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Zolazepam hydrochloride

Zolazepam hydrochloride structure

CAS No:
33754-49-3
Formula:
C15H15FN4O.ClH
Chemical Name:
Zolazepam hydrochloride
Synonyms:
Pyrazolo[3,4-e][1,4]diazepin-7(1H)-one,4-(2-fluorophenyl)-6,8-dihydro-1,3,8-trimethyl-,hydrochloride (1:1);Pyrazolo[3,4-e][1,4]diazepin-7(1H)-one,4-(2-fluorophenyl)-6,8-dihydro-1,3,8-trimethyl-,monohydrochloride;Zolazepam hydrochloride
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

Description

A pyrazolodiazepinone with pharmacological actions similar to ANTI-ANXIETY AGENTS. It is commonly used in combination with TILETAMINE to obtain immobilization and anesthesia in animals.

Zolazepam hydrochloride Basic Attributes

Molecular Weight：

322.7651432

Exact Mass：

322.0996670 g/mol

EC Number：

251-668-7

UNII：

45SJ093Q1N

Characteristics

PSA：

50.49000

XLogP3：

1.98400

Melting Point：

248 °C (decomp)

Boiling Point：

506.6ºC at 760mmHg

Flash Point：

260.2ºC

Safety Information

Packing level：

III

Hazard category：

6.1(b)

Transport codes：

3249

GHS Classification：

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P312, P304+P340, P312, P322, P330, P363, and P501|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.

Drug Information

MeSH：

Substances that do not act as agonists or antagonists but do affect the GAMMA-AMINOBUTYRIC ACID receptor-ionophore complex. GABA-A receptors (RECEPTORS, GABA-A) appear to have at least three allosteric sites at which modulators act: a site at which BENZODIAZEPINES act by increasing the opening frequency of GAMMA-AMINOBUTYRIC ACID-activated chloride channels; a site at which BARBITURATES act to prolong the duration of channel opening; and a site at which some steroids may act. GENERAL ANESTHETICS probably act at least partly by potentiating GABAergic responses, but they are not included here. (See all compounds classified as GABA Modulators.)|Agents that alleviate ANXIETY, tension, and ANXIETY DISORDERS, promote sedation, and have a calming effect without affecting clarity of consciousness or neurologic conditions. ADRENERGIC BETA-ANTAGONISTS are commonly used in the symptomatic treatment of anxiety but are not included here. (See all compounds classified as Anti-Anxiety Agents.)

MeSH Entry Terms：

CI 716

Zolazepam hydrochloride Use and Manufacturing

Sedative-hypnotic.

Computed Properties

Molecular Weight:322.76
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:322.0996670
Monoisotopic Mass:322.0996670
Topological Polar Surface Area:50.5
Heavy Atom Count:22
Complexity:455
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes