MTS
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MTS
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CAS No:
35846-53-8
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Formula:
C34H46ClN3O10
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Chemical Name:
MTS
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Synonyms:
Maytansine;4,24-Dioxa-9,22-diazatetracyclo[19.3.1.110,14.03,5]hexacosane,maytansine deriv.;L-Alanine,N-acetyl-N-methyl-,11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.110,14.03,5]hexacosa-10,12,14(26),16,18-pentaen-6-yl ester,[1S-(1R*,2S*,3R*,5R*,6R*,16E,18E,20S*,21R*)]-;NSC 153858;Maytansin;N-Acetyl-N-methyl-L-alanine [1S-(1R*,2S*,3R*,5R*,6R*,16E,18E,20S*,21R*)]-11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.110,14.03,5]hexacosa-10,12,14(26),16,18-pentaen-6-yl ester;Maitansine;Maysanine;MTS
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CAS No:
Characteristics
157 Ų
1.1049
171-172 °C
895.1±65.0 °C(Predicted)
1.6000 (estimate)
LD50 in rats (mg/kg): 0.48 s.c. (Mugera, Ward)
9.82±0.70
Drug Information
Agents that interact with TUBULIN to inhibit or promote polymerization of MICROTUBULES. (See all compounds classified as Tubulin Modulators.)|Agents obtained from higher plants that have demonstrable cytostatic or antineoplastic activity. (See all compounds classified as Antineoplastic Agents, Phytogenic.)
DM1, Maytansinoid
Computed Properties
Molecular Weight:692.2
XLogP3:2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:10
Rotatable Bond Count:6
Exact Mass:691.2871724
Monoisotopic Mass:691.2871724
Topological Polar Surface Area:157
Heavy Atom Count:48
Complexity:1300
Undefined Atom Stereocenter Count:8
Undefined Bond Stereocenter Count:2
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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