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24-norursodeoxycholicacid

24-norursodeoxycholicacid structure

CAS No:
99697-24-2
Formula:
C23H38O4
Chemical Name:
24-norursodeoxycholicacid
Synonyms:
24-norursodeoxycholic acid;(3α,5β,7β)-3,7-Dihydroxy-24-norcholan-23-oic Acid;3α,7β-Dihydroxy-24-nor-5β-cholan-23-oic Acid;Norursodeoxycholic Acid;nor-UDCA
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

Description

norUrsodeoxycholic acid is under investigation in clinical trial NCT03872921 (Norursodeoxycholic Acid vs Placebo in PSC).

24-norursodeoxycholicacid Basic Attributes

Molecular Weight：

378.55

Exact Mass：

378.27700969 g/mol

UNII：

8A5G600D9V

Characteristics

PSA：

77.76000

XLogP3：

4.08780

Density：

1.142±0.06 g/cm3

Boiling Point：

536.7±25.0 °C(Predicted)

PKA：

4.71±0.10

Drug Information

Drug Indication：

Treatment of autoimmune sclerosing cholangitis, Treatment of primary sclerosing cholangitis

MeSH Entry Terms：

24-norursodeoxycholic acid

24-norursodeoxycholicacid Use and Manufacturing

Uses

Ursodeoxycholic Acid (U850000) derivative. 24-norUrsodeoxycholic acid is superior to Ursodeoxycholic acid in the treatment of sclerosing cholangitis in Mdr2 (Abcb4) knockout mice.

Use Classification：

Human drugs -> Rare disease (orphan)|Human Drugs -> EU pediatric investigation plans|Lipids -> Sterol Lipids [ST] -> Bile acids and derivatives [ST04] -> C23 bile acids, alcohols, and derivatives [ST0406]

Computed Properties

Molecular Weight:378.5
XLogP3:4.6
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:378.27700969
Monoisotopic Mass:378.27700969
Topological Polar Surface Area:77.8
Heavy Atom Count:27
Complexity:591
Defined Atom Stereocenter Count:10
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Recommended Suppliers of 24-norursodeoxycholicacid

HANGZHOU LEAP CHEM CO., LTD. Contact Supplier

CN
5 YRS

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24-Nor Ursodeoxycholic Acid

CAS No.: 99697-24-2

Content: 99.00%

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Shaanxi Cuikang Pharmaceutical Technolog Contact Supplier

CN
4 YRS

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Manufactory Supplier of Cosmetics raw materials,Pesticide intermediate,Photoelectric material,pharmaceutical intermediates,Raw materials for food and health products,Polymer materials,Fine Chemicals,Synthetic customization

(3α,5β,7β)-3,7-Dihydroxy-24-norcholan-23-oic Acid

CAS No.: 99697-24-2

Grade: Industrial Grade

Content: 98%

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Guide of 24-norursodeoxycholicacid

Description
Basic Attributes
Characteristics
Drug Information
Use and Manufacturing
Computed Properties
Recommended Suppliers
Latest News
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