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Zolazepam

Zolazepam structure

CAS No:
31352-82-6
Formula:
C15H15FN4O
Chemical Name:
Zolazepam
Synonyms:
Pyrazolo[3,4-e][1,4]diazepin-7(1H)-one,4-(2-fluorophenyl)-6,8-dihydro-1,3,8-trimethyl-;Pyrazolo[3,4-e][1,4]diazepin-7(1H)-one,4-(o-fluorophenyl)-6,8-dihydro-1,3,8-trimethyl-;4-(2-Fluorophenyl)-6,8-dihydro-1,3,8-trimethylpyrazolo[3,4-e][1,4]diazepin-7(1H)-one;CI 716;Zolazepam;4-(o-Fluorophenyl)-6,8-dihydro-1,3,8-trimethylpyrazolo[3,4-e][1,4]diazepin-7(1H)-one;Flupyrazapon
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

Description

Zolazepam is a pyrazolodiazepinone derivative used as an anaesthetic in veterinary medicine. Zolazepam is typically used in combination with the NMDA antagonist tiletamine or the α2 adrenoceptor agonist xylazine. It is around four times the potency of diazepam but it is both water-soluble and un-ionized at physiological pH meaning that its onset is very fast.|A pyrazolodiazepinone with pharmacological actions similar to ANTI-ANXIETY AGENTS. It is commonly used in combination with TILETAMINE to obtain immobilization and anesthesia in animals.

Zolazepam Basic Attributes

Molecular Weight：

286.3

Exact Mass：

286.30

EC Number：

608-606-2

UNII：

G1R474U58U

DSSTox ID：

DTXSID30185278

Characteristics

PSA：

50.5 Å²

Density：

1.31±0.1 g/cm3

Melting Point：

183-185 °C @ Solvent: Methanol, Diethyl ether

Boiling Point：

506.6±50.0 °C(Predicted)

PKA：

1.85±0.20

Collision Cross Section：

162.3 Å² [M+H]+ [CCS Type: TW, Method: Major Mix IMS/Tof Calibration Kit (Waters)]

Safety Information

GHS Classification：

|Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.

Drug Information

MeSH：

Substances that do not act as agonists or antagonists but do affect the GAMMA-AMINOBUTYRIC ACID receptor-ionophore complex. GABA-A receptors (RECEPTORS, GABA-A) appear to have at least three allosteric sites at which modulators act: a site at which BENZODIAZEPINES act by increasing the opening frequency of GAMMA-AMINOBUTYRIC ACID-activated chloride channels; a site at which BARBITURATES act to prolong the duration of channel opening; and a site at which some steroids may act. GENERAL ANESTHETICS probably act at least partly by potentiating GABAergic responses, but they are not included here. (See all compounds classified as GABA Modulators.)|Agents that alleviate ANXIETY, tension, and ANXIETY DISORDERS, promote sedation, and have a calming effect without affecting clarity of consciousness or neurologic conditions. ADRENERGIC BETA-ANTAGONISTS are commonly used in the symptomatic treatment of anxiety but are not included here. (See all compounds classified as Anti-Anxiety Agents.)

MeSH Entry Terms：

CI 716

Zolazepam Use and Manufacturing

Uses

A sedative and anesthetic

Use Classification：

Pharmaceuticals -> Animal Drugs -> Approved in Taiwan

Computed Properties

Molecular Weight:286.30
XLogP3:1.7
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:286.12298928
Monoisotopic Mass:286.12298928
Topological Polar Surface Area:50.5
Heavy Atom Count:21
Complexity:455
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Recommended Suppliers of Zolazepam

Shaanxi Dideu Medichem Co. Ltd Contact Supplier

CN
5 YRS

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4-(o-Fluorophenyl)-6,8-dihydro-1,3,8-triMethylpyrazolo[3,4-e][1,4]diazepin-7(1H)- one-d3

CAS No.: 31352-82-6

Grade: Industrial Grade

Content: 99.5%

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