High purity Maytansine CAS NO.35846-53-8
35846-53-8
Pharmaceutical Grade
99%
shanghai
Lonwin
1kg/bag,25kg/drum,25kg/bag
2024-02-02
CHEMICALS,REAGENTS
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Product Description
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Seller Information
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DescriptionECHEMI Editorial ReferenceAn ansa macrolide isolated from the MAYTENUS genus of East African shrubs.
This novel ansa macrolide alkaloid occurs in a number of May tan us species. The structure given has been elucidated from chemical and spectroscopic data. In low doses (25-50 mcg/kg), maytansine prolonged the survival of mice bearing vincristine-sensitive P388 leukemia but not those bearing vincristine-resistant tumour lines. In vitro, it suppressed the growth of U21 0, LSl78Y and P388 leukemia cells with ED50of 2 X 10-9, 1.5 X 10-9and 6 X 10-10M respectively and elevated the mitotic index in L 121 0 cells. From labelling studies it was shown that the alkaloid inhibited DNA formation by P388 cells to a greater extent than RNA and protein synthesis. Maytensine did not inhibit RNA polymerase from Escherichia coli at levels as high as 1 X 10-4M.
ChEBI: An organic heterotetracyclic compound and 19-membered macrocyclic lactam antibiotic originally isolated from the Ethiopian shrub Maytenus serrata but also found in other Maytenus species. It exhibits cytotoxicity against many tumo r cell lines.Basic Info-
Product Name:
Maytansine
Other Name:maitansine;Maytansine;NSC 153858;(14S,16S,32S,33S,2R,4S,10E,12E,14R)-86-Chloro-14-hydroxy-85,14-dimethoxy-33,2,7,10-tetramethyl-12,6-dioxo-7-aza-1(6,4)-oxazinana-3(2,3)-oxirana-8(1,3)-benzenacyclotetradecaphane-10,12-dien-4-yl N-acetyl-N-methyl-L-alaninate;Maitansina;Microtubule/Tubulin,tumor,mitotic,microtubule-targeted,arrest,Inhibitor,potent,subnanomolar,Maytansine,inhibit;(1S,2R,3S,5S,6R,16E,18E,20R,21S)-11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.11?,1?.03,?]hexacosa-10,12,14(26),16,18-pentaen-6-yl (2S)-2-(N-methylacetamido)propanoate;Maytansine, 10 mM in DMSO
CAS No.:35846-53-8
Molecular Formula:C34H46ClN3O10
InChIKeys:WKPWGQKGSOKKOO-YHBUUTGONA-N
Molecular Weight:692.2
Exact Mass:692.20
EC Number:252-754-7
Color/Form:white to beige
Categories:
Characteristics-
PSA:
157 Ų
Density:1.1049 (rough estimate)
Melting Point:183.5-184℃
Boiling Point:895.1±65.0 °C(Predicted)
Refractive Index:1.6000 (estimate)
Toxicity:LD50 in rats (mg/kg): 0.48 s.c. (Mugera, Ward)
PKA:9.82±0.70(Predicted)
Critical Temperature & Pressure:Store at -20°C
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Seller Information
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Business Type:
Trader
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Main Products:
CHEMICALS,REAGENTS
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Location:
No 966 Huaxu Road, Qingpu District, Shanghai, 201702, P.R. China
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Payment Terms:
TT against copy of documents,L/C,TT against B/L draft before shipment,100% TT in advance
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Average lead Time:
10
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Total Annual Revenue:
$10 million-$25 million
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Total Employees:
11-50
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Year of Establishment:
2011
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