 Home > Encyclopedia > Elagolix Sodium

Elagolix Sodium

Elagolix Sodium structure

CAS No:
832720-36-2
Formula:
C32H29F5N3NaO5
Chemical Name:
Elagolix Sodium
Synonyms:
Elagolix sodiuM;NBI 56418NA(elagolix na);4-{2-[5-(2-fluoro-3-methoxy-phenyl)-3-(2-fluoro-6-trifluoromethyl-benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl]-1-phenyl-ethylamino}-butyrate;elagolix sodium salt;Elagolix sodiu;Elagollix;sodium,4-[[(1R)-2-[5-(2-fluoro-3-methoxyphenyl)-3-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-4-methyl-2,6-dioxopyrimidin-1-yl]-1-phenylethyl]amino]butanoate;NBI-56418 sodium
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

Description

Elagolix sodium (ABT-620) is a small molecule, orally active gonadotropin-releasing hormone (GnRH) receptor antagonist. It has the ability to suppress estradiol (E2) concentrations in a dose-dependent manner.It was originally developed by Neurocrine Biosciences, then licensed to Abbott (now Abbvie) for worldwide co-development of this indication in 2010. AbbVie is applying to use elagolix for the treatment of endometriosis with associated pain. Elagolix is the first orally available GnRH antagonist, and as such may provide patients with relief from the painful symptoms of endometriosis while offering advantages over currently available injectable peptide-based treatments. The estimated patient population is over 170 million women worldwide.

Elagolix is an antagonist of the gonadotropin-releasing hormone receptor (GnRHR; Ki= 0.9 nM in a radioligand binding assay). It is selective for GnRHR over the cytochrome P450 (CYP) isoform CYP3A4 (IC50= 56 μM) as well as a panel of 100 receptors, ion channels, enzymes, and transporters (IC50s = >10 μM). Elagolix inhibits GnRH-induced inositol phosphate production in RBL-1 cells expressing human GnRHR (IC50= 1.5 nM).In vivo, elagolix (30 mg/kg) suppresses production of luteinizing hormone in castrated male cynomolgus macaques. Formulations containing elagolix have been used in the treatment of endometriosis.

Elagolix sodium is a small synthetic molecule chemically known as Sodium 4-({(1R)-2- [5-(2-fluoro-3-methoxyphenyl)-3-{[2-fluoro-6-(trifluoromethyl) phenyl]methyl}-4- methyl -2,6-dioxo-3,6-dihydropyrimidin-1(2H)-yl]-1-phenylethyl} amino)butanoate. The structure was confirmed by mass spectrometry, infrared spectroscopy, nuclear magnetic resonance.Elagolix sodium is isolated as a hygroscopic, amorphous white to off-white to light yellow powder.

Elagolix Sodium Basic Attributes

Molecular Weight：

653.571546

Color/Form：

White to Off-White

Characteristics

Melting Point：

>188°C (dec.)

Water Solubility：

H2O: 2mg/mL, clear

Critical Temperature & Pressure：

Hygroscopic, -20°C Freezer, Under inert atmosphere

Safety Information

wgk germany：

WGK 3

Elagolix Sodium Use and Manufacturing

Elagolix Sodium is a gonadotropin releasing hormone antagonist (GnRH antagonist) used in the treatment of pain associated with endometriosis in women. It is also in phase III clinical trials for the treatment of uterine fibroids in women. Endometriosis is a frequent cause of infertility, connected with a chronic pelvic and pre-menstrual pain.Elagolix sodium for the treatment of women with moderate to severe endometriosis-associated pain

Elagolix Sodium is a novel uracil phenylethylamine that acts as potent human gonadotropin-releasing hormone receptor (hGnRH-R) antagonist.

Recommended Suppliers of Elagolix Sodium

HONGKONG IPURE CHEMICAL CO., LIMITED Contact Supplier

HK
1 YR

Business licensed

Trader Supplier of pharmaceutical intermediates,chemical

Elagolix sodium 832720-36-2 in stocks

CAS No.: 832720-36-2

Grade: Pharmaceutical Grade

Content: 99%

Inquiry
Wuhan Pnq Int Trade Co., Ltd Contact Supplier

CN
3 YRS

Business licensed

Trader Supplier of Apigenin,PQQ,NMNH

Elagolix Sodium CAS 832720-36-2

Unit Price: $10.3-11.33 /G FOB

CAS No.: 832720-36-2

Grade: Chemical Grade

Content: 99%

Inquiry
Honour Enterprise Company Limited Contact Supplier

CN
4 YRS

Business licensed

Trader Supplier of Semaglutide,Tirzepatide,API,Enzyme

More than 15 years GMP Factory Suppy 99.5% Elagolix sodium Medical Grade CAS832720-36-2

CAS No.: 832720-36-2

Grade: Pharmaceutical Grade

Content: 99.5%

Inquiry
Shandong Airuike Chemical Co., Ltd. Contact Supplier

CN
3 YRS

Business licensed

Trader Supplier of api,Intermediates,Organic Chemistry,Inorganic Chemistry,Daily Chemicals,Cosmetic Raw Materals,CATALYST AND AUXILIARY,FLAVORS AND FRAGRANCES,Chemical Pesticides,ADDITIVE

ElagolixSodium

CAS No.: 832720-36-2

Grade: Analytical Reagent

Content: 99%

Inquiry
Chiyan Contact Supplier

CN
3 YRS

Business licensed

Trader Supplier of Upadacitinib Hemihydrate,(S)-(+)-1-Boc-3-hydroxypyrrolidine

Elagolix sodium

CAS No.: 832720-36-2

Inquiry