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CEPHALEXIN MONOHYDRATE

CEPHALEXIN MONOHYDRATE structure

CAS No:
23325-78-2
Formula:
C16H19N3O5S
Chemical Name:
CEPHALEXIN MONOHYDRATE
Synonyms:
CEPHALEXIN HYDRATE;CEPHALEXIN MONOHYDRATE;CEFALEXIN HYDRATE;5-Thia-1-azabicyclo4.2.0oct-2-ene-2-carboxylic acid, 7-(2R)-aminophenylacetylamino-3-methyl-8-oxo-, monohydrate, (6R,7R)-;cefalexin monohydrat;CEPHALEXIN MONOHYDRATE BP USP GRADE;CEFALEXIN MONOHYDRATE;KEFLEX
Categories:
Active Pharmaceutical Ingredients > Antibiotics

Description

Cefalexin monohydrate is a cephalosporin antibiotic.Target: AntibacterialCefalexin (INN, BAN) or cephalexin (USAN, AAN) is a first-generation cephalosporin antibiotic introduced in 1967 by Eli Lilly and Company. It is an orally administered agent with a similar antimicrobial spectrum to the intravenous agents cefalotin and cefazolin. It was first marketed as Keflex (Lilly), and is marketed under several other trade names. As of 2008, cefalexin was the most popular cephalosporin antibioti

Cephalexin was first synthesized in 1967 by Glaxo Research Laboratories and first produced on an industrial scale by Eli Lilly & Co. in the same year. It is a deacetoxylated derivative of cephaloglycin that is not metabolized in vivo. When administered orally, it shows a much higher serum concentration and much lower tendency to induce diarrhea than cephaloglycin. Cephalexin has been used widely and is the most popular orally active antibiotic in the world for treatment of respiratory tract, urinary tract, surgical, ear and nose, and other infections caused by Staphylococcus, Streptococcus, Escherichia coli, Klebsiella, Enterobacter, and Proteus.

White to Off-White Solid

ChEBI: The hydrate of cephalexin.

CEPHALEXIN MONOHYDRATE Basic Attributes

Molecular Weight：

365.4

Exact Mass：

383.070648

BRN：

965503

EC Number：

629-748-1

Color/Form：

White to Light Beige

HScode：

29419052

Characteristics

PSA：

139

XLogP3：

0.65 (LogP)

Density：

1.5g/cm3

Melting Point：

>161°C (dec.)

Boiling Point：

727.4°C at 760 mmHg

Flash Point：

393.7ºC

Refractive Index：

154 ° (C=0.5, H2O)

Water Solubility：

13.5g/L(25 ºC)

Storage Conditions：

2-8°C

Toxicity：

LD50 in mice, rats (g/kg): 1.6-4.5, >5.0 orally; 0.4-1.3, >3.7 i.p. (Welles)

Critical Temperature & Pressure：

Keep in dark place,Sealed in dry,Room Temperature

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

safety instructions：

22-36/37-45-24/25

RTECS Number：

XI0350000

Marks：

Stability/Shelf Life：

ACID-STABLE

Precautionary statement(s)：

P261, P264, P270, P272, P280, P285, P301+P312, P302+P352, P304+P341, P321, P330, P333+P313, P342+P311, P363, P501

Hazard Statements：

42/43

CEPHALEXIN MONOHYDRATE Use and Manufacturing

A semisynthetic cephalorsporin antibiotic.

Cephalosporin antibacterial.

Semi-synthetic cephalosporin antibiotic.

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23325-78-2 (6R,7R)-7-[[(2R)-2-amino-2-phenylacetyl]amino]-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;hydrate

CAS No.: 23325-78-2

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