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Biolimus A9

Biolimus A9 structure

CAS No:
851536-75-9
Formula:
C55H87NO14
Chemical Name:
Biolimus A9
Synonyms:
Rapamycin,42-O-(2-ethoxyethyl)-;42-O-(2-Ethoxyethyl)rapamycin;Biolimus A9;40-O-(2-Ethoxyethyl)rapamycin;Ba 9;TRM 986;Umirolimus;Biolimus;944472-64-4
Categories:
Organic Chemistry > Lactones

Request for Quotation

Biolimus A9 Basic Attributes

Molecular Weight：

986.28

Exact Mass：

986.28

UNII：

U36PGF65JH

Characteristics

PSA：

193.66000

XLogP3：

7.17930

Density：

1.15±0.1 g/cm3

Boiling Point：

991.0±75.0 °C(Predicted)

PKA：

10.40±0.70

Drug Information

MeSH：

Substances that reduce or suppress INFLAMMATION. (See all compounds classified as Anti-Inflammatory Agents.)|Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging. (See all compounds classified as Immunosuppressive Agents.)

MeSH Entry Terms：

40-O-(2-ethoxyethyl)rapamycin

Biolimus A9 Use and Manufacturing

Umirolimus is a semi-synthetic macrocyclic lactone prepared from rapamycin by selective alkylation of the 42-hydroxy group, providing one of most hydrophobic tacrolimus analogues. Umirolimus has been targeted for use in stents and medical devices to suppress localised immunoreaction. Like all tacrolimus analogues, umirolimus binds to receptor protein, FKBP12. The complex then binds to mTOR and prevents it from interacting with target proteins. Umirolimus is extensively cited in the literature with over 70 citations.

Computed Properties

Molecular Weight:986.3
XLogP3:6.8
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:14
Rotatable Bond Count:11
Exact Mass:985.61265645
Monoisotopic Mass:985.61265645
Topological Polar Surface Area:194
Heavy Atom Count:70
Complexity:1840
Defined Atom Stereocenter Count:15
Defined Bond Stereocenter Count:4
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes