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GW 6471

GW 6471 structure

CAS No:
880635-03-0
Formula:
C35H36F3N3O4
Chemical Name:
GW 6471
Synonyms:
N-((2S)-2-(((1Z)-1-METHYL-3-OXO-3-(4-(TRIFLUOROMETHYL)PHENYL)PROP-1-ENYL)AMINO)-3-(4-(2-(5-METHYL-2-PHENYL-1,3-OXAZOL-4-YL)ETHOXY)PHENYL)PROPYL)PROPANAMIDE;[(2S)-2-[[(1Z)-1-METHYL-3-OXO-3-[4-(TRIFLUOROMETHYL)PHENYL]-1-PROPENYL]AMINO]-3-[4-[2-(5-METHYL-2-PHENYL-4-OXAZOLYL)ETHOXY]PHENYL]PROPYL]-CARBAMIC ACID ETHYL ESTER;GW 6471;Propanamide, N-[(2S)-2-[[(1Z)-1-methyl-3-oxo-3-[4-(trifluoromethyl)phenyl]-1-propen-1-yl]amino]-3-[4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]phenyl]propyl]-;GW 6471 USP/EP/BP;(S,Z)-N-(3-(4-(2-(5-Methyl-2-phenyloxazol-4-yl)ethoxy)phenyl)-2-((4-oxo-4-(4-(trifluoromethyl)phenyl)but-2-en-2-yl)amino)propyl)propionamide;N-[(2S)-3-{4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]phenyl}-2-{[(2Z)-4-oxo-4-[4-(trifluoromethyl)phenyl]but-2-en-2-yl]amino}propyl]propanamide;GW 6471, PPAR alpha antagonist
Categories:
Chemical Reagents > Organic Reagents

Description

GW6471 prevents apoptosis and cell cycle arrest at G0/G1in renal cell carcinoma. It reduces enhanced fatty acid oxidation and oxidative phosphorylation associated with glycolysis inhibition.

GW 6471 Basic Attributes

Molecular Weight：

619.67

Exact Mass：

619.67

Color/Form：

off-white

Characteristics

PSA：

93.5 Å²

Density：

1.204±0.06 g/cm3(Predicted)

PKA：

15.90±0.46(Predicted)

Critical Temperature & Pressure：

2-8°C

Safety Information

wgk germany：

hazard class code：

safety instructions：

26-36

Storage features：

Store at +4°C

Hazard Statements：

36/37/38

GHS Classification：

|Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 38 companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH Entry Terms：

GW 6471

GW 6471 Use and Manufacturing

GW 6471 is a potent antagonist of PPARα with IC50 of 0.24 μM.

GW 6471 is a peroxisome proliferator-activated receptor α (PPARα) antagonist. GW 6471 has been shown to enhance the binding affinity of the PPARα ligand-binding domain to the co-repressor proteins SMRT and NCoR.

Computed Properties

Molecular Weight:619.7
XLogP3:7.9
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:9
Rotatable Bond Count:14
Exact Mass:619.26579112
Monoisotopic Mass:619.26579112
Topological Polar Surface Area:93.5
Heavy Atom Count:45
Complexity:954
Defined Atom Stereocenter Count:1
Defined Bond Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Recommended Suppliers of GW 6471

Jinan topfull chemical co.,ltd Contact Supplier

CN
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GW 6471 | CAS 880635-03-0 | 98% HPLC | Yellow to Off-White Powder | Selective PPARα Antagonist | For Metabolic & Oncology Research

CAS No.: 880635-03-0

Grade: Reagent Grade

Content: 98%

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