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Terbinafine hydrochloride

Terbinafine hydrochloride structure

CAS No:
78628-80-5
Formula:
C21H25N.ClH
Chemical Name:
Terbinafine hydrochloride
Synonyms:
1-Naphthalenemethanamine,N-[(2E)-6,6-dimethyl-2-hepten-4-yn-1-yl]-N-methyl-,hydrochloride (1:1);1-Naphthalenemethanamine,N-(6,6-dimethyl-2-hepten-4-ynyl)-N-methyl-,hydrochloride,(E)-;1-Naphthalenemethanamine,N-[(2E)-6,6-dimethyl-2-hepten-4-ynyl]-N-methyl-,hydrochloride;Terbinafine hydrochloride;Terbina;Lamisil;Bramazil;Bramizil;Muzonal;Terbine;Lamisil Once
Categories:
Organic Chemistry > Hydrocarbons and Derivatives

Description

Terbinafine hydrochloride (TDT 067 hydrochloride) is an antifungal medication used to treat fungal infections. It is a potent non-competitive inhibitor of squalene epoxidase from Candida with a Ki of 30 nM.

Terbinafine hydrochloride Basic Attributes

Molecular Weight：

327.89100

Exact Mass：

327.17500

EC Number：

616-640-4

HScode：

2921499090

Characteristics

PSA：

3.24000

XLogP3：

5.67930

Appearance：

Crystalline powder

Density：

1.007g/cm3

Melting Point：

205 °C @ Solvent: Isopropanol

Boiling Point：

417.9ºC at 760 mmHg

Flash Point：

183.7ºC

Refractive Index：

1.586

Storage Conditions：

-20ºC Freezer

Toxicity：

LD50 in mice, rats (mg/kg): 4000, 4000 orally; 393, 213 i.v. (Ganzinger)

Safety Information

Transport codes：

UN 3077 9/PG 3

wgk germany：

hazard class code：

R36/37/38

safety instructions：

S26; S36/37/39; S61; S60

RTECS Number：

QJ8600100

Marks：

Xi; N

Precautionary statement(s)：

P305 + P351 + P338

Hazard Statements：

H315-H319-H335-H410

Terbinafine hydrochloride Use and Manufacturing

1. An orally active, antimycotic allylamine related to Naftifine. A specfic inhibitor of squalene epoxidase, a key enzyme in fungal ergosterol biosynthesis. Antifungal.
2. Terbinafine hydrochloride is a synthetic allylamine antifungal. It is used to treat dermatophyte infections of the toenail/fingernail, ringworm and jock itch. It is used in adsorption, partition and stability studies.

Drug Function and Efficacy

This product is a broad-spectrum antifungal drug that can highly selectively inhibit fungal squalene epoxidase, block the squalene epoxidation reaction in the process of fungal cell membrane formation and interfere with the early biosynthesis of fungal sterols, thereby playing a role in inhibiting and killing fungi.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Terbinafine Hydrochloride Cream
Ingredients	Each vial of this product contains the main ingredient 0.1 gram of terbinafine hydrochloride, and the excipients are: white vaseline, propylene glycol, Tween-80, glyceryl monostearate, and stearic acid.
Indication	Drug interactions may occur if used with other drugs. Please consult your doctor or pharmacist for details.
Specifications	10g:0.1g
Manufacturer	Qilu Pharmaceutical Co., Ltd.

Terbinafine Hydrochloride Cream
Ingredients	Each gram of this product contains 0.01 gram of the main ingredient, terbinafine hydrochloride. Excipients are: isopropyl myristate, Tween 60, stearyl alcohol, hexadecanol, hexadecyl palmitate, Span 60, benzyl alcohol. Chemical name: (E)-N-(6,6-dimethyl-2-heptene-4-ynyl)-N-methyl-1-naphthylmethylamine hydrochloride Molecular weight: C21H25N.HCl
Indication	Drug interactions may occur if used with other drugs. Please consult your doctor or pharmacist for details.
Specifications	1%

Terbinafine hydrochloride spray
Ingredients	The main ingredient of this product is terbinafine hydrochloride.
Indication	Drug interactions may occur if used with other drugs. Please consult your doctor or pharmacist for details.
Specifications	0.01

See More Related Drugs

Registered Holders

CHROMO LABORATORIES INDIA PRIVATE LTD

United States
Active
ALIVUS LIFE SCIENCES LTD

United States
Active
HETERO LABS LTD

United States
Active

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Guide of Terbinafine hydrochloride

Description
Basic Attributes
Characteristics
Safety Information
Use and Manufacturing
Drug Function and Efficacy
Related Drugs
Registered Holders
Recommended Suppliers
Latest News
Learn More Other Chemicals

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