K-252B
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K-252B
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CAS No:
99570-78-2
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Formula:
C26H19N3O5
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Chemical Name:
K-252B
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Synonyms:
PROTEIN KINASE INHIBITOR K-252B;K-252B;K-252B, NOCARDIOPSIS SP;K-252B, NOCARDIOPSIS SPECIES;K252B READY MADE;k-252b solution;Antibiotic K 252b;ANTIBIOTIC K 252B
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CAS No:
Characteristics
105.72000
3.89550
ready-to-use solution
1.78±0.1 g/cm3
769.8±60.0 °C(Predicted)
-20ºC
3.33±0.40
K-252B Use and Manufacturing
K252A is a staurosporine analogue isolated from a Nocardiopsis strain as a potent inhibitor of protein kinase C. K252A exhibits potent antitumour activity but shows no antimicrobial activity in vitro, or in vivo toxicity in rodents. While K252A is a potent inhibitor of Ca2+/calmodulin kinase II, it is also active against other kinases, notably myosin light chain kinase, cAMP-dependent protein kinase (PKA), protein kinase C (PKC) and cGMP-dependent protein kinase (PKG).
Computed Properties
Molecular Weight:453.4
XLogP3:2.4
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:1
Exact Mass:453.13247072
Monoisotopic Mass:453.13247072
Topological Polar Surface Area:106
Heavy Atom Count:34
Complexity:961
Undefined Atom Stereocenter Count:3
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes