GW 1929
-
GW 1929
structure -
-
CAS No:
196808-24-9
-
Formula:
C30H29N3O4
-
Chemical Name:
GW 1929
-
Synonyms:
L-Tyrosine,N-(2-benzoylphenyl)-O-[2-(methyl-2-pyridinylamino)ethyl]-;N-(2-Benzoylphenyl)-O-[2-(methyl-2-pyridinylamino)ethyl]-L-tyrosine;GW 1929;(S)-2-((2-Benzoylphenyl)amino)-3-(4-(2-(methyl(pyridin-2-yl)amino)ethoxy)phenyl)propanoic acid
-
CAS No:
Characteristics
91.76000
5.00860
1.264±0.06 g/cm3
749.2±60.0 °C(Predicted)
406.9ºC
1.657
1.41E-23mmHg at 25°C
3.91±0.10
GW 1929 Use and Manufacturing
Peroxisome proliferator-activated receptor (PPAR) γ is a nuclear receptor that, when activated, regulates fatty acid storage and glucose metabolism. The best known class of PPARγ ligands are the thiazolidinediones, including troglitazone and rosiglitazone . GW 1929 is a non-thiazolidinedione activator of PPARγ that binds with a Ki value of 1.4 nM, with greater than 1,000-fold selectivity over other PPAR subtypes. It has anti-hyperglycemic and anti-hyperlipidemic activity when given orally in mouse and rat models of type 2 diabetes. Both in vitro and in vivo effects of GW 1929 on PPARγ greatly exceed those produced by troglitazone. In addition, GW 1929 has neuroprotective effects in global cerebral ischemic-reperfusion injury that are related to reduced inflammation and apoptotic DNA fragmentation.[Cayman Chemical]
Computed Properties
Molecular Weight:495.6
XLogP3:6.4
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:12
Exact Mass:495.21580641
Monoisotopic Mass:495.21580641
Topological Polar Surface Area:91.8
Heavy Atom Count:37
Complexity:705
Defined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes