(-)-Oligomycin C
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(-)-Oligomycin C
structure -
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CAS No:
11052-72-5
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Formula:
C45H74O10
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Chemical Name:
(-)-Oligomycin C
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Synonyms:
Spiro[2,26-dioxabicyclo[23.3.1]nonacosa-4,18,20-triene-27,2′-[2H]pyran]-3,9,13-trione,22-ethyl-3′,4′,5′,6′-tetrahydro-7,11,15-trihydroxy-6′-[(2R)-2-hydroxypropyl]-5′,6,8,10,12,14,16,28,29-nonamethyl-,(1R,2′R,4E,5′S,6S,6′S,7R,8S,10R,11S,12S,14S,15S,16R,18E,20E,22R,25S,28S,29R)-;Oligomycin C;Oligomycin A,12-deoxy-;Spiro[2,26-dioxabicyclo[23.3.1]nonacosane-27,2′-[2H]pyran],oligomycin A deriv.;(1R,2′R,4E,5′S,6S,6′S,7R,8S,10R,11S,12S,14S,15S,16R,18E,20E,22R,25S,28S,29R)-22-Ethyl-3′,4′,5′,6′-tetrahydro-7,11,15-trihydroxy-6′-[(2R)-2-hydroxypropyl]-5′,6,8,10,12,14,16,28,29-nonamethylspiro[2,26-dioxabicyclo[23.3.1]nonacosa-4,18,20-triene-27,2′-[2H]pyran]-3,9,13-trione;(-)-Oligomycin C
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CAS No:
Characteristics
160 Ų
1.091 g/cm3
876.2±65.0 °C(Predicted)
LD50 ipr-mus: 8300 mg/kg JACSAT 80,6092,1958
13.49±0.70
Safety Information
III
6.1(b)
2811
22
RK3335000
Xn
|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P301+P312, P330, and P501|Aggregated GHS information provided by 127 companies from 1 notifications to the ECHA C&L Inventory.
(-)-Oligomycin C Use and Manufacturing
Oligomycin C, a minor component of the oligomycin complex isolated from selected strains of Streptomyces, is an inhibitor of mitochondrial F1F0-ATPase. It makes cells more susceptible to cell death, and also leads to a switch in the death mode from apoptosis to necrosis.
Computed Properties
Molecular Weight:775.1
XLogP3:8
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:10
Rotatable Bond Count:3
Exact Mass:774.52819855
Monoisotopic Mass:774.52819855
Topological Polar Surface Area:160
Heavy Atom Count:55
Complexity:1340
Undefined Atom Stereocenter Count:18
Undefined Bond Stereocenter Count:3
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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