Sodium Phosphate Monobasic Monohydrate
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Sodium Phosphate Monobasic Monohydrate
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CAS No:
10049-21-5
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Formula:
H4NaO5P
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Chemical Name:
Sodium Phosphate Monobasic Monohydrate
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Synonyms:
BOD PHOSPHATE BUFFER SOLUTION A;BUFFER COLOUR CODED SOLUTION PH 7 (PHOSPHATE) YELLOW;BUFFER COLOUR CODED CONCENTRATED SOLUTION PH 7 (PHOSPHATE) YELLOW;BUFFER CONCENTRATE, PH 7 (PHOSPHATE);BUFFER FOR BOD;BUFFER MDB 9.50;BUFFER PH 7.0 (PHOSPHATE);BUFFER, PHOSPHATE
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CAS No:
Description
Sodium dihydrogenphosphate monohydrate is a hydrate that is the monohydrate form of sodium dihydrogenphosphate. It contains a sodium dihydrogenphosphate.
Sodium Phosphate Monobasic Monohydrate is a reagent with very high buffering capacity widely used in molecular biology, biochemistry and chromatography. it can be used as a buffer to adjust pH. In medicine, it is sometimes used as a stimulant laxative before certain operations and medical procedures. Sodium Phosphate Monobasic Monohydrate is often used in foods and in water treatment. It is used as sequestrant, emulsifier, mordant in dyeing, reagent and buffer in foods and analytical chemistry. It is applied as a fireproofing agent and for weighting silk in tanning. It is employed in manufacturing of enamels, ceramics, detergents, boiler compounds, in soldering and brazing instead of borax.Monobasic sodium phosphate is used in baking powders, acid cleansers, electroplating, as a dry acidulant, and in treating boiler water.
Anhydrous salt: white crystalline powder; slightly hygroscopic; forms sodium acid pyrophosphate, Na2H2P2O7 on heating above 225°C and sodium metaphosphate (NaPO3)n at about 350 to 400°C; very soluble in water, aqueous solution acidic.Monohydrate: white orthorhombic crystals or granules; density 2.04 g/cm3 ; loses its water of crystallization at 100°C; very soluble in water, pH of 1% solution 4.5; insoluble in alcohol.Dihydrate: large transparent crystals; orthorhombic bisphenoidal structure; density 1.915 g/cm 3 ; decomposes at 60°C; very soluble in water; insoluble in alcohol.
The USP 32 states that monobasic sodium phosphate contains one or two molecules of water of hydration or is anhydrous.The hydrated forms of monobasic sodium phosphate occur as odorless, colorless or white, slightly deliquescent crystals. The anhydrous form occurs as a white crystalline powder or granules.
Useful in conjuction with sodium phosphate, dibasic (Cat. No. 567550) in the preparation of biological buffers(absorbance: ≤0.01 at 260 nm and 280 nm).
Sodium Phosphate Monobasic Monohydrate Basic Attributes
137.992291
137.969406
600-102-0
593YOG76RN
Yes
DTXSID6073994
White semi-transparentor
2835 22 00
Characteristics
λ: 260 nm Amax: ≤0.03λ: 280 nm Amax: ≤0.02
81.6
-0.55470
White semi-transparentor Solid
2,04 g/cm3
100°C -H₂O
399 °C
Soluble in water; insoluble in ethanol, ether and chloroform.
+15C to +30C
LD50 orally in Rabbit: > 2000 mg/kg LD50 dermal Rabbit > 7940 mg/kg
Odorless
4.1-4.5 (25℃, 50mg/mL in H2O)
7.21
Store at +5°C to +30°C.
Safety Information
NONH for all modes of transport
1
Xi
26-36/37/39-36-39-24/25
WA1900000
Xi
Monobasic sodium phosphate is chemically stable, although it is slightly deliquescent. On heating at 100°C, the dihydrate loses all of its water of crystallization. On further heating, it melts with decomposition at 205℃, forming sodium hydrogen pyrophosphate, Na2H2P2O7. At 250℃ it leaves a final residue of sodium metaphosphate, NaPO3.Aqueous solutions are stable and may be sterilized by autoclaving.Monobasic sodium phosphate should be stored in an airtight container in a cool, dry place.
P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P312, P304+P340, P305+P351+P338, P312, P321, P322, P330, P332+P313, P337+P313, P362, P363, P403+P233, P405, P501
36/37/38-36
Monobasic sodium phosphate is an acid salt and is therefore generally incompatible with alkaline materials and carbonates; aqueous solutions of monobasic sodium phosphate are acidic and will cause carbonates to effervesce.Monobasic sodium phosphate should not be administered concomitantly with aluminum, calcium, or magnesium salts since they bind phosphate and could impair its absorption from the gastrointestinal tract. Interaction between calcium and phosphate, leading to the formation of insoluble calcium phosphate precipitates, is possible in parenteral admixtures.
|Warning|H315 (90%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 46 companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Sodium Phosphate Monobasic Monohydrate Use and Manufacturing
Excipient.
Sodium Phosphate Monobasic Monohydrate is often used in foods and in water treatment. it can be used as a buffer to adjust pH. In medicine, it is sometimes used as a stimulant laxative before certain operations and medical procedures.
Sodium phosphate monobasic monohydrate has been used for the preparation of cardioplegia solution. It has also been used as a component in McIlvaine′s buffer and MgCl2buffer.
Monobasic sodium phosphate is prepared by adding phosphoric acid to a hot, concentrated solution of disodium phosphate until the liquid ceases to form a precipitate with barium chloride. This solution is then concentrated and the monobasic sodium phosphate is crystallized.
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