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Lipoxin B4

Lipoxin B4 structure

Lipoxin B4 

structure
  • CAS No:

    98049-69-5

  • Formula:

    C20H32O5

  • Chemical Name:

    Lipoxin B4

  • Synonyms:

    6,8,10,12-Eicosatetraenoic acid,5,14,15-trihydroxy-,(5S,6E,8Z,10E,12E,14R,15S)-;6,8,10,12-Eicosatetraenoic acid,5,14,15-trihydroxy-,[5S-(5R*,6E,8Z,10E,12E,14S*,15R*)]-;(5S,6E,8Z,10E,12E,14R,15S)-5,14,15-Trihydroxy-6,8,10,12-eicosatetraenoic acid;Lipoxin B4;LXB4;5S,14R,15S-Trihydroxy-6,10,12-trans-8-cis-eicosatetraenoic acid

Lipoxin B4 Basic Attributes

352.47

352.47

Safety Information

11-36/37/38

16-26-36

F,Xi

Lipoxin B4 Use and Manufacturing

Lipoxins are a series of anti-inflammatory lipid mediators whose brief appearance generally signals the resolution of inflammation. Lipoxin A4 (LXA4) is a potent inhibitor of leukotriene (LT)-triggered polymorphonuclear neutrophil (PMN)-endothelial cell interaction and also blocks PMN migration stimulated by LTB4. LXB4 is a positional isomer of LXA4 produced by the metabolism of 15-HETE or 15-HpETE by human leukocytes. At a concentration of 10-7 M, LXB4 inhibits PMN migration stimulated by LTB4 and inhibits LTB4-induced adhesion of PMNs with an IC50 value of ~3 X 10-10 M.

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