HNE
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HNE
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CAS No:
75899-68-2
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Formula:
C9H16O2
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Chemical Name:
HNE
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Synonyms:
Ccris 1781;(E)-4-HYDROXYNONENAL;HNE;4-HYDROXY-2-NONENAL;4-HNE;(+/-)-4-HYDROXY-2E-NONENAL;(+/-)-4-HYDROXYNON-2-ENAL;4-HYDROXYNONENAL
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CAS No:
Description
Solid
4-hydroxynon-2-enal is an enal consisting of non-2-ene having an oxo group at the 1-position and a hydroxy group at the 4-position. It has a role as a human metabolite. It is a hydroxyaldehyde, an enal and a 4-hydroxynonenal.
Drug Information
Exogenous and endogenous compounds which inhibit CYSTEINE ENDOPEPTIDASES. (See all compounds classified as Cysteine Proteinase Inhibitors.)|Reagents with two reactive groups, usually at opposite ends of the molecule, that are capable of reacting with and thereby forming bridges between side chains of amino acids in proteins; the locations of naturally reactive areas within proteins can thereby be identified; may also be used for other macromolecules, like glycoproteins, nucleic acids, or other. (See all compounds classified as Cross-Linking Reagents.)
4-HNE cpd
HNE Use and Manufacturing
HNE is a lipid peroxidation product derived from oxidized ω-6 polyunsaturated fatty acids such as arachidonic acid. 4-hydroxy Nonenal is widely used as a marker of lipid peroxidation. It exhibits various biological activities such as cytotoxicity, growth inhibiting activity, genotoxicity, and chemotactic activity. HNE inhibits pro-oxidant-induced Ca 2+ release from mitochondria at 10-50 μM.[Cayman Chemical]
4-Hydroxynonenal is an irreversible inhibitor of Na+/K+-ATPase activity.
Fatty Acyls [FA] -> Fatty aldehydes [FA06]
Computed Properties
Molecular Weight:156.22
XLogP3:1.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:6
Exact Mass:156.115029749
Monoisotopic Mass:156.115029749
Topological Polar Surface Area:37.3
Heavy Atom Count:11
Complexity:119
Undefined Atom Stereocenter Count:1
Defined Bond Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
