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Antalarmin

Antalarmin structure

CAS No:
157284-96-3
Formula:
C24H34N4
Chemical Name:
Antalarmin
Synonyms:
7H-Pyrrolo[2,3-d]pyrimidin-4-amine,N-butyl-N-ethyl-2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)-;N-Butyl-N-ethyl-2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine;Antalarmin
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

Description

Antalarmin is a pyrrolopyrimidine that is 7H-pyrrolo[2,3-d]pyrimidin-4-amine which is substituted by methyl groups at positions 2, 5, and 6, by a mesityl group at position 7, and in which the amino substituent at position 4 has been substituted by ethyl and butyl groups. It is an antagonist of corticotropin-releasing factor 1 (CRF-1) receptors (Ki = 1 nM). It has a role as a corticotropin-releasing factor receptor antagonist. It is a pyrrolopyrimidine and a tertiary amino compound.

Antalarmin Basic Attributes

Molecular Weight：

378.55

Exact Mass：

378.55

NSC Number：

715590

DSSTox ID：

DTXSID50166241

Characteristics

PSA：

34 Å²

Density：

1.05±0.1 g/cm3

Boiling Point：

437.2±45.0 °C(Predicted)

PKA：

7.10±0.30

Safety Information

wgk germany：

safety instructions：

22-24/25

Drug Information

MeSH Entry Terms：

antalarmin

Computed Properties

Molecular Weight:378.6
XLogP3:6.6
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:6
Exact Mass:378.27834710
Monoisotopic Mass:378.27834710
Topological Polar Surface Area:34
Heavy Atom Count:28
Complexity:485
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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Butyl-ethyl-[2,5,6-trimethyl-7-(2,4,6-trimethyl-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-amine

CAS No.: 157284-96-3

Grade: Industrial Grade

Content: 99.5%

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