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Ozenoxacin

Ozenoxacin structure

CAS No:
245765-41-7
Formula:
C21H21N3O3
Chemical Name:
Ozenoxacin
Synonyms:
Ozenoxacin;T 3912;:3-Quinolinecarboxylic acid, 1-cyclopropyl-1,4-dihydro-8-methyl-7-[5-methyl-6-(methylamino)-3-pyridinyl]-4-oxo-;Ozenoxacin(T 3912);1-cyclopropyl-8-methyl-7-[5-methyl-6-(methylamino)pyridin-3-yl]-4-oxoquinoline-3-carboxylic acid;Ozenoxacin , T 3912,UNII-V0LH498RFO;Ozenoxacin Impurity 1;organic materials Ozenoxacin
Categories:
Organic Chemistry > Amides

Description

Ozenoxacin is used to treat impetigo (a skin infection caused by bacteria) in adults and children 2 months of age and older. Ozenoxacin is in a class of medications called antibacterials. It works by killing and stopping the growth of bacteria on the skin. To date, ozenoxacin has been used in trials studying the treatment of impetigo. As of December 11, 2017 the FDA approved Ferrer Internacional S.A.'s Xepi (ozenoxacin 1%) as a topically applied cream indicated for the treatment of impetigo caused by Staphylococccus aureus or Streptococcus pyogenes in adult and pediatric patients 2 months of age and older.

Ozenoxacin is a novel, nonfluorinated quinolone antibiotic discovered by Toyama Chemical Co. Ltd. and developed by Maruho Co. Ltd. Ozenoxacin was approved by the PMDA of Japan in September 2015 for the treatment of acne and skin infections. Ozenoxacin shows potent antibacterial activity against anaerobic and aerobic, gram-positive and -negative bacteria, especially those implicated in superficial skin infections such as S. aureus, Staphylococcus epidermidis, and Propionibacterium acnes. The mechanism of action of ozenoxacin involves the drug’s affinity for DNA gyrase and DNA topoisomerase IV and upon binding triggers bacterial apoptosis.

ChEBI: Ozenoxacin is a member of quinolines.

Ozenoxacin Basic Attributes

Molecular Weight：

363.41

Exact Mass：

363.41

EC Number：

105-745-2

Color/Form：

Off-White

Characteristics

Density：

1.372±0.06 g/cm3(Predicted)

Melting Point：

>255°C (dec.)

Boiling Point：

573.5±50.0 °C(Predicted)

PKA：

6.46±0.50(Predicted)

Critical Temperature & Pressure：

2-8°C(protect from light)

Safety Information

wgk germany：

WGK 3

Ozenoxacin Use and Manufacturing

Ozenoxacin is a non-fluorinated topical quinolone. It exhibits antimicrobial activity againstpropionibacteria and staphylococci. Ozenoxacin can be used to treat acne and superficial skin infections.

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