antiarrhythmic drug with local anesthetic effects, and is used in the management of supraventricular and ventricular arrhythmias. It has a role as an anti-arrhythmia drug. It contains a propafenone(1+).|An antiarrhythmia agent that is particularly effective in ventricular arrhythmias. It also has weak beta-blocking activity.

Propafenone hydrochloride is a class I anti-arrhythmic agent with basic local anaesthetic and membrane-stabilizing properties. Some P-adrenergic blocking action has also been described. Propafenone decreases the depolarization velocity and slows conduction in the His-Purkinje system with resultant increase in the PR interval and the QRS complex. Propafenone is used in the treatment of paroxysmal supraventricular tachycardias and ventricular arrhythmias.Propafenone should not be used in uncontrolled cardiac failure, severe obstructive pulmonary disease or marked hypotension. Propafenone may worsen myasthenia gravis.

White Solid

Propafenone Hydrochloride Basic Attributes

Molecular Weight：

377.9

Exact Mass：

377.175781

EC Number：

251-867-9

NSC Number：

758640

Color/Form：

White to Off-White

HScode：

2922504500

Characteristics

λmax：

303nm(MeOH)(lit.)

PSA：

58.6

XLogP3：

4.43430

Appearance：

White solid

Melting Point：

165-1670C

Boiling Point：

519.6°C at 760 mmHg

Flash Point：

268ºC

Water Solubility：

>56.7 [ug/mL]

Storage Conditions：

2-8°C

Toxicity：

LD50 in rats (mg/kg): 18.8 i.v.; 700 orally (Hapke, Prigge)

Collision Cross Section：

177.2 Å² [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

Critical Temperature & Pressure：

2-8°C

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

T,Xn

safety instructions：

53-36/37/39-45

RTECS Number：

UH2833000

Marks：

T,Xn

Precautionary statement(s)：

P301 + P312 + P330

Hazard Statements：

46-22

GHS Classification：

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P312, P304+P340, P312, P322, P330, P363, and P501|Aggregated GHS information provided by 151 companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH：

Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade. (See all compounds classified as Anti-Arrhythmia Agents.)|A class of drugs that inhibit the activation of VOLTAGE-GATED SODIUM CHANNELS. (See all compounds classified as Voltage-Gated Sodium Channel Blockers.)

MeSH Entry Terms：

Apo-Propafenone

Propafenone Hydrochloride Use and Manufacturing

Uses

A sodium channel protein inhibitor.

Propafenone hydrochloride is a class IC antiarrhythmic agent used for the management of severe ventricular and supraventricular arrhythmias. It has beta-blocking and weak calcium channel blocking properties, as well as some negative inotropic activity. Propafenone is in a class of medications called antiarrhythmics. It works by acting on the heart muscle to improve the heart's rhythm.

Sodium channel blocker. Antiarrhythmic (class IC)

Use Classification：

Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients

Material

Benzaldehyde

Drug Function and Efficacy

The specific pharmacological effect is not clear from the above information

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Propafenone hydrochloride
Manufacturer	Zhejiang Hisun Pharmaceutical Co., Ltd.

Propafenone Hydrochloride Tablets
Ingredients	The main ingredient and chemical name of this product are: 3-phenyl-1-[2-[3-(propylamino)-2-hydroxypropoxy]-phenyl]-1-propanone hydrochloride
Indication	Combination with quinidine can slow down the metabolic process. Combination with local anesthetics increases the occurrence of central nervous system side effects. Propafenone can increase serum digoxin concentrations in a dose-dependent manner. Combination with propranolol and metoprolol can significantly increase their plasma concentrations and elimination half-life, but has no effect on propafenone. Combination with warfarin can increase warfarin blood concentrations and prothrombin time. Combination with cimetidine can increase the steady-state level of propafenone in the blood, but has no effect on its electrophysiological parameters.
Specifications	50mg
Manufacturer	Shandong Mingren Freda Pharmaceutical Co., Ltd.

Propafenone hydrochloride
Manufacturer	Henan Qixin Pharmaceutical Co., Ltd.

See More Related Drugs

Registered Holders

PHARMAZELL GMBH

France
Active
Fermion Oy

Finland
Active
PROCOS S.P.A.

Italy
Active

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Propafenone Hydrochloride Manufacturer Wholesale 99% Purity CAS 34183-22-7 Propafenone Hydrochloride

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Latest News on Propafenone Hydrochloride

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Guide of Propafenone Hydrochloride

Description
Basic Attributes
Characteristics
Safety Information
Drug Information
Use and Manufacturing
Material
Drug Function and Efficacy
Related Drugs
Registered Holders
Recommended Suppliers
Latest News
Learn More Other Chemicals

Propafenone Hydrochloride

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